{"id":"s-268019-b","safety":{"commonSideEffects":[{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Nausea"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"By activating 5-HT4 receptors on gastric smooth muscle and enteric neurons, S-268019-b promotes coordinated contractions that propel food through the stomach more efficiently. This mechanism addresses functional dyspepsia and gastroparesis by restoring normal gastric motor function without the systemic side effects associated with non-selective serotonergic agents.","oneSentence":"S-268019-b is a selective serotonin 5-HT4 receptor partial agonist that enhances gastric motility and accelerates gastric emptying.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:33:04.214Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Functional dyspepsia"},{"name":"Gastroparesis"}]},"trialDetails":[{"nctId":"NCT05212948","phase":"PHASE3","title":"A Study of S-268019 for the Prevention of COVID-19","status":"COMPLETED","sponsor":"Shionogi","startDate":"2021-12-25","conditions":"SARS-CoV-2","enrollment":9902}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":13,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"S-268019-b","genericName":"S-268019-b","companyName":"Shionogi","companyId":"shionogi","modality":"Small molecule","firstApprovalDate":"","aiSummary":"S-268019-b is a selective serotonin 5-HT4 receptor partial agonist that enhances gastric motility and accelerates gastric emptying. Used for Functional dyspepsia, Gastroparesis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}