{"id":"secondary-prophylaxis","safety":{"commonSideEffects":[{"rate":null,"effect":"Allergic reactions"}]},"_chembl":{"chemblId":"CHEMBL3545100","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Secondary prophylaxis involves administering a medication to prevent the recurrence of an infection that has already been treated. This approach is often used for conditions such as meningitis or sepsis, where the risk of recurrence is high.","oneSentence":"This drug is used to prevent the recurrence of certain infections.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:33:48.864Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of recurrent meningococcal disease"}]},"trialDetails":[{"nctId":"NCT06925737","phase":"PHASE3","title":"A Clinical Study of Ifinatamab Deruxtecan (I-DXd) in People With Metastatic Prostate Cancer (MK-2400-001)","status":"RECRUITING","sponsor":"Merck Sharp & Dohme LLC","startDate":"2025-05-13","conditions":"Prostate Cancer, Prostatic Neoplasms","enrollment":1440},{"nctId":"NCT07495631","phase":"NA","title":"Pediatric-Inspired Regimen Combined With Venetoclax and Immunotherapy for Adult Ph-Negative Acute Lymphoblastic Leukemia","status":"NOT_YET_RECRUITING","sponsor":"Institute of Hematology & Blood Diseases Hospital, China","startDate":"2026-03-01","conditions":"Acute Lymphoblastic Leukemia, Adult","enrollment":80},{"nctId":"NCT01306019","phase":"PHASE1, PHASE2","title":"Lentiviral Gene Transfer for Treatment of Children Older Than Two Years of Age With X-Linked Severe Combined Immunodeficiency (XSCID)","status":"RECRUITING","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2012-09-25","conditions":"X-linked Severe Combined Immunodeficiency (XSCID)","enrollment":40},{"nctId":"NCT03354741","phase":"NA","title":"Stimulation of Acupuncture Points by Athermic Laser Therapy for the Prevention of Chemotherapy Induced Nausea and Vomiting in Children","status":"COMPLETED","sponsor":"Centre Hospitalier Universitaire de Nice","startDate":"2019-05-23","conditions":"Children, Chemotherapy-induced Nausea and Vomiting, Malignant Tumor","enrollment":30},{"nctId":"NCT07498764","phase":"NA","title":"V-CARE (Virtual Care After REsuscitation)","status":"ENROLLING_BY_INVITATION","sponsor":"Mid and South Essex NHS Foundation Trust","startDate":"2024-08-01","conditions":"Health-Related Quality-of-Life, Satisfaction With Care, Self-management Behaviors","enrollment":50},{"nctId":"NCT04628026","phase":"PHASE3","title":"Phase III Study of Induction and Consolidation Chemotherapy With Venetoclax in Patients With Newly Diagnosed AML or MDS-EB-2","status":"RECRUITING","sponsor":"University of Ulm","startDate":"2022-09-13","conditions":"Acute Myeloid Leukemia","enrollment":650},{"nctId":"NCT07496320","phase":"NA","title":"Critical Food Ingredients on Immunocompetence to Prevent the Risk and Development of Obesity/Metabolic Syndrome","status":"COMPLETED","sponsor":"IMDEA Food","startDate":"2024-10-23","conditions":"Immunological Status, Healthy Volunteers, Healthy Volunteers - Male and Female","enrollment":60},{"nctId":"NCT06959771","phase":"PHASE1, PHASE2","title":"Base Editing Hematopoietic Stem Cell and T Cell Gene Therapy for CD40L-HyperIgM Syndrome: Single Patient Study","status":"RECRUITING","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2025-07-16","conditions":"CD40L-HyperIgM Syndrome","enrollment":1},{"nctId":"NCT07415148","phase":"NA","title":"Hyaluronic Acid and Albumin-PRF in Non-Surgical Periodontal Therapy","status":"ACTIVE_NOT_RECRUITING","sponsor":"Inonu University","startDate":"2025-04-09","conditions":"Periodontitis, Periodontal Inflammation","enrollment":51},{"nctId":"NCT05766046","phase":"NA","title":"Lung Cancer Prevention Screening Programme in Italy","status":"ACTIVE_NOT_RECRUITING","sponsor":"Ugo Pastorino","startDate":"2022-09-17","conditions":"Lung Cancer, COPD (Chronic Obstructive Pulmonary Disease) With Acute Lower Respiratory Infection, Cardiovascular Diseases","enrollment":7324},{"nctId":"NCT03228459","phase":"NA","title":"The ILERVAS Project: Assessing the Prevalence of Subclinical Vascular Disease and Hidden Kidney Disease","status":"ACTIVE_NOT_RECRUITING","sponsor":"Institut