{"id":"sci-b-vac-lot-a","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site pain or erythema"},{"rate":null,"effect":"Fatigue"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Myalgia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Sci-B-Vac uses recombinant DNA technology to express hepatitis B surface antigen (HBsAg) in yeast, similar to other HBV vaccines, but with formulation and antigen design optimizations intended to enhance immune response. The vaccine stimulates both humoral and cellular immunity to prevent hepatitis B infection and its sequelae.","oneSentence":"Sci-B-Vac is a recombinant hepatitis B vaccine designed to provide improved immunogenicity and broader protection against hepatitis B virus variants.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:33:46.215Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of hepatitis B infection in adults and adolescents"}]},"trialDetails":[{"nctId":"NCT04531098","phase":"PHASE3","title":"A Bridging Study: Comparing Two Lots of Sci-B-Vac™ and Engerix-B in Healthy Adults","status":"COMPLETED","sponsor":"VBI Vaccines Inc.","startDate":"2006-03-02","conditions":"Hepatitis B","enrollment":402},{"nctId":"NCT03408730","phase":"PHASE3","title":"Lot-to-lot Consistency of Sci-B-Vac™ in Adults","status":"COMPLETED","sponsor":"VBI Vaccines Inc.","startDate":"2017-12-14","conditions":"Hepatitis B Vaccines","enrollment":2838}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Sci-B-Vac","3-antigen HepB Vaccine","Bio-Hep-B"],"phase":"phase_3","status":"active","brandName":"Sci-B-Vac-Lot A","genericName":"Sci-B-Vac-Lot A","companyName":"VBI Vaccines Inc.","companyId":"vbi-vaccines-inc","modality":"Biologic","firstApprovalDate":"","aiSummary":"Sci-B-Vac-Lot A is a vaccine used to study and prevent Hepatitis B. It is being compared to Engerix-B in a clinical trial to assess its safety and efficacy in healthy adults.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}