{"id":"saline-infusion","safety":{"commonSideEffects":[{"rate":null,"effect":"Hyperchloremic acidosis"},{"rate":null,"effect":"Fluid overload / pulmonary edema"},{"rate":null,"effect":"Hypokalemia"},{"rate":null,"effect":"Phlebitis at infusion site"}]},"_chembl":{"chemblId":"CHEMBL2108783","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Saline infusion is a basic supportive therapy that provides isotonic fluid containing 0.9% sodium chloride to restore intravascular volume, maintain hydration, and preserve electrolyte homeostasis. It is used across multiple clinical settings to prevent or treat dehydration, support hemodynamic stability, and serve as a vehicle for other medications.","oneSentence":"Saline infusion replaces or maintains fluid and electrolyte balance by delivering a sterile sodium chloride solution intravenously.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:06:35.276Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Fluid and electrolyte replacement in dehydration"},{"name":"Perioperative fluid management"},{"name":"Maintenance of vascular access and hemodynamic support"}]},"trialDetails":[{"nctId":"NCT07497009","phase":"NA","title":"Effect of Lidocaine Infusion Versus Dexmedemidine Infusion on the Neurocognitive Function of Elderly Patients Undergoing Endoscopic Retrograde Cholangiopancreatography(ERCP): a Randomized, Controlled Trial.","status":"COMPLETED","sponsor":"Benha University","startDate":"2024-12-23","conditions":"Neurocognitive Function of Elderly Patients Post Operation","enrollment":30},{"nctId":"NCT05462730","phase":"PHASE2","title":"Pulse Glucocorticoid Therapy in Patients With ST-Segment Elevation Myocardial Infarction","status":"COMPLETED","sponsor":"Thomas Engstrom","startDate":"2022-11-14","conditions":"ST Elevation Myocardial Infarction, Inflammatory Response, Myocardial Reperfusion Injury","enrollment":530},{"nctId":"NCT04847063","phase":"PHASE1","title":"Individual Response to Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Treatment of Peritoneal Carcinomatosis From Peritoneal Mesothelioma or Atypical Mesothelial Proliferation or From Ovarian, Colorectal, or Appendiceal Histologies","status":"RECRUITING","sponsor":"National Cancer Institute (NCI)","startDate":"2021-10-19","conditions":"Peritoneal Mesothelioma, Peritoneal Carcinomatosis, Ovarian Cancer","enrollment":60},{"nctId":"NCT06128629","phase":"PHASE3","title":"MAGNITUDE: A Phase 3 Study of NTLA-2001 in Participants With Transthyretin Amyloidosis With Cardiomyopathy (ATTR-CM)","status":"RECRUITING","sponsor":"Intellia Therapeutics","startDate":"2023-12-13","conditions":"Transthyretin Amyloidosis (ATTR) With Cardiomyopathy","enrollment":1200},{"nctId":"NCT03844061","phase":"PHASE2","title":"Belimumab and Rituximab Combination Therapy for the Treatment of Diffuse Cutaneous Systemic Sclerosis","status":"RECRUITING","sponsor":"Hospital for Special Surgery, New York","startDate":"2019-07-29","conditions":"Systemic Sclerosis","enrollment":30},{"nctId":"NCT01224704","phase":"NA","title":"Water Deprivation Protocol","status":"COMPLETED","sponsor":"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","startDate":"2010-10-19","conditions":"Obesity","enrollment":75},{"nctId":"NCT07497542","phase":"PHASE3","title":"Normal Saline Infusion After Intravenous Thrombolysis in Stroke","status":"NOT_YET_RECRUITING","sponsor":"Tianjin Medical University General Hospital","startDate":"2026-04","conditions":"Brain Infarction","enrollment":752},{"nctId":"NCT04751175","phase":"PHASE4","title":"Management of Pain in Lumbar Arthrodesis","status":"COMPLETED","sponsor":"Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta","startDate":"2013-07-04","conditions":"Pain, Postoperative","enrollment":128},{"nctId":"NCT07273071","phase":"PHASE4","title":"Individualized Multiplex Pathophysiological Treatment of Severe Acute Infections: N-Acetylcysteine","status":"NOT_YET_RECRUITING","sponsor":"Theis S. Itenov","startDate":"2026-07","conditions":"Sepsis, Acute Infection, Severe Infection","enrollment":360},{"nctId":"NCT03540368","phase":"NA","title":"Tranexamic Acid for The Treatment of Gastrointestinal Bleeding","status":"COMPLETED","sponsor":"Indonesia