{"id":"s-nitrendipine","rwe":[],"tags":[{"label":"(S)-nitrendipine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Voltage-dependent L-type calcium channel subunit alpha-1D","category":"target"},{"label":"CACNA1D","category":"gene"},{"label":"KCNN4","category":"gene"},{"label":"CACNA1F","category":"gene"},{"label":"Active","category":"status"},{"label":"Hypertensive disorder","category":"indication"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"(-)-nitrendipine","offLabel":[],"synonyms":["(S)-nitrendipine","(-)-Nitrendipine"],"timeline":[],"brandName":"(-)-Nitrendipine","ecosystem":[{"indication":"Hypertensive disorder","otherDrugs":[{"name":"acebutolol","slug":"acebutolol","company":"Promius Pharma"},{"name":"aliskiren","slug":"aliskiren","company":"Novartis"},{"name":"amiloride","slug":"amiloride","company":"Paddock Llc"},{"name":"amlodipine","slug":"amlodipine","company":"Pfizer"}],"globalPrevalence":null}],"mechanism":{"target":"Voltage-dependent L-type calcium channel subunit alpha-1D","targets":[{"gene":"CACNA1D","source":"DrugCentral","target":"Voltage-dependent L-type calcium channel subunit alpha-1D","protein":"Voltage-dependent L-type calcium channel subunit alpha-1D"},{"gene":"KCNN4","source":"DrugCentral","target":"Intermediate conductance calcium-activated potassium channel protein 4","protein":"Intermediate conductance calcium-activated potassium channel protein 4"},{"gene":"CACNA1F","source":"DrugCentral","target":"Voltage-dependent L-type calcium channel subunit alpha-1F","protein":"Voltage-dependent L-type calcium channel subunit alpha-1F"},{"gene":"CACNA1C","source":"DrugCentral","target":"Voltage-dependent L-type calcium channel subunit alpha-1C","protein":"Voltage-dependent L-type calcium channel subunit alpha-1C"}],"modality":"Small Molecule","drugClass":"(S)-nitrendipine","explanation":"Imagine your blood vessels are like roads in your body. When they're narrow, it's harder for blood to flow through them. Nitrendipine helps to widen these roads by blocking the flow of calcium, which is like a traffic controller that makes the roads narrower. This makes it easier for blood to flow, and your blood pressure goes down.","oneSentence":"Nitrendipine works by blocking calcium channels in the heart and blood vessels, which helps to relax and widen blood vessels, reducing blood pressure.","technicalDetail":"Nitrendipine selectively binds to the alpha-1D subunit of the L-type calcium channel, inhibiting the influx of calcium ions into vascular smooth muscle cells and cardiac muscle cells, leading to vasodilation and reduced cardiac contractility."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/6","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=(S)-nitrendipine","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T08:18:25.095790","biosimilars":[],"competitors":[{"drugName":"chlorzoxazone","drugSlug":"chlorzoxazone","fdaApproval":"1958-08-15","genericCount":21,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"clotrimazole","drugSlug":"clotrimazole","fdaApproval":"1975-02-03","patentExpiry":"May 26, 2042","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"riluzole","drugSlug":"riluzole","fdaApproval":"1995-12-12","patentExpiry":"Mar 12, 2029","patentStatus":"Patent protected","relationship":"same-target"}],"genericName":"(s)-nitrendipine","indications":{"approved":[{"name":"Hypertensive disorder","source":"DrugCentral","snomedId":38341003,"regulator":"FDA"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"chlorzoxazone","brandName":"chlorzoxazone","genericName":"chlorzoxazone","approvalYear":"1958","relationship":"same-target"},{"drugId":"clotrimazole","brandName":"clotrimazole","genericName":"clotrimazole","approvalYear":"1975","relationship":"same-target"},{"drugId":"riluzole","brandName":"riluzole","genericName":"riluzole","approvalYear":"1995","relationship":"same-target"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"I3TBK07DB4","CHEBI":"CHEBI:135522","ChEMBL_ID":"CHEMBL251230","PUBCHEM_CID":"157702"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":4,"therapeuticAreas":["Cardiovascular"],"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"-)-Nitrendipine ((S)-nitrendipine) is a small molecule drug that targets the voltage-dependent L-type calcium channel subunit alpha-1D. It is classified as a calcium channel blocker, specifically a dihydropyridine. This medication is used to treat hypertensive disorders by reducing blood pressure. The commercial status of -)-Nitrendipine is currently unknown, and it may be patented or have generic manufacturers. As a pharma professional, it is essential to consider the potential side effects and interactions of this medication.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":false,"score":2}}