{"id":"sdd-gastric-suspension","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal tolerance issues"},{"rate":null,"effect":"Taste disturbance"}]},"_chembl":{"chemblId":"CHEMBL2108517","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"Selective decontamination of the digestive tract (SDD) is a strategy to prevent infections in critically ill patients by reducing gram-negative aerobic bacteria and fungi in the gastrointestinal tract. The gastric suspension formulation targets the stomach specifically, aiming to lower infection rates and improve clinical outcomes in high-risk populations without causing systemic antibiotic resistance.","oneSentence":"SDD Gastric Suspension selectively decontaminates the stomach by delivering antimicrobial agents to reduce pathogenic bacteria while preserving beneficial flora.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:33:41.342Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of infections in critically ill patients (Phase 3 development)"}]},"trialDetails":[{"nctId":"NCT02389036","phase":"PHASE3","title":"Selective Decontamination of the Digestive Tract in Intensive Care Unit Patients","status":"COMPLETED","sponsor":"The George Institute","startDate":"2017-05-01","conditions":"Critical Illness, Sepsis, Septic Shock","enrollment":20010}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":3,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Colistin, Tobramycin and Nystatin"],"phase":"phase_3","status":"active","brandName":"SDD Gastric Suspension","genericName":"SDD Gastric Suspension","companyName":"The George Institute","companyId":"the-george-institute","modality":"Small molecule","firstApprovalDate":"","aiSummary":"SDD Gastric Suspension selectively decontaminates the stomach by delivering antimicrobial agents to reduce pathogenic bacteria while preserving beneficial flora. Used for Prevention of infections in critically ill patients (Phase 3 development).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}