de Recerca Biomèdica de Lleida","startDate":"2015-01-15","conditions":"Atherosclerosis, Chronic Kidney Diseases, Metabolic Syndrome","enrollment":16660},{"nctId":"NCT05646589","phase":"NA","title":"A Person-centred Care Transition Support for People With Stroke/TIA","status":"COMPLETED","sponsor":"Karolinska Institutet","startDate":"2022-11-21","conditions":"Stroke, Transient Ischemic Attack","enrollment":213},{"nctId":"NCT06863272","phase":"PHASE1, PHASE2","title":"A Clinical Study of Ifinatamab Deruxtecan Based Treatment Combinations or as Monotherapy to Treat Metastatic Castrate Resistant Prostate Cancer (mCRPC) (MK-2400-01A/IDeate-Prostate02)","status":"RECRUITING","sponsor":"Merck Sharp & Dohme LLC","startDate":"2025-07-03","conditions":"Castration-Resistant Prostatic Cancer, Metastasis","enrollment":360},{"nctId":"NCT07493876","phase":"NA","title":"Enhanced Recovery After Surgery (ERAS) in Patients With Peritoneal Carcinomatosis Undergoing Cytoreductive Surgery With or Without HIPEC","status":"RECRUITING","sponsor":"Fondazione del Piemonte per l'Oncologia","startDate":"2025-01-23","conditions":"Peritoneal Carcinomatosis","enrollment":300},{"nctId":"NCT07493304","phase":"PHASE3","title":"Treatment and Secondary Prevention of Venous Thromboembolism (VTE) in Adult Participants With Solid and Hematologic Cancers","status":"NOT_YET_RECRUITING","sponsor":"Regeneron Pharmaceuticals","startDate":"2026-04-07","conditions":"Venous Thromboembolism (VTE)","enrollment":1600},{"nctId":"NCT04247191","phase":"NA","title":"Parent Intervention to Reduce College Student Drinking and Consequences","status":"COMPLETED","sponsor":"Penn State University","startDate":"2021-06-14","conditions":"Underage Drinking, Driving Under the Influence, Drinking, Teen","enrollment":2061},{"nctId":"NCT05373940","phase":"NA","title":"Cardioverter DefIbriIlator PlacEMent for priMary Prevention of Sudden cArdiac Death in Patients Older Than 70 Years","status":"RECRUITING","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2022-06-29","conditions":"Heart Failure, Primary Prevention of Sudden Cardiac Death, Implantable Cardioverter Defibrillator","enrollment":730},{"nctId":"NCT03633123","phase":"PHASE2","title":"D-PLEX 310: Safety and Efficacy of D-PLEX in the Prevention of Post Abdominal Surgery Incisional Infection","status":"COMPLETED","sponsor":"PolyPid Ltd.","startDate":"2018-10-04","conditions":"Abdominal Surgery, Colon Surgery, Post-Op Infection","enrollment":202},{"nctId":"NCT07486921","phase":"PHASE2","title":"Etrasimod as Prevention of Pouchitis","status":"NOT_YET_RECRUITING","sponsor":"Maia Kayal","startDate":"2026-03","conditions":"Pouchitis","enrollment":40},{"nctId":"NCT07487532","phase":"NA","title":"Acupuncture for Preventing Atrial Arrhythmia Recurrence After Ablation","status":"NOT_YET_RECRUITING","sponsor":"Shanghai Zhongshan Hospital","startDate":"2026-04-01","conditions":"Atrial Fibrillation (AF)","enrollment":120},{"nctId":"NCT07486089","phase":"PHASE1, PHASE2","title":"Dual-Target CAR-NK Cells for Advanced Breast Cancer (HER2+ and TNBC)","status":"RECRUITING","sponsor":"Beijing Biotech","startDate":"2026-02-02","conditions":"Breast Cancer (Locally Advanced or Metastatic), HER2-positive Breast Cancer, Triple-Negative Breast Cancer (TNBC)","enrollment":60},{"nctId":"NCT05884320","phase":"PHASE2","title":"Phase II Trial of Sacituzumab Govitecan in Recurrent and/or Metastatic Secretory Gland Cancers","status":"RECRUITING","sponsor":"M.D. Anderson Cancer Center","startDate":"2023-07-27","conditions":"Gland, Salivary Gland Cancers","enrollment":30},{"nctId":"NCT06768034","phase":"NA","title":"SecondarY Prevention and maNagement of Myocardial Injury aftER Noncardiac surGerY (SYNERGY) Pilot Trial","status":"NOT_YET_RECRUITING","sponsor":"Centre hospitalier de l'Université de Montréal (CHUM)","startDate":"2026-04","conditions":"Myocardial Injury After Noncardiac Surgery (MINS)","enrollment":100},{"nctId":"NCT05629845","phase":"NA","title":"Prevention of Variceal Rebleeding by EUS-guided vs Conventional Endoscopic Therapy in Hepatocellular Carcinoma Patients","status":"RECRUITING","sponsor":"Chinese