University","startDate":"2018-07-01","conditions":"Gastrointestinal Bleeding","enrollment":48},{"nctId":"NCT05139316","phase":"PHASE3","title":"A Study of Adeno-Associated Virus Serotype 8-Mediated Gene Transfer of Glucose-6-Phosphatase in Patients With Glycogen Storage Disease Type Ia (GSDIa)","status":"COMPLETED","sponsor":"Ultragenyx Pharmaceutical Inc","startDate":"2021-11-08","conditions":"Glycogen Storage Disease Type IA","enrollment":49},{"nctId":"NCT07491991","phase":"PHASE4","title":"Effects of Different Drugs for Glottic Atomization on Postoperative Sore Throat After Thyroid Surgery","status":"COMPLETED","sponsor":"Qianfoshan Hospital","startDate":"2025-03-02","conditions":"Postoperative Pain, NEBULIZATION, Thyroid Surgery","enrollment":96},{"nctId":"NCT05072314","phase":"PHASE3","title":"Long-term Outcomes of Lidocaine Infusions for Post-Operative Pain (LOLIPOP) Trial","status":"RECRUITING","sponsor":"Monash University","startDate":"2022-07-27","conditions":"Breast Cancer, Breast Cancer Female, Breast Conserving Surgery","enrollment":4300},{"nctId":"NCT05321121","phase":"PHASE4","title":"Dexmedotomidine for Acute Pain Control in Patients With Multiple Rib FracturesRandomized Controlled Trial","status":"COMPLETED","sponsor":"University of California, Irvine","startDate":"2021-11-12","conditions":"Rib Fractures, Pain, Acute","enrollment":41},{"nctId":"NCT07493577","phase":"PHASE1, PHASE2","title":"Induced Suppression of Platelet Activity in Aneurysmal Subarachnoid Hemorrhage Management-2 (iSPASM-2)","status":"NOT_YET_RECRUITING","sponsor":"Dr David Hasan, M.D.","startDate":"2026-07-23","conditions":"Aneurysmal Subarachnoid Hemorrhage","enrollment":82},{"nctId":"NCT01453088","phase":"PHASE2","title":"Auto Transplant High Dose Melphalan vs High Dose Melphalan+Bortezomib in Pts With Multiple Myeloma Age 65 Years or Older","status":"TERMINATED","sponsor":"Hackensack Meridian Health","startDate":"2010-06-24","conditions":"Multiple Myeloma","enrollment":63},{"nctId":"NCT06337838","phase":"PHASE3","title":"Bleeding Reduction in Acute and Chronic Kidney Patients Having Surgery (BRACKETS) Pilot Trial","status":"RECRUITING","sponsor":"Hamilton Health Sciences Corporation","startDate":"2025-06-09","conditions":"Chronic Kidney Diseases, Acute Kidney Injury, Bleeding","enrollment":100},{"nctId":"NCT06466135","phase":"PHASE2","title":"Study of WAL0921 in Patients With Glomerular Kidney Diseases","status":"RECRUITING","sponsor":"Walden Biosciences","startDate":"2024-07-02","conditions":"Diabetic Nephropathies, Primary Focal Segmental Glomerulosclerosis, Minimal Change Disease","enrollment":96},{"nctId":"NCT07490808","phase":"NA","title":"Peri-procedural Hydration to Prevent Acute Kidney Injury After Pulsed Field Ablation for Atrial Fibrillation","status":"NOT_YET_RECRUITING","sponsor":"Beijing Anzhen Hospital","startDate":"2026-03","conditions":"Atrial Fibrillation (AF), Acute Kidney Injury","enrollment":290},{"nctId":"NCT07362446","phase":"PHASE2","title":"Prevention of Reperfusion Injury Outcomes Through Effective Cardioprotection Targeting Myocardial Infarction","status":"NOT_YET_RECRUITING","sponsor":"Nyrada Pty Ltd","startDate":"2026-04-16","conditions":"Myocardial Infarction, Reperfusion Injury, AMI","enrollment":300},{"nctId":"NCT02511028","phase":"PHASE1","title":"In Vivo Characterization of Inflammation With Ferumoxytol, an Ultrasmall Superparamagnetic Iron Oxide Nanoparticle, on 7 Tesla Magnetic Resonance Imaging","status":"COMPLETED","sponsor":"National Institute of Neurological Disorders and Stroke (NINDS)","startDate":"2015-11-27","conditions":"Multiple Sclerosis","enrollment":14},{"nctId":"NCT06094816","phase":"PHASE4","title":"Forebrain Electroneutral Transporters in Salt-sensitive Hypertension: an MRI Study","status":"RECRUITING","sponsor":"University of Delaware","startDate":"2024-03-05","conditions":"Salt-Sensitivity of Blood Pressure","enrollment":120},{"nctId":"NCT06480201","phase":"PHASE1","title":"Gamma Oscillations as a Prognostic Marker for Ketamine Therapy in Treatment Resistant Depression","status":"SUSPENDED","sponsor":"Texas A&M University","startDate":"2024-01-01","conditions":"Healthy, Major Depressive Disorder, Treatment