{"id":"sedatives-hypnotics-other","safety":{"commonSideEffects":[{"rate":null,"effect":"Drowsiness/sedation"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Dependence/tolerance"},{"rate":null,"effect":"Cognitive impairment"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This drug class typically acts on GABAergic or other inhibitory pathways in the brain to depress central nervous system activity. By enhancing the effect of inhibitory neurotransmitters, these agents reduce neuronal excitability, leading to sedation, anxiolysis, and sleep induction. The specific molecular target depends on the individual agent within this broad class.","oneSentence":"Sedatives/hypnotics work by enhancing inhibitory neurotransmission in the central nervous system to promote sleep and reduce anxiety.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:07:18.854Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Insomnia"},{"name":"Anxiety disorders"}]},"trialDetails":[{"nctId":"NCT07398365","phase":"","title":"Medical Phenotyping of NHS General Adult Psychiatry (GAP) Inpatients","status":"RECRUITING","sponsor":"University of Edinburgh","startDate":"2024-04-03","conditions":"Bipolar Affective Disorder, Schizophrenia Disorders, Depression Disorders","enrollment":100},{"nctId":"NCT07325227","phase":"PHASE4","title":"Study of Remimazolam for Cataract Surgery","status":"NOT_YET_RECRUITING","sponsor":"Fred E, Shapiro","startDate":"2026-02-15","conditions":"Cataract Surgery Anesthesia","enrollment":30},{"nctId":"NCT07239687","phase":"","title":"A Comparative Study of Eleveld and Schnider Pharmacokinetic Models for Target-Controlled Infusion of Propofol in Sedation of Mechanically Ventilated ICU Patients","status":"RECRUITING","sponsor":"Hacettepe University","startDate":"2025-02-01","conditions":"Intensive Care Unit Sedation, Sedation, Target Controlled Infusion of Propofol","enrollment":84},{"nctId":"NCT06831942","phase":"NA","title":"Attempted Suicide Short Intervention Program for Older Adults (ASSIP-OA): An Evaluation of a Psychosocial Intervention for Suicidal Adults Aged 65+","status":"RECRUITING","sponsor":"Vastra Gotaland Region","startDate":"2025-10-01","conditions":"Suicidal Ideation, Suicide Attempt, Suicide","enrollment":132},{"nctId":"NCT01246765","phase":"","title":"National Pregnancy Registry for Psychiatric Medications","status":"RECRUITING","sponsor":"Massachusetts General Hospital","startDate":"2008-11","conditions":"Pregnant Women, Psychotropic Drugs","enrollment":5000},{"nctId":"NCT06584513","phase":"NA","title":"Improving Patient Safety by Supporting Older Adults in Managing Sleep Problems.","status":"RECRUITING","sponsor":"Insel Gruppe AG, University Hospital Bern","startDate":"2024-11-18","conditions":"Benzodiazepines Deprescribing, Sleep Problems","enrollment":470},{"nctId":"NCT03069638","phase":"PHASE4","title":"Intranasal Dexmedetomidine Sedation During Intra-articular Joint Injections in Pediatric Population","status":"COMPLETED","sponsor":"University of Oulu","startDate":"2017-02-01","conditions":"Juvenile Idiopathic Arthritis, Joint Inflammation","enrollment":68},{"nctId":"NCT06095258","phase":"PHASE2","title":"A Practical RCT of TCM in the Treatment of LCOVID and Analysis of Syndrome Types and Medication Characteristics.","status":"UNKNOWN","sponsor":"Chinese University of Hong Kong","startDate":"2023-12-01","conditions":"Long COVID","enrollment":162},{"nctId":"NCT04562324","phase":"NA","title":"Efficacy of Electroencephalography (EEG) Neurofeedback (NF) for the Treatment of Anxiety Disorder","status":"UNKNOWN","sponsor":"Tianjin Anding Hospital","startDate":"2019-09-10","conditions":"Anxiety Disorder, Healthy","enrollment":60},{"nctId":"NCT04856124","phase":"","title":"Intranasal Esketamine to Maintain the Antidepressant Response to IV Racemic Ketamine","status":"COMPLETED","sponsor":"Psych Atlanta","startDate":"2018-09-01","conditions":"Treatment Resistant Depression","enrollment":10},{"nctId":"NCT02033707","phase":"PHASE1","title":"Effects of Hallucinogens and Other Drugs on Mood and Performance","status":"COMPLETED","sponsor":"Johns Hopkins University","startDate":"2014-04","conditions":"Healthy","enrollment":20},{"nctId":"NCT02648776","phase":"","title":"Risk and Benefit Assessment of Hypnotic Agents for Sleep Disorders Among Elderly","status":"UNKNOWN","sponsor":"China Medical University Hospital","startDate":"2016-01","conditions":"Sleep Disorders","enrollment":1400},{"nctId":"NCT01350037","phase":"PHASE4","title":"Alfentanil Versus Remifentanil in Patient-controlled Sedation During Endoscopic Retrograde Cholangiopancreatography (ERCP)","status":"COMPLETED","sponsor":"Helsinki University Central Hospital","startDate":"2009-06","conditions":"Biliary Tract Diseases, Pancreatic Diseases","enrollment":81},{"nctId":"NCT00409344","phase":"PHASE4","title":"Dexmedetomidine for Postoperative Sedation in Patients Undergoing Repair of Thoracoabdominal Aortic Aneurysms","status":"TERMINATED","sponsor":"Massachusetts General Hospital","startDate":"2007-01","conditions":"Sedation, Respiration, Artificial, Length of Stay","enrollment":""}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":15644,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Dinitrous oxide"],"phase":"marketed","status":"active","brandName":"Sedatives/Hypnotics,Other","genericName":"Sedatives/Hypnotics,Other","companyName":"University of Oulu","companyId":"university-of-oulu","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Sedatives/hypnotics are used to treat conditions such as sleep disorders, sleep problems, and sedation in intensive care units. They can be administered through various interventions, including exposure to sedative-hypnotic drugs, specific tapering plans, and educational and cognitive behavioral therapy elements.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}