{"id":"s-ketamine-0-25","safety":{"commonSideEffects":[{"rate":null,"effect":"Dissociation"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Increased blood pressure"},{"rate":null,"effect":"Tachycardia"},{"rate":null,"effect":"Hallucinations"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"S-Ketamine is the active S-enantiomer of ketamine, which acts as a non-competitive antagonist at the N-methyl-D-aspartate (NMDA) receptor, a subtype of glutamate receptor. This blockade interrupts excitatory neurotransmission in the central nervous system, producing dissociative anesthesia, analgesia, and sedation. The S-enantiomer is approximately 3–4 times more potent than the racemic mixture and has a faster onset and shorter duration of action.","oneSentence":"S-Ketamine is an NMDA receptor antagonist that blocks glutamate signaling in the brain, producing rapid-onset anesthetic and analgesic effects.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:37:27.697Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Induction and maintenance of general anesthesia"},{"name":"Acute pain management"},{"name":"Treatment-resistant depression (investigational)"}]},"trialDetails":[{"nctId":"NCT07063108","phase":"PHASE4","title":"Efficacy and Safety of S-ketamine in Elderly Patients Undergoing Non-cardiac Surgery: a RCT（ESSENCE）","status":"NOT_YET_RECRUITING","sponsor":"Chinese PLA General Hospital","startDate":"2025-12-01","conditions":"Postoperative Pain","enrollment":276},{"nctId":"NCT06744361","phase":"PHASE2","title":"Ketamine Sedation As Neuroprotective Agent Following Out-of-hospital Cardiac Arrest","status":"RECRUITING","sponsor":"Christian Hassager","startDate":"2024-12-12","conditions":"Out-of-hospital Cardiac Arrest (OHCA)","enrollment":282},{"nctId":"NCT02543385","phase":"NA","title":"S Ketamine Use in Total Abdominal Hysterectomy","status":"WITHDRAWN","sponsor":"KK Women's and Children's Hospital","startDate":"2014-06","conditions":"Total Abdominal Hysterectomy","enrollment":""},{"nctId":"NCT05466708","phase":"PHASE4","title":"Safety and Efficacy of Esketamine Combined With Dexmedetomidine for Sedation of Mechanically Ventilated Patients","status":"RECRUITING","sponsor":"The First Affiliated Hospital with Nanjing Medical University","startDate":"2022-08-11","conditions":"Dexmedetomidine, Ketamine, Analgesia","enrollment":100},{"nctId":"NCT05180318","phase":"PHASE4","title":"Prophylactic Effects of Esketamine in Surgical Patients","status":"WITHDRAWN","sponsor":"Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","startDate":"2024-10-01","conditions":"Surgical Injury","enrollment":""},{"nctId":"NCT05321160","phase":"NA","title":"Comparison of the Sedation Effect of Esketamine and Sevoflurane for Pediatric Ophthalmological Procedure","status":"COMPLETED","sponsor":"Eye & ENT Hospital of Fudan University","startDate":"2022-03-28","conditions":"Adverse Event","enrollment":116},{"nctId":"NCT04834427","phase":"PHASE4","title":"Safety and Efficacy Evaluation of S (+) - 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Used for Induction and maintenance of general anesthesia, Acute pain management, Treatment-resistant depression (investigational).","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}