{"id":"selinexol-and-dexamethasone","safety":{"commonSideEffects":[{"rate":null,"effect":"Thrombocytopenia"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Fatigue"},{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Anemia"},{"rate":null,"effect":"Infection"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Selinexol is a selective inhibitor of nuclear export (SINE) that blocks XPO1 (exportin-1), causing accumulation of tumor suppressors like p53 and IκB in the nucleus, leading to apoptosis in cancer cells. Dexamethasone, a corticosteroid, is co-administered to mitigate selinexol-induced inflammatory side effects and improve patient tolerance during treatment.","oneSentence":"Selinexol inhibits nuclear export of tumor suppressor proteins by blocking XPO1, while dexamethasone provides immunosuppressive and anti-inflammatory effects to enhance tolerability.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:33:59.022Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Multiple myeloma"},{"name":"Diffuse large B-cell lymphoma (DLBCL)"}]},"trialDetails":[{"nctId":"NCT05347381","phase":"PHASE3","title":"Selinexol Combined With Dexamethasone in the Treatment of CAEBV","status":"UNKNOWN","sponsor":"Beijing Friendship Hospital","startDate":"2022-05-01","conditions":"CAEBV","enrollment":6}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":13857,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Selinexol and Dexamethasone","genericName":"Selinexol and Dexamethasone","companyName":"Beijing Friendship Hospital","companyId":"beijing-friendship-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Selinexol inhibits nuclear export of tumor suppressor proteins by blocking XPO1, while dexamethasone provides immunosuppressive and anti-inflammatory effects to enhance tolerability. Used for Multiple myeloma, Diffuse large B-cell lymphoma (DLBCL).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}