{"id":"secalciferol","rwe":[{"pmid":"40225420","year":"2025","title":"In silico docking, ADMET profiling, and bio-accessibility experimentation on Breynia retusa phytocompounds and in vitro validation for anti-proliferative potencies against ovarian carcinoma.","finding":"","journal":"3 Biotech","studyType":"Clinical Study"}],"tags":[{"label":"secalciferol","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":["NCT06842368"],"aliases":[],"patents":[],"pricing":[],"allNames":"osteo d","offLabel":[],"synonyms":["Osteo D","secalciferol"],"timeline":[],"approvals":[],"brandName":"Osteo D","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"secalciferol","explanation":"Imagine your body has a special lock that only opens with a specific key. Vitamin D receptors are like those locks, and secalciferol is the key that fits perfectly. When secalciferol binds to these receptors, it sends a signal to the body to increase the production of calcium and phosphate, which are essential for building and maintaining strong bones.","oneSentence":"Secalciferol works by binding to vitamin D receptors in the body, triggering a response that increases calcium and phosphate levels.","technicalDetail":"Secalciferol acts as a selective vitamin D receptor modulator, activating the vitamin D receptor (VDR) to regulate the expression of genes involved in calcium and phosphate homeostasis, ultimately leading to increased intestinal absorption of calcium and phosphate."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/2426","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=SECALCIFEROL","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:38:42.632897","biosimilars":[],"competitors":[],"dataSources":[{"url":"https://clinicaltrials.gov","name":"ClinicalTrials.gov","fields":["trialDetails","trials"],"retrievedDate":"2026-04-07"},{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"secalciferol","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT06842368","phase":"NA","title":"Immediate Implant Placement Using Xenograft As Space Filling Material Mixed with Vitamin D Versus Hyaluronic Acid in Posterior Mandible Region: a Randomized Controlled Clinical Trial.","status":"RECRUITING","sponsor":"Cairo University","isPivotal":false,"enrollment":24,"indication":"Immediate Implant Placement","completionDate":"2025-10-30"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"UNII":"460029IUDA","CHEBI":"CHEBI:28818","INN_ID":"6502","UMLSCUI":"C4726736","ChEMBL_ID":"CHEMBL1590076","KEGG_DRUG":"D00628","PUBCHEM_CID":"5283748"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":1,"therapeuticAreas":["Bone"],"biosimilarFilings":[],"recentPublications":[{"date":"2025 May","pmid":"40225420","title":"In silico docking, ADMET profiling, and bio-accessibility experimentation on Breynia retusa phytocompounds and in vitro validation for anti-proliferative potencies against ovarian carcinoma.","journal":"3 Biotech"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Osteo D (Secalciferol) is a small molecule drug in the secalciferol class, used to treat vitamin D deficiency. It works by stimulating the production of calcium and phosphate in the body, which is essential for bone growth and maintenance. The commercial status of Osteo D is unknown, and it is not clear if it is patented or generic. Key safety considerations include potential interactions with other medications and monitoring of calcium levels. Secalciferol is a form of vitamin D that is naturally produced in the skin upon exposure to sunlight.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}