{"id":"saizen-b","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Injection site reaction"},{"rate":"10-20%","effect":"Headache"},{"rate":"5-10%","effect":"Nausea"},{"rate":"5-10%","effect":"Diarrhea"},{"rate":"5-10%","effect":"Fatigue"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"It works by stimulating the production of insulin-like growth factor 1 (IGF-1), which promotes growth and development in children with growth hormone deficiency. Saizen B is administered via injection and is available in a variety of formulations to suit different patient needs.","oneSentence":"Saizen B is a recombinant human growth hormone used to treat growth hormone deficiency.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:52:46.828Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Growth hormone deficiency in children"}]},"trialDetails":[{"nctId":"NCT01298180","phase":"PHASE4","title":"Is There a Sensibility Increased in the Growth Hormone at Child With Prader-Willi Syndrome?","status":"COMPLETED","sponsor":"University Hospital, Toulouse","startDate":"2009-01","conditions":"Prader-Willi Syndrome, Growth Hormone Deficiency","enrollment":111},{"nctId":"NCT00960128","phase":"","title":"Observational Prospective Study on Patients Treated With Norditropin®","status":"COMPLETED","sponsor":"Novo Nordisk A/S","startDate":"2006-04-01","conditions":"Growth Hormone Disorder, Growth Hormone Deficiency in Children, Adult Growth Hormone Deficiency","enrollment":21249},{"nctId":"NCT00787878","phase":"","title":"Long Term Metabolic Safety of Norditropin® Treatment of Small for Gestational Age (SGA) Subjects","status":"COMPLETED","sponsor":"Novo Nordisk A/S","startDate":"2009-02","conditions":"Foetal Growth Problem, Small for Gestational Age","enrollment":153},{"nctId":"NCT00934063","phase":"","title":"An Observational Study Validating a Score That Quantifies the Therapeutic Response to Treatment With Norditropin®","status":"COMPLETED","sponsor":"Novo Nordisk A/S","startDate":"2009-07","conditions":"Growth Hormone Disorder, Adult Growth Hormone Deficiency","enrollment":121},{"nctId":"NCT01034735","phase":"PHASE1","title":"r-hGH Liquid Multidose Versus Freeze-dried Multidose Bioequivalence Trial","status":"COMPLETED","sponsor":"EMD Serono","startDate":"2008-07","conditions":"Growth Failure, Growth Hormone Deficiency","enrollment":30},{"nctId":"NCT01400698","phase":"PHASE3","title":"Saizen in Intra-uterine Growth Retardation","status":"COMPLETED","sponsor":"Merck KGaA, Darmstadt, Germany","startDate":"1998-11","conditions":"Children Born With Serious Intra-uterine Growth Retardation","enrollment":91},{"nctId":"NCT00740012","phase":"NA","title":"Glycemic Rises After Waking Up In Response To An Alarm Clock In Type 1-Diabetic Patients Analysed With Continuous Glucose Monitoring (GlucoDay®)","status":"COMPLETED","sponsor":"Diabeteszentrum Bad Lauterberg im Harz","startDate":"2007-03","conditions":"Stress, Type 1 Diabetes","enrollment":32}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2950,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["r-hGH","Somatropin"],"phase":"phase_3","status":"active","brandName":"Saizen® B","genericName":"Saizen® B","companyName":"Merck KGaA, Darmstadt, Germany","companyId":"merck-kgaa-darmstadt-germany","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Saizen B is a recombinant human growth hormone used to treat growth hormone deficiency. Used for Growth hormone deficiency in children.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}