{"id":"salicylic-acid-and-ciclopirox-olamine","safety":{"commonSideEffects":[{"rate":null,"effect":"Local irritation"},{"rate":null,"effect":"Erythema"},{"rate":null,"effect":"Pruritus"},{"rate":null,"effect":"Contact dermatitis"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Salicylic acid is a keratolytic agent that softens and removes dead skin cells, enhancing penetration of the antifungal agent. Ciclopirox olamine is a broad-spectrum antifungal and antibacterial agent that disrupts fungal cell membrane integrity and inhibits fungal enzyme systems. Together, they provide enhanced efficacy against dermatophytes, yeasts, and bacteria in topical skin infections.","oneSentence":"Salicylic acid and ciclopirox olamine work synergistically to treat fungal and bacterial skin infections by keratolytic action and antifungal/antibacterial activity.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:06:39.938Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Fungal skin infections (dermatophytosis, candidiasis)"},{"name":"Onychomycosis (nail fungal infections)"},{"name":"Bacterial skin infections"}]},"trialDetails":[{"nctId":"NCT01139749","phase":"PHASE4","title":"Efficacy and Safety of Low-dose Oral Isotretinoin for Seborrhea","status":"UNKNOWN","sponsor":"Federal University of São Paulo","startDate":"2011-10","conditions":"Seborrhea, Seborrheic Dermatitis, Quality of Life","enrollment":50}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":4,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["anti-seborrheic treatment","anti-dandruff treatment"],"phase":"marketed","status":"active","brandName":"salicylic acid and ciclopirox olamine","genericName":"salicylic acid and ciclopirox olamine","companyName":"Federal University of São Paulo","companyId":"federal-university-of-s-o-paulo","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Salicylic acid and ciclopirox olamine work synergistically to treat fungal and bacterial skin infections by keratolytic action and antifungal/antibacterial activity. Used for Fungal skin infections (dermatophytosis, candidiasis), Onychomycosis (nail fungal infections), Bacterial skin infections.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}