University of Hong Kong","startDate":"2022-11-22","conditions":"Hepatocellular Carcinoma, Variceal Bleeding","enrollment":84},{"nctId":"NCT06732388","phase":"PHASE2","title":"Itraconazole in Combination With Ablation for the Prevention of Esophageal Cancer in Patients With High-risk Barrett's Esophagus","status":"NOT_YET_RECRUITING","sponsor":"National Cancer Institute (NCI)","startDate":"2026-02-16","conditions":"Barrett Esophagus, Clinical Stage I Esophageal Adenocarcinoma AJCC v8, Clinical Stage IIA Esophageal Adenocarcinoma AJCC v8","enrollment":64},{"nctId":"NCT04785443","phase":"PHASE3","title":"Contribution of ICG Angiography in the Detection of Parathyroids and the Prevention of Hypoparathyroidism Post Total Thyroidectomy","status":"RECRUITING","sponsor":"University Hospital, Brest","startDate":"2021-06-22","conditions":"Thyroid Diseases","enrollment":242},{"nctId":"NCT07482839","phase":"NA","title":"Feasibility Study of a Compassionate Mindful Resilience (CMR) Intervention to Improve Mental Health Well-being Outcomes Among Youth in Thailand","status":"NOT_YET_RECRUITING","sponsor":"Queen's University, Belfast","startDate":"2026-02-16","conditions":"Mental Health Well-being, Emotional Regulation, Psychological Resilience","enrollment":46},{"nctId":"NCT07130786","phase":"PHASE2","title":"Prophylactic Anti-Seizure Medication vs No Anti-Seizure Medication for Patients With Primary Motor Cortex Brain Metastases","status":"RECRUITING","sponsor":"Ayal A. Aizer, MD","startDate":"2025-12-23","conditions":"Seizures, Primary Motor Cortex, Brain Metastases From Non-small Cell Lung Cancer (NSCLC)","enrollment":150},{"nctId":"NCT06658405","phase":"PHASE2","title":"Clinical Trial Evaluating Secondary HPV Vaccination After Treatment of High-grade Cervical Lesions","status":"RECRUITING","sponsor":"Centre Oscar Lambret","startDate":"2025-01-13","conditions":"Cervical Lesion","enrollment":85},{"nctId":"NCT06013722","phase":"NA","title":"Strategy for Unstable Coronary Plaque in Patients Presenting to Emergency Department for Chest Pain Suspected of Coronary Artery Disease","status":"RECRUITING","sponsor":"Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer","startDate":"2024-03-18","conditions":"Atherosclerosis","enrollment":250},{"nctId":"NCT06980480","phase":"PHASE3","title":"A Study of Gammagard Liquid (Immune Globulin Infusion, 10%) to Prevent Infections in Adults With Multiple Myeloma","status":"RECRUITING","sponsor":"Takeda","startDate":"2026-01-14","conditions":"Multiple Myeloma, Secondary Immunodeficiency","enrollment":183},{"nctId":"NCT05964010","phase":"NA","title":"Primary Connections for Youth and Families","status":"RECRUITING","sponsor":"The National Center on Addiction and Substance Abuse at Columbia University","startDate":"2024-03-01","conditions":"Substance Use","enrollment":2300},{"nctId":"NCT03965234","phase":"PHASE1, PHASE2","title":"Pulmonary Suffusion in Controlling Minimal Residual Disease in Patients With Sarcoma or Colorectal Metastases","status":"RECRUITING","sponsor":"Roswell Park Cancer Institute","startDate":"2020-07-16","conditions":"Metastatic Bone Sarcoma, Metastatic Malignant Neoplasm in the Lung, Metastatic Soft Tissue Sarcoma","enrollment":99},{"nctId":"NCT05323955","phase":"PHASE2","title":"Secondary BRain Metastases Prevention After Isolated Intracranial Progression on Trastuzumab/Pertuzumab or T-DM1 in Patients With aDvanced Human Epidermal Growth Factor Receptor 2+ brEast Cancer With the Addition of Tucatinib","status":"ACTIVE_NOT_RECRUITING","sponsor":"Carey Anders, M.D.","startDate":"2023-03-23","conditions":"Brain Metastases, Human Epidermal Growth Factor 2 Positive Carcinoma of Breast, Advanced Breast Cancer","enrollment":48},{"nctId":"NCT06859424","phase":"PHASE2","title":"A Platform Protocol to Investigate Post-Transplant Cyclophosphamide-Based Graft-Versus-Host Disease Prophylaxis in Patients With Hematologic Malignancies Undergoing Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation","status":"RECRUITING","sponsor":"Center for International Blood and Marrow Transplant Research","startDate":"2025-07-25","conditions":"AML (Acute Myelogenous