Resistant Depression","enrollment":100},{"nctId":"NCT07480889","phase":"PHASE3","title":"Effect of Adding a Low-Dose Epinephrine Bolus Prior to Infusion on Maternal Hemodynamic Stability During Cesarean Section","status":"RECRUITING","sponsor":"Cairo University","startDate":"2026-03-18","conditions":"Hemodynamic (MAP) Stability","enrollment":100},{"nctId":"NCT05669846","phase":"PHASE2","title":"Study of Healthy Donor FMT (hdFMT) and Pembrolizumab in Relapsed/Refractory (R/R) PD-L1 Positive NSCLC","status":"RECRUITING","sponsor":"Diwakar Davar","startDate":"2025-01-08","conditions":"Non Small Cell Lung Cancer","enrollment":26},{"nctId":"NCT07488832","phase":"NA","title":"Intravenous Lidocaine Infusion in Lumbar Fusion Surgery","status":"NOT_YET_RECRUITING","sponsor":"Ankara City Hospital Bilkent","startDate":"2026-03-20","conditions":"Lumbar Fusion Surgery","enrollment":110},{"nctId":"NCT05184764","phase":"PHASE1, PHASE2","title":"Study Evaluating Safety, Tolerability, and Efficacy of Intravenous AP-SA02 in Subjects With S. Aureus Bacteremia","status":"COMPLETED","sponsor":"Armata Pharmaceuticals, Inc.","startDate":"2022-04-26","conditions":"Bacteremia, Staphylococcus Aureus, Staphylococcus Aureus Bacteremia","enrollment":56},{"nctId":"NCT05996835","phase":"PHASE2","title":"Phase 2b Study to Investigate the Safety and Efficacy of TIN816 in Sepsis-associated Acute Kidney Injury (CLEAR-AKI)","status":"ACTIVE_NOT_RECRUITING","sponsor":"Novartis Pharmaceuticals","startDate":"2024-01-18","conditions":"Acute Kidney Injury Due to Sepsis","enrollment":320},{"nctId":"NCT07224711","phase":"PHASE4","title":"The Impact of Perioperative Lidocaine Infusions on Enhanced Recovery After Non-Cardiac Surgery","status":"NOT_YET_RECRUITING","sponsor":"Vanderbilt University Medical Center","startDate":"2026-07-01","conditions":"Pain, Post Operative Analgesia, Opioid Consumption, Postoperative","enrollment":2290},{"nctId":"NCT07466108","phase":"NA","title":"Hemodynamic Effects of Intravenous Paracetamol in Patients Undergoing Emergency Laparotomy","status":"RECRUITING","sponsor":"Cairo University","startDate":"2026-03-18","conditions":"Paracetamol, Hypotension Drug-Induced, Emergency Surgery","enrollment":90},{"nctId":"NCT04763343","phase":"PHASE3","title":"Ketamine Treatment of Youth Suicide Attempters","status":"RECRUITING","sponsor":"Tatiana Falcone, MD","startDate":"2022-06-27","conditions":"Suicide, Attempted","enrollment":60},{"nctId":"NCT04901169","phase":"PHASE2, PHASE3","title":"Angiotensin II in Liver Transplantation","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of California, San Francisco","startDate":"2022-06-28","conditions":"Liver Transplant; Complications, Vasoplegia","enrollment":50},{"nctId":"NCT06229483","phase":"PHASE3","title":"The Effects of Intraoperative Tranexamic Acid on Perioperative Bleeding In Craniotomies","status":"RECRUITING","sponsor":"Stephen Lownie","startDate":"2024-04-03","conditions":"Brain Tumor, Bleeding","enrollment":102},{"nctId":"NCT07048314","phase":"PHASE1, PHASE2","title":"Stem Cells for Erectile Dysfunction Post RALP","status":"NOT_YET_RECRUITING","sponsor":"The Methodist Hospital Research Institute","startDate":"2026-03-10","conditions":"Erectile Dysfunction, Prostate Cancer","enrollment":40},{"nctId":"NCT07481539","phase":"PHASE2","title":"Subcutaneous Piperacillin/Tazobactam Compared With Intravenous Treatment","status":"RECRUITING","sponsor":"Azienda Sanitaria Universitaria Friuli Centrale","startDate":"2026-03-24","conditions":"Bacteria Infection, Piperacillin, Tazobactam Drug Combination","enrollment":240},{"nctId":"NCT07483801","phase":"PHASE4","title":"DECODE - Haemodynamic Effects Of Semaglutide and Tirzepatide - a Series of Pilot Studies","status":"NOT_YET_RECRUITING","sponsor":"Cambridge University Hospitals NHS Foundation Trust","startDate":"2026-03","conditions":"Cardiovascular Diseases","enrollment":112},{"nctId":"NCT07462819","phase":"PHASE1","title":"A Study to Evaluate the Safety and Tolerability of Intravenous Stemis™ in Elderly Subjects With Mild to Moderate Frailty Syndrome","status":"NOT_YET_RECRUITING","sponsor":"Ji Yan Biomedical Co., Ltd.","startDate":"2026-04","conditions":"Frailty