{"id":"sacubitril-valsartan-oral-tablet-entresto","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"hypotension"},{"rate":"5-10%","effect":"dizziness"},{"rate":"5-10%","effect":"cough"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Sacubitril works by increasing the levels of a naturally occurring enzyme called ACE2, which breaks down angiotensin II. Valsartan blocks the action of angiotensin II, a potent vasoconstrictor, by binding to its receptor. This dual mechanism of action leads to vasodilation and decreased blood pressure.","oneSentence":"Sacubitril is an angiotensin-converting enzyme 2 (ACE2) activator, while valsartan is an angiotensin II receptor antagonist.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:33:12.232Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chronic heart failure"}]},"trialDetails":[],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["ARNI","LCZ696 100 mg tablet","Angiotensin receptor-neprilisin inhibitor (ARNI)","LCZ696"],"phase":"phase_3","status":"active","brandName":"Sacubitril / Valsartan Oral Tablet [Entresto]","genericName":"Sacubitril / Valsartan Oral Tablet [Entresto]","companyName":"University Hospital, Grenoble","companyId":"university-hospital-grenoble","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Sacubitril is an angiotensin-converting enzyme 2 (ACE2) activator, while valsartan is an angiotensin II receptor antagonist. Used for Chronic heart failure.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":2,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}