Leukemia), Acute Lymphoid Leukemia (ALL), Acute Leukemia (Category)","enrollment":358},{"nctId":"NCT07472660","phase":"NA","title":"Intensive Prevention Program After Decompensated Heart Failure","status":"RECRUITING","sponsor":"Herzzentrum Bremen","startDate":"2025-10-01","conditions":"Heart Failure","enrollment":200},{"nctId":"NCT07475013","phase":"NA","title":"Effects of Non-Surgical Periodontal Treatment on Inflammatory and Bone Markers in Periodontitis Patients","status":"NOT_YET_RECRUITING","sponsor":"Saglik Bilimleri Universitesi","startDate":"2026-03-15","conditions":"Periodontitis (Stage 3)","enrollment":56},{"nctId":"NCT01613482","phase":"PHASE3","title":"TraStuzumAb-Radiotherapy : Impact on the Cerebral Prevention","status":"TERMINATED","sponsor":"Centre Oscar Lambret","startDate":"2008-01","conditions":"Breast Cancer, Metastasis, Sur-expressing Her2-neu","enrollment":13},{"nctId":"NCT07286149","phase":"PHASE1, PHASE2","title":"A Clinical Study of MK-1084 With Other Treatments for Non-small Cell Lung Cancer (MK-3475-01F)","status":"RECRUITING","sponsor":"Merck Sharp & Dohme LLC","startDate":"2026-03-23","conditions":"Lung Neoplasm Malignant","enrollment":190},{"nctId":"NCT05811351","phase":"PHASE2","title":"A Study to Evaluate Intravitreal JNJ-81201887 (AAVCAGsCD59) Compared to Sham Procedure for the Treatment of Geographic Atrophy (GA) Secondary to Age-related Macular Degeneration (AMD)","status":"COMPLETED","sponsor":"Janssen Research & Development, LLC","startDate":"2023-03-06","conditions":"Geographic Atrophy","enrollment":305},{"nctId":"NCT05262426","phase":"NA","title":"Developing mHealth to Promote PrEP Use Among Thai Young Vulnerable Adolescents and Emerging Adults","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of Massachusetts, Worcester","startDate":"2021-12-27","conditions":"Pre-Exposure Prophylaxis","enrollment":145},{"nctId":"NCT06408220","phase":"NA","title":"Risk Assessment Evaluation for Identifying Participants at High Risk for Stomach Cancer","status":"RECRUITING","sponsor":"City of Hope Medical Center","startDate":"2024-06-27","conditions":"Gastric Carcinoma","enrollment":240},{"nctId":"NCT07459673","phase":"PHASE2","title":"HERizon-Breast: A ctDNA-Guided Adaptive Study of Sequential Anti-HER2 Therapies and CNS Prophylaxis to Induce Long-Term Remission","status":"RECRUITING","sponsor":"Memorial Sloan Kettering Cancer Center","startDate":"2026-03-04","conditions":"Breast Cancer, HER2-positive Breast Cancer, Breast Cancer Stage IV","enrollment":60},{"nctId":"NCT06835751","phase":"NA","title":"Optimizing HIV Pre-exposure Prophylaxis (PrEP) Among Women Who Use Drugs in Tanzania","status":"ACTIVE_NOT_RECRUITING","sponsor":"Johns Hopkins Bloomberg School of Public Health","startDate":"2025-07-25","conditions":"HIV, Mental Health, Substance Use (Drugs, Alcohol)","enrollment":200},{"nctId":"NCT06384521","phase":"NA","title":"Lifestyle MIND- Feasibility of Wait-list Control","status":"WITHDRAWN","sponsor":"The University of Texas Health Science Center at San Antonio","startDate":"2025-12","conditions":"Type 2 Diabetes Mellitus, Serious Mental Illness, Schizophrenia","enrollment":""},{"nctId":"NCT07464574","phase":"","title":"Optimizing Non-statin Agents for ASCVD","status":"RECRUITING","sponsor":"University of Texas at Austin","startDate":"2026-01-16","conditions":"ASCVD Management","enrollment":1000},{"nctId":"NCT05751187","phase":"PHASE2","title":"Pembrolizumab Plus Bevacizumab and Chemotherapy for Non-Squamous NSCLC Patients","status":"ACTIVE_NOT_RECRUITING","sponsor":"Shanghai Chest Hospital","startDate":"2023-06-27","conditions":"Non-squamous NSCLC","enrollment":54},{"nctId":"NCT03036930","phase":"PHASE2","title":"Preventive Human Papillomavirus (HPV) Vaccine Trial in Kidney Transplant Recipients","status":"ACTIVE_NOT_RECRUITING","sponsor":"National Cancer Institute (NCI)","startDate":"2017-06-23","conditions":"Human Papillomavirus Infection, Human Papillomavirus-Related Carcinoma","enrollment":51},{"nctId":"NCT06154226","phase":"PHASE2","title":"Prevention of Post-Cardiac Surgery Acute Kidney Injury by Proton Pump Inhibitor","status":"COMPLETED","sponsor":"The