Syndrome","enrollment":12},{"nctId":"NCT07483346","phase":"PHASE1","title":"IASO-782 in Systemic Lupus Erythematosus","status":"NOT_YET_RECRUITING","sponsor":"Shanghai IASO Biotechnology Co., Ltd","startDate":"2026-04-30","conditions":"SLE - Systemic Lupus Erythematosus","enrollment":20},{"nctId":"NCT04899908","phase":"PHASE2","title":"Stereotactic Brain-directed Radiation With or Without Aguix Gadolinium-Based Nanoparticles in Brain Metastases","status":"ACTIVE_NOT_RECRUITING","sponsor":"Brigham and Women's Hospital","startDate":"2021-09-15","conditions":"Brain Cancer, Brain Metastases, Melanoma","enrollment":134},{"nctId":"NCT07482540","phase":"NA","title":"Role of Dexmedatomidine Drug in Prevention of Atrial Fibrillations Post Mitral Valve Surgery","status":"NOT_YET_RECRUITING","sponsor":"Ain Shams University","startDate":"2026-06-01","conditions":"New Onset, Atrial Fibrillation","enrollment":140},{"nctId":"NCT01011920","phase":"PHASE2","title":"Trial for Patients With Newly Diagnosed Primary Central Nervous System (CNS) Lymphoma","status":"COMPLETED","sponsor":"International Extranodal Lymphoma Study Group (IELSG)","startDate":"2009-11","conditions":"Central Nervous System Lymphoma","enrollment":227},{"nctId":"NCT06426823","phase":"NA","title":"The Role of GIP in Postprandial Splanchnic Blood Flow Distribution and Metabolism in Patients With Type 2 Diabetes","status":"COMPLETED","sponsor":"University of Copenhagen","startDate":"2023-11-01","conditions":"Blood Flow","enrollment":10},{"nctId":"NCT06621472","phase":"NA","title":"Retrolaminar Block Versus Subcostal Transversus Abdominis Plane Block in Liver Resection Surgery","status":"RECRUITING","sponsor":"Cairo University","startDate":"2024-10-01","conditions":"Cancer Liver","enrollment":90},{"nctId":"NCT07184801","phase":"PHASE3","title":"Safety and Efficacy of Dexmedetomidate vs. Midazolam for Procedural Sedation During Medical Thoracoscopy","status":"RECRUITING","sponsor":"Post Graduate Institute of Medical Education and Research, Chandigarh","startDate":"2025-10-01","conditions":"Medical Thoracoscopy","enrollment":56},{"nctId":"NCT07479446","phase":"NA","title":"Oliceridine Versus Sufentanil for Postoperative Nausea in Cerebellopontine Angle Surgery","status":"NOT_YET_RECRUITING","sponsor":"Xuanwu Hospital, Beijing","startDate":"2026-03-01","conditions":"PONV, Cerebellopontine Angle Tumor, Microvascular Decompression Surgery","enrollment":174},{"nctId":"NCT06408597","phase":"NA","title":"Mannitol Versus Nitroglycerin for Kidney Injury Prevention in Robotic-assisted Radical Prostatectomy or Cystectomy","status":"ACTIVE_NOT_RECRUITING","sponsor":"Nazmy Edward Seif","startDate":"2024-05-12","conditions":"Prostate Cancer, Bladder Cancer, Surgery","enrollment":90},{"nctId":"NCT06599307","phase":"PHASE2","title":"The Effect of Rituximab on Cognitive and Hand Functions in Secondary Progressive Multiple Sclerosis","status":"RECRUITING","sponsor":"Cairo University","startDate":"2024-08-01","conditions":"Secondary Progressive Multiple Sclerosis (SPMS)","enrollment":46},{"nctId":"NCT03258593","phase":"PHASE1","title":"Durvalumab and Vicineum in Subjects With High-Grade Non-Muscle-Invasive Bladder Cancer Previously Treated With Bacillus Calmette-Guerin (BCG)","status":"COMPLETED","sponsor":"National Cancer Institute (NCI)","startDate":"2018-06-07","conditions":"Urinary Bladder Neoplasms","enrollment":15},{"nctId":"NCT06936410","phase":"PHASE2","title":"Using Lidocaine or Dexmedetomidine to Help Control Blood Pressure Spikes From a Tourniquet During Knee Surgery","status":"COMPLETED","sponsor":"Cairo University","startDate":"2025-03-01","conditions":"Tourniquet Hypertension","enrollment":186},{"nctId":"NCT07315074","phase":"NA","title":"Effect of Esketamine on Postoperative Sleep in Postmenopausal Women","status":"NOT_YET_RECRUITING","sponsor":"Zhuan Zhang","startDate":"2026-03-01","conditions":"Circadian Rhythm, Postoperative Sleep Disturbance","enrollment":164},{"nctId":"NCT04512235","phase":"PHASE3","title":"A Study to Evaluate the Efficacy and Safety of CAEL-101 in Patients With Mayo Stage IIIa AL Amyloidosis (CARES)","status":"ACTIVE_NOT_RECRUITING","sponsor":"Alexion Pharmaceuticals, Inc.","startDate":"2020-11-03","conditions":"AL