{"id":"selenium-sulfide","rwe":[],"_fda":{"id":"fd6fd5da-41c0-4d4a-b606-0ea91ae7b71b","set_id":"0187b034-44d7-4b84-af04-d018bc9750f3","openfda":{"unii":["Z69D9E381Q"],"route":["TOPICAL"],"rxcui":["204642"],"spl_id":["fd6fd5da-41c0-4d4a-b606-0ea91ae7b71b"],"brand_name":["Walgreens Dandruff Maximum Strength Anti-dandruff"],"spl_set_id":["0187b034-44d7-4b84-af04-d018bc9750f3"],"package_ndc":["0363-4139-01"],"product_ndc":["0363-4139"],"generic_name":["SELENIUM SULFIDE"],"product_type":["HUMAN OTC DRUG"],"substance_name":["SELENIUM SULFIDE"],"manufacturer_name":["Walgreen Company"],"application_number":["M032"],"is_original_packager":[true]},"purpose":["Purpose Anti-dandruff"],"version":"3","stop_use":["Stop use and ask a doctor if condition worsens or does not improve after regular use as directed."],"warnings":["Warnings For external use only When using this product avoid contact with the eyes. If contact occurs, rinse eyes thoroughly with water. Stop use and ask a doctor if condition worsens or does not improve after regular use as directed. Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center (1-800-222-1222) right away."],"questions":["Questions or Comments? 1-800-925-4733"],"when_using":["When using this product avoid contact with the eyes. If contact occurs, rinse eyes thoroughly with water."],"effective_time":"20241101","active_ingredient":["Active ingredient Selenium Sulfide 1%"],"inactive_ingredient":["Inactive ingredients water, ammonium lauryl sulfate, ammonium laureth sulfate, distearyl phthalic acid amide, cocamide MEA, fragrance, titanium dioxide, dimethicone, hydroxypropyl methylcellulose, citric acid, sodium lauroyl lactylate, aloe barbadensis leaf juice, sodium citrate, sodium chloride, phenoxyethanol, methylchloroisothiazolinone, methylisothiazolinone, blue 1, yellow 10, ext. violet 2."],"storage_and_handling":["Other information store at room temperature"],"indications_and_usage":["Use helps prevent recurrence of flaking and itching associated with dandruff."],"spl_unclassified_section":["Drug Facts","DISTRIBUTED BY: WALGREEN CO. 200 WILMOT RD., DEERFIELD, IL 60015"],"dosage_and_administration":["Directions shake well wet hair massage onto scalp rinse repeat if desired for best results use at least twice a week or as directed by a doctor for maximum dandruff control, use every time you shampoo."],"spl_product_data_elements":["Walgreens Dandruff Maximum Strength Anti-dandruff Selenium Sulfide Selenium Sulfide Selenium Sulfide Water Ammonium Lauryl Sulfate DISTEARYL PHTHALAMIC ACID COCO MONOETHANOLAMIDE Glycerin Titanium Dioxide Dimethicone HYPROMELLOSE, UNSPECIFIED CITRIC ACID MONOHYDRATE SODIUM LAUROYL LACTYLATE SODIUM CITRATE, UNSPECIFIED FORM Sodium Chloride Phenoxyethanol Methylchloroisothiazolinone Methylisothiazolinone FD&C BLUE NO. 1 D&C YELLOW NO. 10 EXT. D&C VIOLET NO. 2"],"keep_out_of_reach_of_children":["Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center (1-800-222-1222) right away."],"package_label_principal_display_panel":["PRINCIPAL DISPLAY PANEL - 325 mL Bottle Label Walgreens • WALGREENS • PHARMACIST RECOMMENDED † Compare to the active ingredient in Selsun Blue ® † † MAXIMUM STRENGTH Dandruff Shampoo SELENIUM SULFIDE 1% Moisturizing + Aloe For the relief of dandruff symptoms Helps control flakes & itching* For healthier-looking hair & scalp 11 FL OZ (325 mL) 05-4484 PRINCIPAL DISPLAY PANEL - 325 mL Bottle Label"]},"tags":[{"label":"selenium sulfide","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"D01AE13","category":"atc"},{"label":"Topical","category":"route"},{"label":"Liquid","category":"form"},{"label":"Off-Patent","category":"patent"},{"label":"Generic Available","category":"availability"},{"label":"Established","category":"status"},{"label":"Pityriasis simplex","category":"indication"},{"label":"Pityriasis versicolor","category":"indication"},{"label":"Seborrheic dermatitis","category":"indication"},{"label":"Chattem","category":"company"},{"label":"Approved 1950s","category":"decade"},{"label":"Dermatologic Agents","category":"pharmacology"}],"phase":"marketed","safety":{"boxedWarnings":[],"contraindications":["Distinctive exudative discoid AND lichenoid chronic dermatosis of Sulzberger and Garbe","Inflammatory dermatosis"],"specialPopulations":{"Pregnancy":"Under ordinary circumstances, selenium sulfide 2.25% shampoo should not be used by pregnant women.","Paediatric use":"Safety and effectiveness in children under the age of 12 years have not been established."