University of Texas Health Science Center, Houston","startDate":"2024-01-10","conditions":"Acute Kidney Injury","enrollment":100},{"nctId":"NCT06096519","phase":"NA","title":"Effectiveness and Implementation of Text Messaging to Improve HIV Testing in Adolescents","status":"RECRUITING","sponsor":"Northwestern University","startDate":"2024-06-13","conditions":"HIV","enrollment":360},{"nctId":"NCT04384692","phase":"PHASE2","title":"Peritransplant Ruxolitinib for Patients With Primary and Secondary Myelofibrosis","status":"ACTIVE_NOT_RECRUITING","sponsor":"Fred Hutchinson Cancer Center","startDate":"2020-12-18","conditions":"Primary Myelofibrosis, Secondary Myelofibrosis","enrollment":53},{"nctId":"NCT07414732","phase":"NA","title":"Testing the Effectiveness of a Novel Intervention to Improve Medication Adherence in Stroke Survivors","status":"RECRUITING","sponsor":"Massachusetts General Hospital","startDate":"2026-03-10","conditions":"Stroke, Intracerebral Haemorrhage, Ischemic Stroke","enrollment":150},{"nctId":"NCT06702878","phase":"PHASE3","title":"Light-Activated Antimicrobial Therapy to Prevent Surgical Site Infections","status":"RECRUITING","sponsor":"Ondine Biomedical Inc.","startDate":"2024-12-27","conditions":"Surgical Site Infections, Surgical Wound Infection, Infections","enrollment":4514},{"nctId":"NCT07454707","phase":"PHASE3","title":"Testing a New Treatment Strategy to Improve Secondary Stroke Prevention for Older Adults: The STROKE75+ Trial","status":"NOT_YET_RECRUITING","sponsor":"Sunnybrook Health Sciences Centre","startDate":"2026-04","conditions":"Stroke, Ischemic","enrollment":1204},{"nctId":"NCT07455318","phase":"PHASE3","title":"Boostability Assessment of Three Rabies Pre-Exposure Regimens in Healthy Volunteers 5 Years Following Priming.","status":"NOT_YET_RECRUITING","sponsor":"Institute of Tropical Medicine, Belgium","startDate":"2026-05-15","conditions":"Rabies (Healthy Volunteers)","enrollment":561},{"nctId":"NCT07452978","phase":"PHASE2","title":"Propranolol for Early Secondary Prevention of Post-Traumatic Stress Disorder in Women Victims of Sexual Violence","status":"NOT_YET_RECRUITING","sponsor":"University Hospital, Tours","startDate":"2026-09-01","conditions":"PTSD - Post Traumatic Stress Disorder","enrollment":34},{"nctId":"NCT07189858","phase":"NA","title":"Light-Activated Antimicrobial Therapy to Prevent Surgical Site Infections - Canada","status":"RECRUITING","sponsor":"Ondine Biomedical Inc.","startDate":"2026-01-13","conditions":"Surgical Site Infections, Infections, Surgical Wound Infections","enrollment":4740},{"nctId":"NCT05243030","phase":"NA","title":"Developing mHealth to Promote PrEP Use Among Thai Young Men Who Have Sex With Men","status":"COMPLETED","sponsor":"University of Massachusetts, Worcester","startDate":"2022-02-23","conditions":"Pre-Exposure Prophylaxis","enrollment":119},{"nctId":"NCT04335890","phase":"PHASE1","title":"IKKb-matured, RNA-loaded Dendritic Cells for Metastasised Uveal Melanoma","status":"COMPLETED","sponsor":"Hasumi International Research Foundation","startDate":"2020-09-24","conditions":"Melanoma, Uveal Metastatic","enrollment":17},{"nctId":"NCT02333162","phase":"PHASE1","title":"Intensity Modulated Total Marrow Irradiation, Fludarabine Phosphate, and Melphalan in Treating Patients With Relapsed Hematologic Cancers Undergoing a Second Donor Stem Cell Transplant","status":"RECRUITING","sponsor":"University of Chicago","startDate":"2014-12-05","conditions":"Previously Treated Myelodysplastic Syndrome, Recurrent Adult Acute Lymphoblastic Leukemia, Recurrent Adult Acute Myeloid Leukemia","enrollment":30},{"nctId":"NCT07430826","phase":"NA","title":"Building Opportunities for Nurturing Care to Enhance Child Development in Eastern and Southern Africa","status":"NOT_YET_RECRUITING","sponsor":"University of Washington","startDate":"2026-11","conditions":"Neurodevelopment, Child Growth","enrollment":1260},{"nctId":"NCT05975385","phase":"NA","title":"Acupuncture for Prevention of Postoperative Nausea and Vomiting After Laparoscopic Cholecystectomy","status":"COMPLETED","sponsor":"Baylor College of