Amyloidosis","enrollment":281},{"nctId":"NCT04029090","phase":"PHASE1","title":"A Study to Evaluate the Effect of MCI-186 at Therapeutic and Supra-Therapeutic Doses on the QT Interval(QT)/Corrected QT Interval(QTc) Interval in Healthy Subjects","status":"COMPLETED","sponsor":"Tanabe Pharma Corporation","startDate":"2018-09-18","conditions":"Healthy Adult Subjects","enrollment":27},{"nctId":"NCT02114229","phase":"PHASE2","title":"Phase 2 Study of Alisertib Therapy for Rhabdoid Tumors","status":"ACTIVE_NOT_RECRUITING","sponsor":"St. Jude Children's Research Hospital","startDate":"2014-05-14","conditions":"Malignant Rhabdoid Tumor, Atypical Teratoid Rhabdoid Tumor","enrollment":125},{"nctId":"NCT04504825","phase":"PHASE3","title":"A Study to Evaluate the Efficacy and Safety of CAEL-101 in Patients With Mayo Stage IIIb AL Amyloidosis (CARES)","status":"ACTIVE_NOT_RECRUITING","sponsor":"Alexion Pharmaceuticals, Inc.","startDate":"2020-08-25","conditions":"AL Amyloidosis","enrollment":125},{"nctId":"NCT07473128","phase":"PHASE3","title":"Effect of Trilaciclib in the Prevention of Myelosupression in Subjects With Limited-stage Small Cell Lung Cancer","status":"NOT_YET_RECRUITING","sponsor":"Pharmacosmos A/S","startDate":"2026-03-31","conditions":"Limited Stage Small Cell Lung Cancer","enrollment":120},{"nctId":"NCT07466173","phase":"NA","title":"The Importance of Insulin Action in the Brain for the Immune System During Physical Activity-Overweight","status":"NOT_YET_RECRUITING","sponsor":"University of Ulm","startDate":"2026-04","conditions":"Insulin Sensitivity","enrollment":8},{"nctId":"NCT04580563","phase":"NA","title":"Study Assessing Efficacy of Plasmatherapy in Septic Shock-induced Coagulopathy: Feasibility Study","status":"COMPLETED","sponsor":"University Hospital, Strasbourg, France","startDate":"2020-10-22","conditions":"Septic Shock, Coagulopathy, Disseminated Intravascular Coagulation","enrollment":60},{"nctId":"NCT05065424","phase":"PHASE4","title":"Premedication for Less Invasive Surfactant Administration Study (PRELISA)","status":"COMPLETED","sponsor":"University of Texas Southwestern Medical Center","startDate":"2022-04-06","conditions":"Respiratory Distress Syndrome, Newborn","enrollment":58},{"nctId":"NCT05612178","phase":"PHASE1","title":"A Study to Evaluate the Safety and Effects of Repeated Doses of 3BNC117-LS and 10-1074-LS on Persistent Viral Reservoirs in People Living With HIV and on Suppressive Antiretroviral Therapy","status":"ACTIVE_NOT_RECRUITING","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2023-07-26","conditions":"HIV-1","enrollment":105},{"nctId":"NCT04488081","phase":"PHASE2","title":"I-SPY COVID-19 TRIAL: An Adaptive Platform Trial for Critically Ill Patients","status":"ACTIVE_NOT_RECRUITING","sponsor":"QuantumLeap Healthcare Collaborative","startDate":"2020-07-31","conditions":"COVID-19","enrollment":1500},{"nctId":"NCT05958342","phase":"PHASE2","title":"CAlcium and VAsopressin Following Injury Early Resuscitation (CAVALIER) Trial","status":"RECRUITING","sponsor":"Jason Sperry","startDate":"2024-06-30","conditions":"Trauma, Hemorrhage","enrollment":1050},{"nctId":"NCT07387354","phase":"PHASE1, PHASE2","title":"Pacritinib With Aza for Upfront Myelodysplastic Syndrome","status":"NOT_YET_RECRUITING","sponsor":"Thomas Jefferson University","startDate":"2026-05","conditions":"Myelodysplastic Syndromes, MDS, Myelodysplastic Syndrome, Unclassifiable","enrollment":25},{"nctId":"NCT07472270","phase":"PHASE1","title":"Safety Evaluation of MSC-based Therapy for Liver Cihcrosis Treatment","status":"NOT_YET_RECRUITING","sponsor":"Vinmec Research Institute of Stem Cell and Gene Technology","startDate":"2026-03-15","conditions":"Liver Cirrhosis","enrollment":12},{"nctId":"NCT04459117","phase":"PHASE2, PHASE3","title":"Prophylactic Treatment of the Ductus Arteriosus in Preterm Infants by Acetaminophen","status":"COMPLETED","sponsor":"Institut National de la Santé Et de la Recherche Médicale, France","startDate":"2020-10-29","conditions":"Patency of the Ductus Arteriosus, Acetaminophen, Extreme Prematurity","enrollment":804},{"nctId":"NCT07471230","phase":"PHASE2","title":"Evaluation of Neuroinduced