}},"trials":[],"aliases":[],"company":"Chattem","patents":[],"pricing":[{"market":"United States","source":"CMS National Average Drug Acquisition Cost (NADAC)","asOfDate":"2024-01-03","unitCost":"$0.2977/ML","priceType":"NADAC","sourceUrl":"https://data.medicaid.gov/dataset/4j6z-xnwq","annualCost":"$107","description":"SELENIUM SULFIDE 2.25% SHAMPOO","retrievedDate":"2026-04-07"}],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=SELENIUM SULFIDE","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T03:46:27.302927+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T03:46:32.638074+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=SELENIUM SULFIDE","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T03:46:32.956550+00:00"},"administration.route":{"url":"","method":"deterministic","source":"FDA Label","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T03:46:26.195787+00:00"},"safety.boxedWarnings":{"url":"","method":"deterministic","source":"FDA Label (no boxed warning)","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T03:46:26.195804+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1200680/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T03:46:33.957602+00:00"},"regulatory.fda_application":{"url":"","method":"deterministic","source":"FDA Label","rawText":"M032","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T03:46:26.195807+00:00"}},"allNames":"selsun","offLabel":[],"synonyms":["selenium sulfide","selenium disulfide"],"timeline":[{"date":"1951-01-01","type":"neutral","source":"FDA Orange Book","milestone":"Rights transferred from CHATTEM to Chattem"},{"date":"1951-05-17","type":"positive","source":"DrugCentral","milestone":"FDA approval (Chattem)"}],"aiSummary":"Selsun is a small molecule drug in the selenium sulfide class, originally developed by Chattem and currently owned by the same company. It was FDA approved in 1951 for the treatment of Pityriasis simplex, Pityriasis versicolor, and Seborrheic dermatitis. Selsun is available as a generic medication, with six generic manufacturers, and is off-patent. As a topical treatment, it is applied directly to the affected skin area. Key safety considerations include potential skin irritation and allergic reactions.","approvals":[{"date":"1951-05-17","orphan":false,"company":"CHATTEM","regulator":"FDA"}],"brandName":"Selsun","ecosystem":[{"indication":"Pityriasis simplex","otherDrugs":[{"name":"allantoin","slug":"allantoin","company":""},{"name":"ammonia","slug":"ammonia","company":""},{"name":"carbamide","slug":"carbamide","company":"Hospira"},{"name":"chloroxine","slug":"chloroxine","company":""}],"globalPrevalence":null},{"indication":"Pityriasis versicolor","otherDrugs":[{"name":"acrisorcin","slug":"acrisorcin","company":"Schering"},{"name":"butenafine","slug":"butenafine","company":"Mylan"},{"name":"carbamide","slug":"carbamide","company":"Hospira"},{"name":"ciclopirox","slug":"ciclopirox","company":"Medimetriks Pharms"}],"globalPrevalence":null},{"indication":"Seborrheic dermatitis","otherDrugs":[{"name":"alclometasone dipropionate","slug":"alclometasone-dipropionate","company":""},{"name":"allantoin","slug":"allantoin","company":""},{"name":"amcinonide","slug":"amcinonide","company":"Astellas"},{"name":"ammonia","slug":"ammonia","company":""}],"globalPrevalence":null}],"mechanism":{"novelty":"First-in-class","modality":"Small Molecule","drugClass":"selenium sulfide","explanation":"","oneSentence":"","technicalDetail":"Selenium sulfide acts as an antifungal and antibacterial agent, exerting its effects by releasing ions that disrupt the cell membranes of fungi and yeast, ultimately leading to their death and resolution of infection."},"commercial":{"launchDate":"1951","_launchSource":"DrugCentral (FDA 1951-05-17, CHATTEM)"},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4274","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=SELENIUM%20SULFIDE","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=SELENIUM SULFIDE","fields":["publications"],"source":"PubMed/NCBI"},{"id":4,"url":"https://www.fda.gov/drugs/drug-approvals-and-databases/orange-book-data-files","fields":["patents","exclusivity","genericManufacturers"],"source":"FDA Orange Book"}],"_enrichedAt":"2026-03-30T15:36:31.499461","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T03:46:35.867162+00:00","fieldsConflicting":1,"overallConfidence":0.8},"biosimilars":[],"competitors":[{"drugName":"undecylenic acid","drugSlug":"undecylenic-acid","fdaApproval":"","relationship":"same-class"},{"drugName":"chlorphenesin 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dermatitis","source":"DrugCentral","snomedId":50563003,"regulator":"FDA","eligibility":"No specific eligibility criteria mentioned"}],"offLabel":[],"pipeline":[]},"currentOwner":"Chattem","drugCategory":"established","labelChanges":[],"patentStatus":"Off-patent — no active Orange Book patents","relatedDrugs":[{"drugId":"undecylenic-acid","brandName":"undecylenic acid","genericName":"undecylenic acid","approvalYear":"","relationship":"same-class"},{"drugId":"chlorphenesin-carbamate","brandName":"chlorphenesin carbamate","genericName":"chlorphenesin 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