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This process gradually fills in wrinkles and folds while improving skin quality, with results developing over several weeks to months as collagen remodeling occurs.","oneSentence":"Sculptra Aesthetic stimulates collagen production in the skin through a biostimulatory effect, gradually restoring facial volume and improving skin texture.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:07:01.024Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Facial wrinkles and folds (nasolabial folds, marionette lines, chin wrinkles)"},{"name":"Loss of facial volume and skin laxity"}]},"trialDetails":[{"nctId":"NCT07205744","phase":"PHASE4","title":"Post-Menopause Skin Rejuvenation Study","status":"ACTIVE_NOT_RECRUITING","sponsor":"Erevna Innovations Inc.","startDate":"2025-08-14","conditions":"Aesthetic, Menopause, Post-menopause","enrollment":50},{"nctId":"NCT07217743","phase":"PHASE2","title":"Assess Impact of Poly-L-lactic Acid on GLP1 Subjects","status":"NOT_YET_RECRUITING","sponsor":"Goldman, Butterwick, Fitzpatrick and Groff","startDate":"2025-10-27","conditions":"Laxity; Skin","enrollment":20},{"nctId":"NCT07202117","phase":"PHASE4","title":"PLLA and CaHA-R for Aesthetic Rejuvenation","status":"RECRUITING","sponsor":"Erevna Innovations Inc.","startDate":"2025-11-01","conditions":"Aesthetic","enrollment":45},{"nctId":"NCT04595331","phase":"NA","title":"Open Label Extension for 43USSA1812","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2019-11-12","conditions":"Cheek, Wrinkle","enrollment":111},{"nctId":"NCT04225273","phase":"NA","title":"Extension Study for 43USSA1705","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2019-12-03","conditions":"Nasolabial Folds","enrollment":38},{"nctId":"NCT05215054","phase":"NA","title":"Clinical Study for the Evaluation of the Safety and Effectiveness of Use of a Poly-L Lactic Acid Injectable Filler for the Aesthetic Treatment of Nasolabial Folds","status":"COMPLETED","sponsor":"GCS Co., Ltd","startDate":"2022-03-07","conditions":"Wrinkle","enrollment":59},{"nctId":"NCT02310490","phase":"NA","title":"DA-13-007 Versus Sculptra for the Treatment of Nasolabial Folds Wrinkles","status":"COMPLETED","sponsor":"DermAvance","startDate":"2015-01","conditions":"Face; Atrophy","enrollment":161},{"nctId":"NCT04124692","phase":"NA","title":"Safety and Effectiveness of Sculptra Aesthetic for Correction of Cheek Wrinkles","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2019-11-12","conditions":"Cheek Wrinkles","enrollment":149},{"nctId":"NCT02425943","phase":"PHASE4","title":"Sculptra Aesthetic Post-Approval Study","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2015-05-21","conditions":"Nasolabial Fold Contour Deficiencies, Wrinkles","enrollment":867},{"nctId":"NCT03780244","phase":"NA","title":"Safety and Effectiveness of Sculptra Aesthetic for Correction of Nasolabial Folds.","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2018-12-18","conditions":"Nasolabial Folds","enrollment":80},{"nctId":"NCT05608239","phase":"NA","title":"Safety and Efficacy of Injectable Poly-L-Lactic Acid for Volume Loss in the Temples Using Dual Plane Injections","status":"UNKNOWN","sponsor":"Sadick Research Group","startDate":"2022-11","conditions":"Lipoatrophy, Aging","enrollment":20},{"nctId":"NCT05463978","phase":"","title":"Sculptra Chart Review","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2022-07-14","conditions":"Non-facial Skin Aesthetic Conditions","enrollment":500},{"nctId":"NCT05445661","phase":"NA","title":"Sculptra to Aid in Treatment of Arm Laxity","status":"UNKNOWN","sponsor":"Goldman, Butterwick, Fitzpatrick and Groff","startDate":"2022-07-20","conditions":"Skin Laxity","enrollment":20},{"nctId":"NCT05269654","phase":"NA","title":"Injectable Poly-L-Lactic Acid for Volumization and Adipogenesis of the Hip Dell","status":"UNKNOWN","sponsor":"Goldman, Butterwick, Fitzpatrick and Groff","startDate":"2022-03-04","conditions":"Skin Laxity","enrollment":20},{"nctId":"NCT04957446","phase":"NA","title":"Histology Study of Biostimulatory Activity of Injectable Poly-L-Lactic Acid (Sculptra Aesthetic)","status":"UNKNOWN","sponsor":"Sadick Research Group","startDate":"2021-08-09","conditions":"Nasolabial Fold, Facial Wrinkles","enrollment":10},{"nctId":"NCT04830722","phase":"NA","title":"Clinical Trial of Poly-L-lactic Acid (Sculptra Aesthetic) for the Treatment of Cellulite of the Buttocks and Thighs","status":"UNKNOWN","sponsor":"Goldman, Butterwick, Fitzpatrick and Groff","startDate":"2021-04-09","conditions":"Cellulite","enrollment":20},{"nctId":"NCT03922464","phase":"PHASE4","title":"Efficacy and Safety of Poly-L-lactic Acid","status":"COMPLETED","sponsor":"Erevna Innovations Inc.","startDate":"2019-04-08","conditions":"Buttock Contouring, Buttock Lifting","enrollment":30},{"nctId":"NCT00447551","phase":"PHASE4","title":"Canadian Aesthetic Experience With Sculptra Therapy","status":"COMPLETED","sponsor":"Bausch Health Americas, Inc.","startDate":"2007-01","conditions":"Skin Aging","enrollment":76},{"nctId":"NCT03487172","phase":"NA","title":"Sculptra Aesthetic for the Treatment of Upper Knee Skin Laxity","status":"COMPLETED","sponsor":"Goldman, Butterwick, Fitzpatrick and Groff","startDate":"2018-04-10","conditions":"Lax Skin, Knee","enrollment":20},{"nctId":"NCT02003833","phase":"PHASE4","title":"Poly-L-lactic Acid for Skin Quality","status":"COMPLETED","sponsor":"Sadick Research Group","startDate":"2013-09","conditions":"Skin Aging","enrollment":40},{"nctId":"NCT01307865","phase":"PHASE4","title":"Volume Restoration of the Aging Midface With Sculptra Aesthetic","status":"COMPLETED","sponsor":"Williams Center Plastic Surgery Specialists","startDate":"2011-01","conditions":"Problem of Aging","enrollment":15}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Sculptra Aesthetic","genericName":"Sculptra Aesthetic","companyName":"Erevna Innovations Inc.","companyId":"erevna-innovations-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Sculptra Aesthetic stimulates collagen production in the skin through a biostimulatory effect, gradually restoring facial volume and improving skin texture. Used for Facial wrinkles and folds (nasolabial folds, marionette lines, chin wrinkles), Loss of facial volume and skin laxity.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":2,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}