{"id":"sch-39641","safety":{"commonSideEffects":[{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Dyspepsia"},{"rate":null,"effect":"Elevated liver enzymes"}]},"_chembl":{"chemblId":"CHEMBL513136","moleculeType":"Small molecule","molecularWeight":"397.56"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The drug works by antagonizing cysteinyl leukotriene receptors (CysLT1 and/or CysLT2), which are key mediators of inflammation and bronchoconstriction in allergic and asthmatic conditions. By blocking these receptors, SCH 39641 reduces the recruitment and activation of inflammatory cells, decreasing airway inflammation and improving airflow obstruction.","oneSentence":"SCH 39641 is a leukotriene receptor antagonist that blocks cysteinyl leukotriene receptors to reduce inflammatory responses.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:33:37.590Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Asthma"},{"name":"Allergic rhinitis"}]},"trialDetails":[{"nctId":"NCT01469182","phase":"PHASE3","title":"A Study of Ragweed (Ambrosia Artemisiifolia) Allergy Immunotherapy Tablet in Adults With Ragweed Allergies (P05751)","status":"COMPLETED","sponsor":"ALK-Abelló A/S","startDate":"2011-11","conditions":"Allergy","enrollment":914},{"nctId":"NCT00978029","phase":"PHASE2","title":"Safety Study of Ragweed Allergy Immunotherapy Tablet in Subjects 50 Years of Age and Older (Study P06081)","status":"COMPLETED","sponsor":"ALK-Abelló A/S","startDate":"2009-11","conditions":"Rhinoconjunctivitis, Rhinitis, Conjunctivitis","enrollment":203},{"nctId":"NCT00783198","phase":"PHASE2, PHASE3","title":"Efficacy and Long-Term Safety of Ragweed (Ambrosia Artemisiifolia) Sublingual Tablet in Adults With a History of Ragweed-Induced Rhinoconjunctivitis With or Without Asthma (Study P05233)(COMPLETED)","status":"COMPLETED","sponsor":"ALK-Abelló A/S","startDate":"2009-09","conditions":"Rhinitis; Allergic, With Asthma, Conjunctivitis","enrollment":565},{"nctId":"NCT00770315","phase":"PHASE2, PHASE3","title":"Efficacy and Long-Term Safety of Ragweed (Ambrosia Artemisiifolia) Sublingual Tablet (SCH 39641) in Adults With a History of Ragweed-Induced Rhinoconjunctivitis With or Without Asthma (Study P05234)","status":"COMPLETED","sponsor":"ALK-Abelló A/S","startDate":"2009-09","conditions":"Rhinitis, Allergic, Conjunctivitis","enrollment":784}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["MK-3641"],"phase":"phase_3","status":"active","brandName":"SCH 39641","genericName":"SCH 39641","companyName":"ALK-Abelló A/S","companyId":"alk-abell-a-s","modality":"Biologic","firstApprovalDate":"","aiSummary":"SCH 39641 is a leukotriene receptor antagonist that blocks cysteinyl leukotriene receptors to reduce inflammatory responses. Used for Asthma, Allergic rhinitis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}