{"id":"s-1-single","safety":{"commonSideEffects":[{"rate":"30-50","effect":"Nausea and vomiting"},{"rate":"20-40","effect":"Diarrhea"},{"rate":"20-30","effect":"Anorexia"},{"rate":"10-30","effect":"Bone marrow suppression (leukopenia, thrombocytopenia)"},{"rate":"5-15","effect":"Hand-foot syndrome"},{"rate":"5-15","effect":"Stomatitis"}]},"_chembl":{"chemblId":"CHEMBL2074774","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"S-1 combines tegafur (a prodrug of 5-fluorouracil), gimeracil (an inhibitor of dihydropyrimidine dehydrogenase), and oteracil potassium (an inhibitor of orotate phosphoribosyltransferase). This triple combination enhances 5-FU bioavailability and reduces gastrointestinal toxicity by modulating fluoropyrimidine metabolism, leading to prolonged anti-tumor effects.","oneSentence":"S-1 is an oral combination chemotherapy agent that inhibits thymidylate synthase and other folate metabolism enzymes to disrupt DNA synthesis in cancer cells.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:32:59.339Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Gastric cancer"},{"name":"Colorectal cancer"},{"name":"Pancreatic cancer"}]},"trialDetails":[{"nctId":"NCT05771480","phase":"PHASE3","title":"Durvalumab With Chemotherapy as First Line Treatment in Patients With Advanced Biliary Tract Cancers (aBTCs)","status":"ACTIVE_NOT_RECRUITING","sponsor":"AstraZeneca","startDate":"2023-08-16","conditions":"Biliary Tract Cancer","enrollment":142},{"nctId":"NCT07492615","phase":"PHASE2","title":"A Clinical Study of Sintilimab Combined With Chemothrapy Versus Chemotherapy as Adjuvant Therapy for Gastric/Gastroesophageal Junction Adenocarcinoma","status":"RECRUITING","sponsor":"Fudan University","startDate":"2026-01-29","conditions":"Gastric Cancer or Gastroesophageal Junction Adenocarcinoma","enrollment":276},{"nctId":"NCT06538623","phase":"PHASE2","title":"Oxaliplatin Combined With Irinotecan Liposome Injection II Through Hepatic Artery Infusion (HAIC) Followed by 5-FU/LV (HAIC) or Tegorgor Oral Combination Therapy for Hepatic Metastasis of Pancreatic Cancer","status":"COMPLETED","sponsor":"Ruijin Hospital","startDate":"2024-08-23","conditions":"Pancreatic Neoplasms, Neoplasm Metastasis, Hepatic Metastasis of Pancreatic Cancer","enrollment":40},{"nctId":"NCT07169318","phase":"PHASE1","title":"First-in-Human Study of VNT-101: Safety, Tolerability, and Pharmacokinetics","status":"RECRUITING","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2025-09-16","conditions":"Influenza","enrollment":78},{"nctId":"NCT07474324","phase":"PHASE2","title":"Disitamab Vedotin Combined With SOX Regimen Versus SOX Alone as Adjuvant Therapy for HER2-Moderate/High Expressing Stage Ⅲ Gastric Cancer: A Prospective, Multicenter, Randomized, Phase Ⅱ Clinical Trial","status":"RECRUITING","sponsor":"The First Affiliated Hospital with Nanjing Medical University","startDate":"2026-03-15","conditions":"GC/GEJC","enrollment":124},{"nctId":"NCT07467473","phase":"NA","title":"Causal Role of Rostromedial Prefrontal Cortex for Positive Savoring in Depression","status":"ENROLLING_BY_INVITATION","sponsor":"Florida State University","startDate":"2026-03-23","conditions":"Left Rostromedial Prefrontal Cortex - Accelerated Intermittent Theta Burst, Left Dorsolateral Prefrontal Cortex - Accelerated Intermittent Theta Burst, Left Primary Somatosensory Cortex - Accelerated Intermittent Theta Burst","enrollment":48},{"nctId":"NCT06778447","phase":"NA","title":"Clinical Trial Evaluating the Safety and Efficacy of Nucleus Pulposus Allograft in Participants With Degenerative Disc Disease","status":"RECRUITING","sponsor":"VIVEX Biologics, Inc.","startDate":"2025-02-17","conditions":"Degenerative Disc Disease, Disc Degeneration, Lumbar