Medicine","startDate":"2023-10-09","conditions":"Cholecystitis, Acute, Cholelithiasis, Nausea, Postoperative","enrollment":270},{"nctId":"NCT07031089","phase":"","title":"City-Hospital Collaboration for Early Detection of Liver Fibrosis in Primary Care: A Secondary Prevention Project in the Grenoble Health Area","status":"RECRUITING","sponsor":"University Hospital, Grenoble","startDate":"2026-01-14","conditions":"Liver Fibrosis","enrollment":150},{"nctId":"NCT06236087","phase":"","title":"Overdose Prevention Centers and Behavioral Health","status":"NOT_YET_RECRUITING","sponsor":"NYU Langone Health","startDate":"2026-09-01","conditions":"Overdose","enrollment":500},{"nctId":"NCT07442357","phase":"NA","title":"The Per-procedural Antibiotic Prophylaxis in Patients Undergoing Transcatheter Aortic Valve Implantation Trial","status":"NOT_YET_RECRUITING","sponsor":"Rigshospitalet, Denmark","startDate":"2026-06-01","conditions":"Aortic Valve Stenosis","enrollment":1986},{"nctId":"NCT07420374","phase":"NA","title":"Ambulatory Stroke Unit Treatment for Elderly Patients","status":"NOT_YET_RECRUITING","sponsor":"University Hospital Heidelberg","startDate":"2026-04","conditions":"Ischemic Stroke, Transient Ischemic Attack (TIA), Retinal Ischemia","enrollment":400},{"nctId":"NCT07265830","phase":"PHASE3","title":"Building Adaptive School-based Interventions for Caries","status":"NOT_YET_RECRUITING","sponsor":"University of Pennsylvania","startDate":"2026-09","conditions":"Dental Caries","enrollment":1200},{"nctId":"NCT07431502","phase":"PHASE3","title":"Trial to Evaluate Nonavalent HPV Vaccine as a Secondary Prevention in Patients Treated for Human Papilloma Virus Related High-grade Squamous Intraepithelial Lesions","status":"NOT_YET_RECRUITING","sponsor":"Gustave Roussy, Cancer Campus, Grand Paris","startDate":"2026-05","conditions":"Patients With Primary HPV High-grade Squamous Intra-epithelial Lesions (HSIL) at Vulvar Site, Patients With Primary HPV High-grade Squamous Intra-epithelial Lesions (HSIL) at Vaginal Site, Patients With Primary HPV High-grade Squamous Intra-epithelial Lesions (HSIL) at Penile Site","enrollment":984},{"nctId":"NCT07438574","phase":"NA","title":"Throwers Ten Exercise Program Versus Shoulder Strengthening Exercises on Performance in Overhead Throwing Athletes.","status":"COMPLETED","sponsor":"Riphah International University","startDate":"2024-10-18","conditions":"Sports Physical Therapy","enrollment":36},{"nctId":"NCT06018181","phase":"","title":"Outcomes After Intravenous Alteplase / Tenecteplase With or Without Shuxuetong Injection in Routine Clinical Practice","status":"COMPLETED","sponsor":"Dongzhimen Hospital, Beijing","startDate":"2023-09-28","conditions":"Ischemic Stroke, Acute","enrollment":2408},{"nctId":"NCT06488105","phase":"PHASE2","title":"Emergency Medicine Cardiovascular Risk Assessment for Lipid Disorders Trial","status":"RECRUITING","sponsor":"Wake Forest University Health Sciences","startDate":"2024-08-05","conditions":"Lipid Disorder, Hypercholesterolemia, Cardiovascular Diseases","enrollment":130},{"nctId":"NCT06942429","phase":"NA","title":"Stepped Versus Stratified Care for Anxiety Disorders in Youth","status":"RECRUITING","sponsor":"Region Skane","startDate":"2025-06-19","conditions":"Social Anxiety Disorder, Separation Anxiety Disorder, Specific Phobia","enrollment":556},{"nctId":"NCT05125016","phase":"PHASE1, PHASE2","title":"A Trial to Find Out if REGN4336 is Safe and How Well it Works Alone and in Combination With Cemiplimab or REGN5678 for Adult Participants With Advanced Prostate Cancer","status":"RECRUITING","sponsor":"Regeneron Pharmaceuticals","startDate":"2021-11-30","conditions":"Metastatic Castration-resistant Prostate Cancer","enrollment":370},{"nctId":"NCT03640208","phase":"NA","title":"Educate, Assess Risk and Overcoming Barriers to Colorectal Screening Among African Americans","status":"COMPLETED","sponsor":"Case Comprehensive Cancer Center","startDate":"2019-02-27","conditions":"Colorectal Cancer","enrollment":163},{"nctId":"NCT07123064","phase":"NA","title":"Alleviating Loneliness in Older Adults Living in Poverty: A Multi-level Intervention","status":"NOT_YET_RECRUITING","sponsor":"Education