Mesenchymal Stem Cells and Mesenchymal Stem Cell-Derived Exosomes in Patients With Parkinsonism","status":"NOT_YET_RECRUITING","sponsor":"Biocells Medical","startDate":"2026-11-23","conditions":"Parkinsonism or Parkinson's Disease Nos, Parkinsonism in Diseases Classified Elsewhere","enrollment":120},{"nctId":"NCT00663611","phase":"PHASE1","title":"Growth Hormone Administration and the Human Immune System","status":"COMPLETED","sponsor":"National Institute on Aging (NIA)","startDate":"2006-10-19","conditions":"Healthy Volunteers","enrollment":66},{"nctId":"NCT02726711","phase":"PHASE1","title":"Reduction in Splanchnic Capacitance Contributes to Sympathetically Dependent Hypertension in Autonomic","status":"ACTIVE_NOT_RECRUITING","sponsor":"Vanderbilt University","startDate":"2016-04","conditions":"Multiple System Atrophy, Orthostatic Hypotension, Supine Hypertension","enrollment":2},{"nctId":"NCT06579690","phase":"PHASE3","title":"Use of Preoperative Sodium Bicarbonate Among Women With Obstructed Labor","status":"RECRUITING","sponsor":"Busitema University","startDate":"2025-05-06","conditions":"Obstructed Labor","enrollment":472},{"nctId":"NCT04838301","phase":"PHASE2","title":"Allopregnanolone Regenerative Therapeutic for Mild Alzheimer's Disease","status":"RECRUITING","sponsor":"University of Arizona","startDate":"2023-08-15","conditions":"Alzheimer Dementia, Late Onset Alzheimer Disease, Neurodegenerative Diseases","enrollment":100},{"nctId":"NCT04468659","phase":"PHASE3","title":"AHEAD 3-45 Study: A Study to Evaluate Efficacy and Safety of Treatment With Lecanemab in Participants With Preclinical Alzheimer's Disease and Elevated Amyloid and Also in Participants With Early Preclinical Alzheimer's Disease and Intermediate Amyloid","status":"ACTIVE_NOT_RECRUITING","sponsor":"Eisai Inc.","startDate":"2020-07-14","conditions":"Preclinical Alzheimer's Disease, Early Preclinical Alzheimer's Disease","enrollment":1400},{"nctId":"NCT06608277","phase":"PHASE2","title":"Ketamine, SGB and Combination Treatment for TBI","status":"RECRUITING","sponsor":"Northwestern University","startDate":"2025-07-02","conditions":"Posttraumatic Headache, Posttraumatic Stress Disorder","enrollment":175},{"nctId":"NCT06685757","phase":"PHASE3","title":"A Study to Learn More About the Effects and Safety of Felzartamab Infusions in Adults With Kidney Transplants Who Have Antibody-Mediated Rejection (AMR)","status":"RECRUITING","sponsor":"Biogen","startDate":"2024-12-03","conditions":"Antibody-mediated Rejection","enrollment":120},{"nctId":"NCT07467733","phase":"PHASE1, PHASE2","title":"Evaluation of the Safety and Preliminary Efficacy of Neuroinduced Mesenchymal Stem Cells and Exosome Therapy in Patients With Spinocerebellar Palsy","status":"NOT_YET_RECRUITING","sponsor":"Biocells Medical","startDate":"2026-06-01","conditions":"Spinocerebellar Ataxia - All Sub-types","enrollment":90},{"nctId":"NCT07212868","phase":"PHASE1","title":"The Role of Glucagon in Glucose Metabolism in Humans With and Without Bariatric Surgery","status":"RECRUITING","sponsor":"The University of Texas Health Science Center at San Antonio","startDate":"2026-02-25","conditions":"Non-Diabetic","enrollment":150},{"nctId":"NCT07436364","phase":"EARLY_PHASE1","title":"Application of Contrast-enhanced Ultrasound in Monitoring Soft Tissue Sarcoma Response to Neoadjuvant Radiotherapy","status":"NOT_YET_RECRUITING","sponsor":"Thomas Jefferson University","startDate":"2026-03","conditions":"Soft Tissue Sarcoma","enrollment":10},{"nctId":"NCT05027269","phase":"PHASE1, PHASE2","title":"Study of AOC 1001 in Adult Myotonic Dystrophy Type 1 (DM1) Patients","status":"COMPLETED","sponsor":"Avidity Biosciences, Inc.","startDate":"2021-10-28","conditions":"DM1, Myotonic Dystrophy 1, Myotonic Dystrophy","enrollment":39},{"nctId":"NCT07464249","phase":"NA","title":"Comparison of the Effectiveness of Different Diuretic Therapies in the Management of Acute Heart Failure","status":"COMPLETED","sponsor":"Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey","startDate":"2024-04-03","conditions":"Acute Decompensated Heart Failure (ADHF)","enrollment":50},{"nctId":"NCT07134712","phase":"PHASE2","title":"Safety and Efficacy