{"id":"scalp-block-with-0-5-plain-marcaine","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site pain or discomfort"},{"rate":null,"effect":"Transient paresthesia"},{"rate":null,"effect":"Systemic toxicity (if absorbed in high concentrations)"},{"rate":null,"effect":"Allergic reaction (rare with amide local anesthetics)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Bupivacaine is a long-acting amide local anesthetic that reversibly inhibits sodium influx through voltage-gated sodium channels in nerve cell membranes. This prevents depolarization and conduction of nerve impulses, resulting in local anesthesia. When administered as a scalp block, it anesthetizes the sensory nerves of the scalp to prevent pain during surgical procedures.","oneSentence":"Bupivacaine blocks sodium channels in nerve fibers, preventing the initiation and propagation of action potentials to produce local anesthesia.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:37:32.689Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Local anesthesia for scalp procedures and surgery"}]},"trialDetails":[{"nctId":"NCT07496632","phase":"NA","title":"Effect of Scalp Block on Intraoperative Hemodynamics and Postoperative Pain in Craniotomy Patients\"","status":"NOT_YET_RECRUITING","sponsor":"Bangladesh Medical University","startDate":"2026-04","conditions":"Scalp Block","enrollment":72},{"nctId":"NCT02057367","phase":"PHASE4","title":"Scalp Nerve Block and Opioid Consumption in Brain Surgery","status":"COMPLETED","sponsor":"Chiang Mai University","startDate":"2013-03","conditions":"Brain Tumour","enrollment":100}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Code 1"],"phase":"marketed","status":"active","brandName":"Scalp block with 0.5% plain Marcaine","genericName":"Scalp block with 0.5% plain Marcaine","companyName":"Chiang Mai University","companyId":"chiang-mai-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Bupivacaine blocks sodium channels in nerve fibers, preventing the initiation and propagation of action potentials to produce local anesthesia. Used for Local anesthesia for scalp procedures and surgery.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}