University of Hong Kong","startDate":"2026-04-01","conditions":"Loneliness, Poverty","enrollment":1344},{"nctId":"NCT07440381","phase":"PHASE3","title":"triPle Oral thERapy With Bempedoic Acid vs uSual Care in Early Lipid Management of Patients With acUte coronAry synDromE","status":"NOT_YET_RECRUITING","sponsor":"Heart Care Foundation","startDate":"2026-09","conditions":"Acute Coronary Syndromes, Secondary Prevention, Lipids","enrollment":600},{"nctId":"NCT07432438","phase":"NA","title":"Online Suicide Prevention and Intervention Training for Secondary School Counselors","status":"RECRUITING","sponsor":"Aydin Adnan Menderes University","startDate":"2026-01-01","conditions":"Suicide Prevention, Suicidal Ideation, School Counseling","enrollment":60},{"nctId":"NCT06513962","phase":"PHASE3","title":"Triptorelin for the Prevention of Ovarian Damage in Adolescents and Young Adults With Cancer","status":"RECRUITING","sponsor":"Children's Oncology Group","startDate":"2025-02-27","conditions":"Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm","enrollment":60},{"nctId":"NCT07426822","phase":"PHASE2","title":"Rash & Diarrhea Prophylaxis With Capivasertib","status":"NOT_YET_RECRUITING","sponsor":"Maryam Lustberg","startDate":"2026-04","conditions":"Metastatic HR+/HER2- Breast Cancer","enrollment":108},{"nctId":"NCT07429409","phase":"NA","title":"Cancer Risk Factor Knowledge Among Teenagers in Slovenia","status":"COMPLETED","sponsor":"Institute of Oncology Ljubljana","startDate":"2021-12-01","conditions":"Cancer Prevention, Cancer Risk Factors","enrollment":795},{"nctId":"NCT05997264","phase":"PHASE2","title":"Anthrax AV7909 Boost Evaluation Study","status":"ACTIVE_NOT_RECRUITING","sponsor":"Biomedical Advanced Research and Development Authority","startDate":"2023-12-05","conditions":"Anthrax","enrollment":220},{"nctId":"NCT07209917","phase":"NA","title":"Secondary Cervical Cancer Prevention of Vulnerable Women With HPV and HIV Co-infection in India","status":"RECRUITING","sponsor":"University of California, Irvine","startDate":"2026-02-01","conditions":"Cervical Cancer, Human Papillomavirus (HPV) Infection, Human Immunodeficiency Virus (HIV) Infection","enrollment":420},{"nctId":"NCT07423975","phase":"PHASE2","title":"Advancing Reperfusion Therapy for Ischemic Stroke: Safety and Efficacy of Anakinra for Futile Reperfusion Following Endovascular Treatment in Patients With Acute Ischemic Stroke","status":"NOT_YET_RECRUITING","sponsor":"Beijing Tiantan Hospital","startDate":"2026-03-01","conditions":"Stroke Acute, Endovascular Treatment","enrollment":159},{"nctId":"NCT00544466","phase":"PHASE1, PHASE2","title":"Helical Tomotherapy, Fludarabine Phosphate, and Melphalan Followed By Allo-HSCT in Hematological Malignancies","status":"ACTIVE_NOT_RECRUITING","sponsor":"City of Hope Medical Center","startDate":"2006-07-31","conditions":"Leukemia, Myelodysplastic Syndromes","enrollment":75},{"nctId":"NCT04563520","phase":"PHASE3","title":"SAFE Study: Safety of aPCC Following Emicizumab Prophylaxis","status":"RECRUITING","sponsor":"Emory University","startDate":"2026-03","conditions":"Hemophilia A","enrollment":5},{"nctId":"NCT07418879","phase":"NA","title":"A Real-world Study of Pralsetinib Combined With Leucogen in the Treatment of RET Fusion-positive NSCLC","status":"NOT_YET_RECRUITING","sponsor":"Fudan University","startDate":"2026-02-05","conditions":"Non-small Cell Lung Cancer, RET Fusion, Pralsetinib","enrollment":25},{"nctId":"NCT05660083","phase":"PHASE2","title":"Alpelisib/iNOS Inhibitor/Nab-paclitaxel in Patients With HER2 Negative Metaplastic Breast Cancer (MpBC)","status":"RECRUITING","sponsor":"The Methodist Hospital Research Institute","startDate":"2023-01-12","conditions":"HER2-negative Breast Cancer, Metastatic Breast Cancer, Metaplastic Breast Carcinoma","enrollment":36},{"nctId":"NCT06864689","phase":"EARLY_PHASE1","title":"Leveraging Video Logs as a Bridge to Pre-exposure Prophylaxis (PrEP) With Tailored Messaging to Black Women and Their Healthcare Providers in Texas.","status":"NOT_YET_RECRUITING","sponsor":"The University of Texas Medical Branch, Galveston","startDate":"2026-09","conditions":"HIV