{"id":"s-nicardipine","rwe":[],"tags":[{"label":"(S)-nicardipine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Voltage-gated L-type calcium channel","category":"target"},{"label":"CACNA1C","category":"gene"},{"label":"CACNA1D","category":"gene"},{"label":"Active","category":"status"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"(-)-nicardipine","offLabel":[],"synonyms":["(S)-nicardipine","(-)-Nicardipine"],"timeline":[],"brandName":"(-)-Nicardipine","ecosystem":[],"mechanism":{"target":"Voltage-gated L-type calcium channel","targets":[{"gene":"CACNA1C","source":"DrugCentral","target":"Voltage-gated L-type calcium channel","protein":"Voltage-dependent L-type calcium channel subunit alpha-1C"},{"gene":"CACNA1D","source":"DrugCentral","target":"Voltage-gated L-type calcium channel","protein":"Voltage-dependent L-type calcium channel subunit alpha-1D"}],"modality":"Small Molecule","drugClass":"(S)-nicardipine","explanation":"Imagine your heart and blood vessels are like a garden hose. Calcium ions help control how much water flows through the hose. Nicardipine acts like a valve that reduces the flow of calcium ions, making it easier for your heart to pump blood and your blood vessels to relax.","oneSentence":"Nicardipine works by blocking calcium channels to reduce blood pressure and heart rate.","technicalDetail":"Nicardipine selectively binds to the alpha-1 subunit of the L-type calcium channel, inhibiting the voltage-dependent activation of the channel and reducing the influx of calcium ions into cardiac and smooth muscle cells."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/5","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=%28S%29-nicardipine","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=(S)-nicardipine","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T08:18:18.137720","biosimilars":[],"competitors":[{"drugName":"nicardipine","drugSlug":"nicardipine","fdaApproval":"1988-12-21","patentExpiry":"Dec 26, 2027","patentStatus":"Patent protected","relationship":"same-target"}],"genericName":"(s)-nicardipine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"nicardipine","brandName":"nicardipine","genericName":"nicardipine","approvalYear":"1988","relationship":"same-target"}],"trialDetails":[{"nctId":"NCT00803634","phase":"PHASE3","title":"Clevidipine in the Treatment of Blood Pressure in Patients With Acute Heart Failure (PRONTO)","status":"COMPLETED","sponsor":"The Medicines Company","startDate":"2008-12","conditions":["Hypertension","Heart Failure"],"enrollment":117,"completionDate":"2012-03"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"3JT3BYK2JW","CHEBI":"CHEBI:180904","PUBCHEM_CID":"6604415"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":4,"therapeuticAreas":["Cardiovascular"],"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"-)-Nicardipine ((S)-nicardipine) is a small molecule drug that targets voltage-gated L-type calcium channels. It is a member of the dihydropyridine class of calcium channel blockers. The drug's commercial status and approved indications are unknown. Further research is needed to determine its safety profile and potential uses. As a calcium channel blocker, it works by inhibiting the influx of calcium ions into cardiac and smooth muscle cells.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}