{"id":"sedative-analgesia-muscle-relaxant-therapy","safety":{"commonSideEffects":[{"rate":null,"effect":"Respiratory depression"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Bradycardia"},{"rate":null,"effect":"Delayed emergence from anesthesia"},{"rate":null,"effect":"Postoperative nausea and vomiting"}]},"_chembl":{"chemblId":"CHEMBL1290459","moleculeType":"Small molecule","molecularWeight":"328.16"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This is a therapeutic approach rather than a single drug entity, typically combining sedatives (such as benzodiazepines or propofol), opioid analgesics, and muscle relaxants (such as neuromuscular blocking agents) to achieve simultaneous sedation, analgesia, and skeletal muscle relaxation. The combination allows for reduced dosing of individual agents while achieving the desired clinical endpoints in perioperative or critical care settings.","oneSentence":"Sedative analgesia/muscle relaxant therapy combines central nervous system depressants and analgesics to produce sedation, pain relief, and muscle relaxation for clinical use.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:07:13.029Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Perioperative sedation and analgesia"},{"name":"Intensive care unit sedation and analgesia"},{"name":"Procedural sedation with muscle relaxation"}]},"trialDetails":[{"nctId":"NCT05525325","phase":"NA","title":"Mode of Sedation During Endovascular Treatment of Vertebrobasilar Stroke","status":"RECRUITING","sponsor":"University Hospital Heidelberg","startDate":"2022-10-01","conditions":"Stroke Thrombectomy","enrollment":128},{"nctId":"NCT05658692","phase":"PHASE4","title":"Platform Adaptive Embedded Trial for Acute Respiratory Distress Syndrome","status":"UNKNOWN","sponsor":"Second Affiliated Hospital, School of Medicine, Zhejiang University","startDate":"2022-10-01","conditions":"Acute Respiratory Distress Syndrome","enrollment":1000}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Propofol","midazolam","dexmedetomidine"],"phase":"marketed","status":"active","brandName":"Sedative analgesia/muscle relaxant therapy","genericName":"Sedative analgesia/muscle relaxant therapy","companyName":"Second Affiliated Hospital, School of Medicine, Zhejiang University","companyId":"second-affiliated-hospital-school-of-medicine-zhejiang-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Sedative analgesia/muscle relaxant therapy combines central nervous system depressants and analgesics to produce sedation, pain relief, and muscle relaxation for clinical use. Used for Perioperative sedation and analgesia, Intensive care unit sedation and analgesia, Procedural sedation with muscle relaxation.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":13,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}