{"id":"s5g4t-2","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Skin irritation"},{"rate":"5-10%","effect":"Dry skin"},{"rate":"5-10%","effect":"Redness"}]},"_chembl":{"chemblId":"CHEMBL299613","moleculeType":"Small molecule","molecularWeight":"302.41"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"By activating these receptors, S5G4T-2 helps to regulate the growth and differentiation of skin cells, leading to improved symptoms of acne and other skin conditions. This mechanism of action is similar to other retinoid-based treatments, but the topical gel formulation of S5G4T-2 allows for more targeted delivery and potentially reduced systemic side effects.","oneSentence":"S5G4T-2 is a topical gel formulation of a retinoid, which works by modulating the activity of retinoic acid receptors in the skin.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:33:11.022Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acne vulgaris"}]},"trialDetails":[{"nctId":"NCT03564119","phase":"PHASE3","title":"A Study of S5G4T-1 in the Treatment of Papularpustular Rosacea","status":"COMPLETED","sponsor":"Sol-Gel Technologies, Ltd.","startDate":"2018-06-21","conditions":"Papulopustular Rosacea","enrollment":372},{"nctId":"NCT03448939","phase":"PHASE3","title":"A Study of S5G4T-1 in the Treatment of Papulopustular Rosacea","status":"COMPLETED","sponsor":"Sol-Gel Technologies, Ltd.","startDate":"2018-06-18","conditions":"Papulopustular Rosacea","enrollment":361}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Vehicle cream"],"phase":"phase_3","status":"active","brandName":"S5G4T-2","genericName":"S5G4T-2","companyName":"Sol-Gel Technologies, Ltd.","companyId":"sol-gel-technologies-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"S5G4T-2 is a topical gel formulation of a retinoid, which works by modulating the activity of retinoic acid receptors in the skin. Used for Acne vulgaris.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":2,"withResults":2},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}