of MiSaver (CB Cells) for Acute Myocardial Infarction, Phase II","status":"NOT_YET_RECRUITING","sponsor":"HONYA Medical Co Ltd","startDate":"2026-03-30","conditions":"Acute Myocardial Infarction (AMI)","enrollment":102},{"nctId":"NCT06901531","phase":"PHASE3","title":"A Study of Zolbetuximab Together With Pembrolizumab and Chemotherapy in Adults With Gastric Cancer","status":"RECRUITING","sponsor":"Astellas Pharma Global Development, Inc.","startDate":"2025-05-22","conditions":"Locally Advanced Unresectable Gastroesophageal Junction (GEJ) Adenocarcinoma or Cancer, Locally Advanced Unresectable Gastric Adenocarcinoma or Cancer, Metastatic Gastric Adenocarcinoma or Cancer","enrollment":500},{"nctId":"NCT04895358","phase":"PHASE3","title":"Study of Pembrolizumab (MK-3475) Plus Chemotherapy Versus Placebo Plus Chemotherapy for HR+/HER2- Locally Recurrent Inoperable or Metastatic Breast Cancer (MK-3475-B49/KEYNOTE-B49)","status":"ACTIVE_NOT_RECRUITING","sponsor":"Merck Sharp & Dohme LLC","startDate":"2021-06-18","conditions":"Breast Neoplasms","enrollment":340},{"nctId":"NCT06265051","phase":"PHASE2, PHASE3","title":"Tirofiban After Successful MT Recanalization in AIS","status":"COMPLETED","sponsor":"Xiang Luo","startDate":"2024-04-09","conditions":"Acute Ischemic Stroke, Vessel Occlusion","enrollment":1380},{"nctId":"NCT06655025","phase":"NA","title":"The Effects of Dexmedetomidine on Postoperative Cognitive Function in Open Heart Surgery","status":"COMPLETED","sponsor":"Sohag University","startDate":"2023-10-08","conditions":"Cardiac Surgery, Postoperative Cognitive Dysfunction, Neurologic Manifestations","enrollment":32},{"nctId":"NCT07465198","phase":"PHASE2","title":"Autologous Stem Cell Therapy in Patients With Multiple System Atrophy","status":"NOT_YET_RECRUITING","sponsor":"Biocells Medical","startDate":"2026-09-01","conditions":"MSA - Multiple System Atrophy, MSA","enrollment":50},{"nctId":"NCT06059846","phase":"PHASE3","title":"A Study of Oral Tebipenem Pivoxil Hydrobromide (TBP-PI-HBr) Compared to Intravenous Imipenem-cilastatin in Participants With Complicated Urinary Tract Infection (cUTI) or Acute Pyelonephritis (AP)","status":"COMPLETED","sponsor":"Spero Therapeutics","startDate":"2023-12-21","conditions":"Urinary Tract Infection, Acute Pyelonephritis","enrollment":1690},{"nctId":"NCT06908083","phase":"PHASE1","title":"Immunologic and Virologic Parameters During Analytical Treatment Interruption Following Combination bNAb Therapy During Suppressive ART","status":"ENROLLING_BY_INVITATION","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2025-09-08","conditions":"HIV","enrollment":50},{"nctId":"NCT04862221","phase":"PHASE2","title":"TReatment for ImmUne Mediated PathopHysiology","status":"RECRUITING","sponsor":"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","startDate":"2022-02-09","conditions":"Acute Liver Failure, Fulminant Hepatic Failure, Hepatic Encephalopathy","enrollment":163},{"nctId":"NCT07214974","phase":"EARLY_PHASE1","title":"Mild Cognitive Impairment Community Screening and Early Intervention Via Stem Cell Therapy and Wearable Brain Computer Interface Device.","status":"NOT_YET_RECRUITING","sponsor":"Noah Tech, Corp.","startDate":"2026-09-01","conditions":"Mild Cognitive Impairment (MCI), Early Stages of Cognitive Decline, Alzheimer's Disease Dementia","enrollment":600},{"nctId":"NCT07116343","phase":"PHASE4","title":"Intrapleural Ropivacaine Infusion in Cardiac Surgery","status":"RECRUITING","sponsor":"Saint Petersburg State University, Russia","startDate":"2025-10-22","conditions":"Cardiac Surgery, Coronary Artery Disease, Valvular Diseases","enrollment":116},{"nctId":"NCT07118592","phase":"NA","title":"Genetic Architecture of Natriuretic Peptides and Blood Pressure Response","status":"NOT_YET_RECRUITING","sponsor":"University of Alabama at Birmingham","startDate":"2026-09-01","conditions":"Hypertension (HTN), Cardiometabolic Diseases","enrollment":200},{"nctId":"NCT03142334","phase":"PHASE3","title":"Safety and Efficacy Study of Pembrolizumab (MK-3475) as Monotherapy in the Adjuvant Treatment of Renal Cell Carcinoma Post Nephrectomy (MK-3475-564/KEYNOTE-564)","status":"COMPLETED","sponsor":"Merck Sharp & Dohme LLC","startDate":"2017-06-09","conditions":"Renal Cell Carcinoma","enrollment":994},{"nctId":"NCT04828083","phase":"PHASE4","title":"Systemic Lidocaine Versus Ultrasound-guided Adductor Canal Block for Patients Undergoing Total Knee Arthroplasty","status":"COMPLETED","sponsor":"Rhode Island Hospital","startDate":"2021-03-01","conditions":"Arthroplasty, Replacement, Knee, Total Knee Arthroplasty","enrollment":120},{"nctId":"NCT03221426","phase":"PHASE3","title":"Study of Pembrolizumab (MK-3475) Plus Chemotherapy Versus Placebo Plus Chemotherapy in Participants With Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma (MK-3475-585/KEYNOTE-585)","status":"COMPLETED","sponsor":"Merck Sharp & Dohme LLC","startDate":"2017-10-09","conditions":"Gastric Cancer, Gastroesophageal Junction Cancer","enrollment":1007},{"nctId":"NCT05116189","phase":"PHASE3","title":"Pembrolizumab/Placebo Plus Paclitaxel With or Without Bevacizumab for Platinum-resistant Recurrent Ovarian Cancer (MK-3475-B96/KEYNOTE-B96/ENGOT-ov65).","status":"ACTIVE_NOT_RECRUITING","sponsor":"Merck Sharp & Dohme LLC","startDate":"2021-12-13","conditions":"Ovarian Cancer, Carcinoma, Ovarian Epithelial, Fallopian Tube Neoplasms","enrollment":643},{"nctId":"NCT07451769","phase":"NA","title":"Selective Activation of the Adrenomedullin Receptors in Migraine","status":"NOT_YET_RECRUITING","sponsor":"Danish Headache Center","startDate":"2026-03-10","conditions":"Migraine, Brain Diseases, Central Nervous System Diseases","enrollment":26},{"nctId":"NCT07457008","phase":"PHASE1","title":"Tolerability & Pharmacokinetics of Ginkgolide B Injection: Single- and Multiple-Ascending Doses in Healthy Subjects","status":"COMPLETED","sponsor":"West China Second University Hospital","startDate":"2021-07-01","conditions":"Healthy Volunteers","enrollment":36},{"nctId":"NCT04362527","phase":"PHASE3","title":"Milrinone Infusion for VAsospam Treatment in Subarachnoid hemoRrhage","status":"COMPLETED","sponsor":"University Hospital, Angers","startDate":"2020-08-10","conditions":"Vasospasm","enrollment":370},{"nctId":"NCT07369024","phase":"PHASE2","title":"Sub-dissociative Dose Ketamine in Treatment of Vaso-occlusive Pain Event in Children and Young Adults","status":"RECRUITING","sponsor":"Mohsen Saidinejad","startDate":"2026-04-01","conditions":"Sickle Cell Disease, Vaso-Occlusive Pain Episode in Sickle Cell Disease, Ketamine Infusion","enrollment":120},{"nctId":"NCT06534983","phase":"PHASE2","title":"A Study to Evaluate the Efficacy and Safety of Autogene Cevumeran With Nivolumab Versus Nivolumab Alone in Participants With High-risk Muscle-invasive Urothelial Carcinoma (MIUC)","status":"RECRUITING","sponsor":"Hoffmann-La Roche","startDate":"2024-12-09","conditions":"Muscle-invasive Urothelial Carcinoma","enrollment":362},{"nctId":"NCT07333859","phase":"PHASE4","title":"Effect of IV Lidocaine on Duodenal Peristalsis and Sedation in ERCP","status":"RECRUITING","sponsor":"Ankara City Hospital Bilkent","startDate":"2026-02-11","conditions":"Duodenal Spasm, ERCP, Sedation","enrollment":120},{"nctId":"NCT06028126","phase":"NA","title":"Superficial Parasternal Intercostal Plane Block in Cardiac Surgery Trial","status":"COMPLETED","sponsor":"Unity Health Toronto","startDate":"2023-09-08","conditions":"Post-operative Pain, Post-operative Delirium, Post-cardiac Surgery","enrollment":340}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":5114,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["saline","Saline","Normal saline solution","0.9% sodium chloride solution","normal saline infusion"],"phase":"marketed","status":"active","brandName":"saline infusion","genericName":"saline infusion","companyName":"University Hospital, Linkoeping","companyId":"university-hospital-linkoeping","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Saline infusion replaces or maintains fluid and electrolyte balance by delivering a sterile sodium chloride solution intravenously. Used for Fluid and electrolyte replacement in dehydration, Perioperative fluid management, Maintenance of vascular access and hemodynamic support.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":2,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}