Prevention","enrollment":78},{"nctId":"NCT05656976","phase":"NA","title":"Efficacy of Offering a Self-sampling Device by the GP to Reach Underscreened Women","status":"ACTIVE_NOT_RECRUITING","sponsor":"University Ghent","startDate":"2023-09-01","conditions":"Cervical Cancer","enrollment":3375},{"nctId":"NCT06224673","phase":"PHASE2","title":"ARX788 for Treating Patients With HER2-low Locally Advanced Unresectable or Metastatic Breast Cancer","status":"NOT_YET_RECRUITING","sponsor":"Laura Huppert, MD, BA","startDate":"2026-03-01","conditions":"HER2 Low Breast Carcinoma, Triple Negative Breast Cancer, Hormone-receptor-positive Breast Cancer","enrollment":36},{"nctId":"NCT06284265","phase":"PHASE3","title":"Clinical Trial of the Efficacy and Safety of Raphamin in Prevention of Recurrences of Chronic Bacterial Cystitis","status":"ACTIVE_NOT_RECRUITING","sponsor":"Materia Medica Holding","startDate":"2023-10-16","conditions":"Cystitis Chronic, Cystitis Bacterial, Recurrence of Chronic Bacterial Cystitis","enrollment":415},{"nctId":"NCT06300957","phase":"NA","title":"Help Wanted: Evaluating a Prevention Intervention for People With Sexual Interest in Children","status":"COMPLETED","sponsor":"Johns Hopkins Bloomberg School of Public Health","startDate":"2023-10-24","conditions":"Program Evaluation, Child Sexual Abuse, Perpetration of Child Sexual Abuse","enrollment":147},{"nctId":"NCT07411287","phase":"NA","title":"Gut Microbiota Modulation With Synbiotics After Acute Coronary Syndrome","status":"NOT_YET_RECRUITING","sponsor":"Centre Hospitalier de Bienne","startDate":"2026-06-01","conditions":"Atheroscleroses, Coronary, Microbiota","enrollment":80},{"nctId":"NCT07405736","phase":"PHASE2","title":"Lubiprostone Combined With Maintenance Therapy for Prevention of Postoperative Recurrence in Peritoneal Metastatic Colorectal Cancer","status":"NOT_YET_RECRUITING","sponsor":"Sun Yat-sen University","startDate":"2026-02-24","conditions":"Colorectal Cancer Metastatic, Peritoneal (Metastatic) Cancer, Peritoneal Metastasis","enrollment":124},{"nctId":"NCT06943404","phase":"PHASE2","title":"BXCL501 After Stress to Increase Recovery Success","status":"NOT_YET_RECRUITING","sponsor":"University of North Carolina, Chapel Hill","startDate":"2026-02-11","conditions":"Acute Stress Reaction, Acute Stress Disorder, Post-traumatic Stress Disorder","enrollment":100},{"nctId":"NCT07402642","phase":"NA","title":"Effect of Early Educational Intervention on Cardiovascular Risk Factors After Acute Coronary Syndrome","status":"RECRUITING","sponsor":"Sergio Mies Padilla","startDate":"2026-01-12","conditions":"Myocardial Infarction","enrollment":256},{"nctId":"NCT03461874","phase":"NA","title":"ACT Therapy for HF Migraine","status":"COMPLETED","sponsor":"Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta","startDate":"2018-03-15","conditions":"Migraine Without Aura","enrollment":64},{"nctId":"NCT07404410","phase":"NA","title":"Robotic Technologies for APATHy in Dementia: a Randomised Controlled Trial (RAPHAel)","status":"NOT_YET_RECRUITING","sponsor":"Giovanna Zamboni","startDate":"2026-02-16","conditions":"Apathy, Apathy in Dementia","enrollment":75},{"nctId":"NCT07401940","phase":"NA","title":"HAVEN-Connect Youth Suicide Prevention","status":"RECRUITING","sponsor":"George Washington University","startDate":"2023-06-01","conditions":"Suicide Prevention","enrollment":240},{"nctId":"NCT06906666","phase":"","title":"Analysis of Injury Risk Factors in Elite Athletes","status":"COMPLETED","sponsor":"University of Oviedo","startDate":"2025-03-31","conditions":"Athletic Injuries","enrollment":81}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2511,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Secondary Prophylaxis","genericName":"Secondary Prophylaxis","companyName":"Children's Hospital Medical Center, Cincinnati","companyId":"children-s-hospital-medical-center-cincinnati","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This drug is used to prevent the recurrence of certain infections. Used for Prevention of recurrent meningococcal disease.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}