{"id":"saw-palmetto-berry-extract","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Sexual dysfunction"},{"rate":null,"effect":"Mild abdominal discomfort"}]},"_chembl":null,"_dailymed":{"setId":"996dbd3c-c2e6-43d2-86de-051ee674e96f","title":"TEMPO AROUSAL (HORNY GOAT WEED EXTRACT, MACA ROOT POWDER, TONGKAT ALI ROOT POWDER, SAW PALMETTO BERRY POWDER, TRIBULUS TERRESTRIS EXTRACT, POLYPODIUM VULGARE POWDER, MUIRA PUAMA ROOT POWDER) CAPSULE [PRONOVA CORPORATION]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The extract contains fatty acids and phytosterols that inhibit the conversion of testosterone to dihydrotestosterone (DHT) via 5-alpha reductase inhibition, and may also have anti-inflammatory and antiproliferative effects on prostate tissue. This reduces prostate enlargement and associated lower urinary tract symptoms in men with benign prostatic hyperplasia (BPH).","oneSentence":"Saw palmetto berry extract inhibits 5-alpha reductase and blocks androgen receptor signaling to reduce prostate inflammation and improve urinary symptoms associated with benign prostatic hyperplasia.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:07:01.092Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Benign prostatic hyperplasia (BPH) with lower urinary tract symptoms"}]},"trialDetails":[{"nctId":"NCT06174441","phase":"NA","title":"The Effect of 24-week Dietary Intake of Food Supplements on Hair","status":"COMPLETED","sponsor":"VIST - Faculty of Applied Sciences","startDate":"2024-01-08","conditions":"Hair Thinning, Hair Loss","enrollment":89},{"nctId":"NCT00603304","phase":"PHASE3","title":"Complementary and Alternative Medicine for Urological Symptoms(CAMUS)","status":"COMPLETED","sponsor":"University of Alabama at Birmingham","startDate":"2008-02","conditions":"Urological","enrollment":369},{"nctId":"NCT01021267","phase":"PHASE4","title":"Clinical Study to Assess the Influence of a Saw Palmetto Preparation in Patients With Benign Prostatic Hyperplasia (BPH) and Sexual Dysfunctions","status":"UNKNOWN","sponsor":"A. Vogel AG","startDate":"2009-11","conditions":"Sexual Dysfunctions in Men With Benign Prostatic Hyperplasia","enrollment":50}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":3,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Prostasan"],"phase":"marketed","status":"active","brandName":"Saw palmetto berry extract","genericName":"Saw palmetto berry extract","companyName":"A. Vogel AG","companyId":"a-vogel-ag","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Saw palmetto berry extract inhibits 5-alpha reductase and blocks androgen receptor signaling to reduce prostate inflammation and improve urinary symptoms associated with benign prostatic hyperplasia. Used for Benign prostatic hyperplasia (BPH) with lower urinary tract symptoms.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}