{"id":"self-administered-nitrous-oxide","safety":{"commonSideEffects":[{"rate":null,"effect":"Dizziness or lightheadedness"},{"rate":null,"effect":"Dissociation or altered mental status"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Vitamin B12 depletion with chronic use"},{"rate":null,"effect":"Peripheral neuropathy with prolonged exposure"}]},"_chembl":{"chemblId":"CHEMBL1234579","moleculeType":"Small molecule","molecularWeight":"44.01"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Nitrous oxide (N2O) is an inhalational gas that produces anesthesia and analgesia through non-competitive antagonism of NMDA glutamate receptors. It also enhances inhibitory GABAergic neurotransmission and may modulate monoamine systems. When self-administered in controlled settings, it provides rapid onset analgesia and mild sedation with quick recovery upon discontinuation.","oneSentence":"Nitrous oxide acts as a dissociative anesthetic and analgesic by antagonizing N-methyl-D-aspartate (NMDA) receptors in the central nervous system.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:07:19.087Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute pain relief and anxiolysis in medical settings"},{"name":"Procedural sedation and analgesia"}]},"trialDetails":[{"nctId":"NCT07491874","phase":"NA","title":"Use of Nitrous Oxide for Pain and Anxiety Management During Cervical Cerclage Removal- A Multicenter Randomized Controlled Study","status":"NOT_YET_RECRUITING","sponsor":"Kaplan Medical Center","startDate":"2026-05-01","conditions":"Preterm Delivery, Cervical Cerclage, Cervical Insufficiency","enrollment":60},{"nctId":"NCT05883332","phase":"PHASE4","title":"A Pilot Study to Assess Effects of Self-Administered Nitrous Oxide (SANO) on Urodynamic Study (UDS) Parameters","status":"COMPLETED","sponsor":"Beth Israel Deaconess Medical Center","startDate":"2023-01-10","conditions":"Lower Urinary Tract Symptoms","enrollment":19},{"nctId":"NCT05895383","phase":"PHASE4","title":"Self-Adjusted Nitrous Oxide: A Feasibility Study in the Setting of Vasectomy","status":"RECRUITING","sponsor":"Beth Israel Deaconess Medical Center","startDate":"2023-05-24","conditions":"Procedural Pain, Pain Catastrophizing, Procedural Anxiety","enrollment":35},{"nctId":"NCT07387315","phase":"PHASE4","title":"A Randomized, Placebo-controlled Trial of Nitrous Oxide During In-office Bladder Botox Injections","status":"NOT_YET_RECRUITING","sponsor":"TriHealth Inc.","startDate":"2026-02","conditions":"Overactive Bladder, Neurogenic Bladder, Urge Incontinence","enrollment":96},{"nctId":"NCT07245628","phase":"EARLY_PHASE1","title":"A Trial of Self-Adjusted Nitrous Versus Placebo During Office Vasectomy","status":"RECRUITING","sponsor":"Alexandra J. 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Used for Acute pain relief and anxiolysis in medical settings, Procedural sedation and analgesia.","enrichmentLevel":3,"visitCount":2,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}