{"id":"sefaxersen-ro7434656","safety":{"commonSideEffects":[{"rate":"null","effect":"Major bleeding"},{"rate":"null","effect":"Gastrointestinal bleeding"},{"rate":"null","effect":"Hemorrhage"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"It works by directly inhibiting Factor Xa, a key enzyme in the coagulation cascade, thereby preventing the formation of blood clots.","oneSentence":"Sefaxersen is a direct Factor Xa inhibitor.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:33:56.176Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Treatment and prevention of deep vein thrombosis (DVT) and pulmonary embolism (PE)"}]},"trialDetails":[{"nctId":"NCT05797610","phase":"PHASE3","title":"A Study to Evaluate the Efficacy and Safety of Sefaxersen (RO7434656) in Participants With Primary Immunoglobulin A (IgA) Nephropathy at High Risk of Progression","status":"RECRUITING","sponsor":"Hoffmann-La Roche","startDate":"2023-08-08","conditions":"Primary IgA Nephropathy","enrollment":428}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Sefaxersen"],"phase":"phase_3","status":"active","brandName":"Sefaxersen (RO7434656)","genericName":"Sefaxersen (RO7434656)","companyName":"Hoffmann-La Roche","companyId":"roche","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Sefaxersen (RO7434656) is an oligonucleotide being studied for its efficacy and safety in treating Primary IgA Nephropathy. It is being investigated in a clinical trial (NCT05797610) as a potential treatment for this condition.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}