{"id":"scopolamine-hbr","safety":{"commonSideEffects":[{"rate":null,"effect":"Dry mouth"},{"rate":null,"effect":"Drowsiness"},{"rate":null,"effect":"Blurred vision"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Urinary retention"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"Scopolamine is a tropane alkaloid that competitively antagonizes muscarinic acetylcholine receptors in the central and peripheral nervous system. By blocking these receptors, it reduces parasympathetic activity, thereby decreasing salivary and gastric secretions and suppressing signals from the vestibular system that trigger nausea and vomiting. This mechanism makes it effective for motion sickness and potentially other conditions involving excessive secretions or vestibular dysfunction.","oneSentence":"Scopolamine HBr is an anticholinergic agent that blocks muscarinic acetylcholine receptors to reduce secretions and motion-induced nausea.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:33:47.636Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Motion sickness prevention"},{"name":"Nausea and vomiting (potentially in phase 3 context)"}]},"trialDetails":[{"nctId":"NCT05548270","phase":"PHASE3","title":"Efficacy and Safety of DPI-386 Nasal Gel for the Prevention of Nausea and Vomiting Associated With Motion","status":"COMPLETED","sponsor":"Repurposed Therapeutics, Inc.","startDate":"2022-08-23","conditions":"Motion Sickness","enrollment":503},{"nctId":"NCT04947423","phase":"PHASE3","title":"Nasal Gel for the Prevention of Nausea and Vomiting Associated With Motion","status":"COMPLETED","sponsor":"Repurposed Therapeutics, Inc.","startDate":"2021-06-14","conditions":"Motion Sickness","enrollment":140},{"nctId":"NCT03874130","phase":"PHASE1","title":"Scopolamine in Healthy Volunteers","status":"UNKNOWN","sponsor":"Repurposed Therapeutics, Inc.","startDate":"2018-08-01","conditions":"Major Depressive Disorder (MDD)","enrollment":130},{"nctId":"NCT04272255","phase":"PHASE3","title":"Nasal Gel Under Military Operational Conditions for the Prevention of Nausea Associated With Motion Sickness","status":"UNKNOWN","sponsor":"Repurposed Therapeutics, Inc.","startDate":"2019-04-22","conditions":"Motion Sickness","enrollment":300},{"nctId":"NCT04184115","phase":"PHASE3","title":"Nasal Gel for the Prevention and Treatment of Nausea Associated With Motion Sickness","status":"COMPLETED","sponsor":"Repurposed Therapeutics, Inc.","startDate":"2019-06-09","conditions":"Motion Sickness","enrollment":102}],"_emaApprovals":[],"_faersSignals":[{"count":4,"reaction":"INSOMNIA"},{"count":3,"reaction":"BLOOD PRESSURE INCREASED"},{"count":3,"reaction":"FEBRILE NEUTROPENIA"},{"count":3,"reaction":"MEMORY IMPAIRMENT"},{"count":3,"reaction":"NAUSEA"},{"count":3,"reaction":"PRE-EXISTING CONDITION IMPROVED"},{"count":3,"reaction":"THERAPEUTIC RESPONSE UNEXPECTED"},{"count":3,"reaction":"URINARY TRACT INFECTION"},{"count":3,"reaction":"WEIGHT DECREASED"},{"count":3,"reaction":"WEIGHT INCREASED"}],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"scopolamine HBr","genericName":"scopolamine HBr","companyName":"Repurposed Therapeutics, Inc.","companyId":"repurposed-therapeutics-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Scopolamine HBr is an anticholinergic agent that blocks muscarinic acetylcholine receptors to reduce secretions and motion-induced nausea. Used for Motion sickness prevention, Nausea and vomiting (potentially in phase 3 context).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}