{"id":"saline-vials-or-bags","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypersensitivity reactions"},{"rate":null,"effect":"Infection at the injection site"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Saline solution is isotonic, meaning it has the same concentration of solutes as human blood. This allows it to be administered intravenously without causing hemolysis or other adverse effects. Saline solution can be used to treat dehydration, shock, and other conditions where fluid replacement is necessary.","oneSentence":"Saline solution is used to replenish fluids and electrolytes in the body.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:54:17.954Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Treatment of dehydration"},{"name":"Prevention and treatment of shock"}]},"trialDetails":[{"nctId":"NCT05324358","phase":"PHASE3","title":"Ketorolac Applied by Continuous IV Infusion for Treatment of Moderately Severe Postoperative Pain Following Bunionectomy","status":"COMPLETED","sponsor":"Neumentum, Inc.","startDate":"2022-12-14","conditions":"Pain, Postoperative","enrollment":341},{"nctId":"NCT06389474","phase":"PHASE3","title":"Efficacy of INM004 in Children With STEC-HUS","status":"RECRUITING","sponsor":"Inmunova S.A.","startDate":"2024-10-05","conditions":"Hemolytic-Uremic Syndrome","enrollment":220},{"nctId":"NCT05002998","phase":"PHASE4","title":"TEPEZZA® (Teprotumumab-trbw) Post-Marketing Requirement Study","status":"COMPLETED","sponsor":"Amgen","startDate":"2021-09-16","conditions":"Thyroid Eye Disease","enrollment":313},{"nctId":"NCT02367040","phase":"PHASE3","title":"Copanlisib and Rituximab in Relapsed Indolent B-cell Non-Hodgkin's Lymphoma (iNHL)","status":"COMPLETED","sponsor":"Bayer","startDate":"2015-08-03","conditions":"Lymphoma,Non-Hodgkin","enrollment":458},{"nctId":"NCT06251375","phase":"PHASE4","title":"Early Sedation With Dexmedetomidine vs. Placebo in Older Ventilated Critically Ill Patients","status":"NOT_YET_RECRUITING","sponsor":"St. Joseph's Healthcare Hamilton","startDate":"2025-09-07","conditions":"Respiratory Insufficiency","enrollment":300},{"nctId":"NCT02813655","phase":"PHASE2","title":"Evaluation of the Effectiveness and Tolerance of Tetracosactide Synacthen® in the Treatment of Post Dural Puncture Headaches 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Progression of Intraluminal Pulmonary Vein Stenosis","status":"COMPLETED","sponsor":"Boston Children's Hospital","startDate":"2008-10","conditions":"Pulmonary Veno Occlusive Disease","enrollment":50},{"nctId":"NCT02277197","phase":"PHASE1","title":"Ficlatuzumab and Cetuximab in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma (HNSCC)","status":"COMPLETED","sponsor":"James J Lee","startDate":"2015-08","conditions":"Carcinoma, Squamous Cell of Head and Neck, Squamous Cell Carcinoma of the Head and Neck, Squamous Cell Carcinoma, Head And Neck","enrollment":14},{"nctId":"NCT03335124","phase":"PHASE4","title":"The Effect of Vitamin C, Thiamine and Hydrocortisone on Clinical Course and Outcome in Patients With Severe Sepsis and Septic Shock","status":"TERMINATED","sponsor":"University Medical Centre Ljubljana","startDate":"2017-09-26","conditions":"Sepsis, Septic Shock, Critical Illness","enrollment":5},{"nctId":"NCT01448109","phase":"PHASE4","title":"ADjunctive coRticosteroid trEatment iN criticAlly ilL Patients With Septic Shock","status":"COMPLETED","sponsor":"The George Institute","startDate":"2012-06-13","conditions":"Septic Shock","enrollment":3800},{"nctId":"NCT02277184","phase":"PHASE1","title":"Ficlatuzumab, Cisplatin and IMRT in Locally Advanced Head and Neck Squamous Cell Carcinoma","status":"TERMINATED","sponsor":"Julie E. Bauman, MD, MPH","startDate":"2015-09","conditions":"Carcinoma, Squamous Cell of Head and Neck","enrollment":1},{"nctId":"NCT01008527","phase":"PHASE1","title":"Phase I Oncovir Poly IC:LC and NY-ESO-1/gp100","status":"COMPLETED","sponsor":"H. Lee Moffitt Cancer Center and Research Institute","startDate":"2009-10","conditions":"Melanoma","enrollment":22},{"nctId":"NCT00846287","phase":"NA","title":"Assessment of Arformoterol for Chronic Obstructive Pulmonary Disease (COPD) Using Hyperpolarized 3He MRI","status":"COMPLETED","sponsor":"University of Massachusetts, Worcester","startDate":"2008-11","conditions":"Chronic Obstructive Pulmonary Disease","enrollment":16}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":12020,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Saline vials or bags","genericName":"Saline vials or bags","companyName":"GlaxoSmithKline","companyId":"gsk","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Saline vials or bags are used as a placebo in clinical trials, such as the Sedation Practice in Intensive Care Evaluation (SPICE IV) study, which compares dexmedetomidine to a placebo in older ventilated critically ill patients. Saline vials or bags are also known as Potassic Saline [Injection] or Lactated Saline, but their modality is unknown.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}