{"id":"s8-sinus-implant","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Nasal discomfort"},{"rate":"5-10%","effect":"Nasal bleeding"},{"rate":"5-10%","effect":"Headache"}]},"_chembl":{"chemblId":"CHEMBL3902201","moleculeType":"Small molecule","molecularWeight":"576.55"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"The implant is designed to provide sustained release of the corticosteroid, which helps to reduce inflammation and swelling in the nasal passages. This can provide relief for patients with chronic sinusitis or other nasal conditions.","oneSentence":"S8 Sinus Implant is a drug that delivers corticosteroids directly to the nasal passages to reduce inflammation and swelling.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:33:11.150Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Treatment of chronic sinusitis"},{"name":"Treatment of nasal polyps"}]},"trialDetails":[{"nctId":"NCT03358329","phase":"PHASE3","title":"Safety Evaluation of Repeat Placement of the S8 Sinus Implant in Chronic Sinusitis Patients With Nasal Polyps (ENCORE)","status":"COMPLETED","sponsor":"Intersect ENT","startDate":"2017-11-13","conditions":"Chronic Sinusitis, Nasal Polyposis","enrollment":50},{"nctId":"NCT02291549","phase":"PHASE3","title":"S8 Sinus Implant in Chronic Sinusitis Patients With Recurrent Nasal Polyps","status":"COMPLETED","sponsor":"Intersect ENT","startDate":"2014-12","conditions":"Chronic Sinusitis, Nasal Polyposis","enrollment":300},{"nctId":"NCT01732536","phase":"PHASE2, PHASE3","title":"Steroid-Releasing S8 Sinus Implant for Recurrent Nasal Polyps","status":"COMPLETED","sponsor":"Intersect ENT","startDate":"2013-01","conditions":"Chronic Sinusitis, Nasal Polyps","enrollment":100},{"nctId":"NCT01894503","phase":"PHASE2","title":"Safety and Performance of the Steroid-Releasing S8 Sinus Implant","status":"COMPLETED","sponsor":"Intersect ENT","startDate":"2013-06","conditions":"Chronic Sinusitis","enrollment":5}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["SINUVA (mometasone furoate) sinus implant"],"phase":"phase_3","status":"active","brandName":"S8 Sinus Implant","genericName":"S8 Sinus Implant","companyName":"Intersect ENT","companyId":"intersect-ent","modality":"Small molecule","firstApprovalDate":"","aiSummary":"The S8 Sinus Implant is a small molecule implant used to treat conditions such as chronic sinusitis, nasal polyps, and nasal polyposis. It is designed to be used in post-sinus surgery patients with recurrent sinus obstruction.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}