{"id":"sanvar-vapreotide","safety":{"commonSideEffects":[{"rate":null,"effect":"Abdominal pain"},{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Injection site reactions"},{"rate":null,"effect":"Hyperglycemia"}]},"_chembl":{"chemblId":"CHEMBL6067976","moleculeType":"Protein","molecularWeight":"1191.45"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Vapreotide mimics somatostatin, a natural inhibitory hormone, by binding to somatostatin receptors (particularly SSTR2 and SSTR5) on neuroendocrine tumor cells and normal endocrine tissues. This binding suppresses the release of growth hormone, insulin, glucagon, and other hormones, thereby reducing hormone-related symptoms and potentially slowing tumor growth. It is used primarily in the management of carcinoid syndrome and other neuroendocrine tumor-related complications.","oneSentence":"Vapreotide is a somatostatin analog that binds to somatostatin receptors to inhibit the secretion of various hormones and reduce symptoms in neuroendocrine tumors.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:33:23.980Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Carcinoid syndrome associated with neuroendocrine tumors"},{"name":"Acromegaly (in selected cases)"}]},"trialDetails":[{"nctId":"NCT00331188","phase":"PHASE3","title":"Use of Sanvar® With Endoscopic Treatment for the Control of Acute Variceal Bleeding","status":"COMPLETED","sponsor":"Debiovision","startDate":"2006-05","conditions":"Esophageal Varices, Portal Hypertension, Gastric Varices","enrollment":70}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Sanvar® (vapreotide)","genericName":"Sanvar® (vapreotide)","companyName":"Debiovision","companyId":"debiovision","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Sanvar (vapreotide) is a protein-based medication used to treat conditions related to portal hypertension, including esophageal varices, gastric varices, and esophageal bleeding. It is typically used in conjunction with endoscopic treatment for the control of acute variceal bleeding due to portal hypertension.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}