{"id":"saline-ketamine","safety":{"commonSideEffects":[{"rate":null,"effect":"Dissociation / out-of-body experiences"},{"rate":null,"effect":"Emergence reactions (hallucinations, delirium)"},{"rate":null,"effect":"Increased heart rate and blood pressure"},{"rate":null,"effect":"Nausea and vomiting"},{"rate":null,"effect":"Dizziness"}]},"_chembl":{"chemblId":"CHEMBL742","moleculeType":"Small molecule","molecularWeight":"237.73"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Ketamine is a non-competitive antagonist at the N-methyl-D-aspartate (NMDA) receptor, a subtype of glutamate receptor. This blockade interrupts pain signal transmission and produces dissociative anesthesia characterized by analgesia, amnesia, and preserved airway reflexes. The saline vehicle is a physiologic carrier for intravenous administration.","oneSentence":"Ketamine blocks NMDA glutamate receptors in the central nervous system, producing rapid-onset dissociative anesthesia and analgesia when administered intravenously in saline solution.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:06:35.259Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Induction and maintenance of general anesthesia"},{"name":"Acute pain management and analgesia"},{"name":"Sedation in intensive care settings"}]},"trialDetails":[{"nctId":"NCT04751175","phase":"PHASE4","title":"Management of Pain in Lumbar Arthrodesis","status":"COMPLETED","sponsor":"Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta","startDate":"2013-07-04","conditions":"Pain, Postoperative","enrollment":128},{"nctId":"NCT03336398","phase":"PHASE2","title":"Investigation of the NMDA Antagonist Ketamine as a Treatment for 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