Discogenic Pain","enrollment":496},{"nctId":"NCT05152810","phase":"NA","title":"Effectiveness of Transcranial Magnetic Stimulation (TMS) in Smoking Cessation, Combining Withdrawal Stimulation Followed by Maintenance Stimulation to Prevent Relapse","status":"COMPLETED","sponsor":"Centre Hospitalier Universitaire Dijon","startDate":"2022-01-06","conditions":"Smoking Cessation","enrollment":88},{"nctId":"NCT05535166","phase":"PHASE2","title":"Molecular and Clinical Risk-Directed Therapy for Infants and Young Children With Newly Diagnosed Medulloblastoma","status":"RECRUITING","sponsor":"St. Jude Children's Research Hospital","startDate":"2022-12-20","conditions":"Medulloblastoma","enrollment":130},{"nctId":"NCT06061770","phase":"NA","title":"Comparison of the Effectiveness of an Adapted Physical Activity Program in a Dedicated Structure to a Self-program in Patients in Chronic Phase of a Stroke","status":"RECRUITING","sponsor":"Assistance Publique Hopitaux De Marseille","startDate":"2024-09-27","conditions":"Stroke","enrollment":40},{"nctId":"NCT07374250","phase":"PHASE2","title":"Perioperative Ivonescimab Plus S-1 and Oxaliplatin (SOX) for Locally Advanced Gastric or GEJ Adenocarcinoma","status":"NOT_YET_RECRUITING","sponsor":"Sichuan University","startDate":"2026-02-01","conditions":"Gastric Cancer, RCT","enrollment":154},{"nctId":"NCT07214844","phase":"NA","title":"A Prospective Study to Evaluate the Efficacy of Iovera Lumbar Medial Branch Cryoneurolysis Versus Radiofrequency Ablation for the Treatment of Chronic Low Back Pain","status":"RECRUITING","sponsor":"Montefiore Medical Center","startDate":"2026-02","conditions":"Low Back Pain, Chronic","enrollment":110},{"nctId":"NCT07370233","phase":"PHASE2","title":"Triple Therapy Strategy for Managing Persistent Pain After Spinal Microdiscectomy","status":"COMPLETED","sponsor":"Benha University","startDate":"2023-02-20","conditions":"Spinal Disk Injury","enrollment":63},{"nctId":"NCT06510010","phase":"PHASE2","title":"Perioperative Oxaliplatin With S-1 Combined H. Pylori Eradication in the Management of Locally Advanced Gastric Cancer","status":"RECRUITING","sponsor":"Sixth Affiliated Hospital, Sun Yat-sen University","startDate":"2024-12-31","conditions":"Chemotherapy Effect","enrollment":198},{"nctId":"NCT06468280","phase":"PHASE2","title":"Synergistic Effects of PD-1 Antibody and Chemotherapy/Targeted Therapy Followed by Surgery-centric Local Treatment in Patients With Limited-metastatic Gastric Cancer","status":"RECRUITING","sponsor":"Shanghai Zhongshan Hospital","startDate":"2024-11-08","conditions":"Gastric Cancer, GastroEsophageal Cancer","enrollment":84},{"nctId":"NCT07356466","phase":"EARLY_PHASE1","title":"Clinical Efficacy of Pucotenlimab Combined With Lenvatinib and SOX Versus SOX Alone in Patients With HER2-Negative Advanced Gastric or Gastroesophageal Junction Adenocarcinoma","status":"ENROLLING_BY_INVITATION","sponsor":"Fujian Medical University","startDate":"2025-05-01","conditions":"Gastric (Stomach) Cancer","enrollment":100},{"nctId":"NCT07353684","phase":"PHASE2","title":"Adebrelimab, Apatinib & SOX for Conversion Therapy in Advanced Gastric/GEJ Cancer","status":"RECRUITING","sponsor":"Beijing Friendship Hospital","startDate":"2025-05-11","conditions":"Adebrelimab, Adenocarcinoma of GE Junction, Adenocarcinoma of Stomach","enrollment":49},{"nctId":"NCT07075770","phase":"NA","title":"Novel Personalized Non Invasive Combined Magnetic and Electrical Stimulation of the DMN in Mild AD Patients","status":"RECRUITING","sponsor":"I.R.C.C.S. Fondazione Santa Lucia","startDate":"2025-01-01","conditions":"Alzheimer Disease","enrollment":60},{"nctId":"NCT05145595","phase":"NA","title":"Pain Sensitivity During Puberty","status":"COMPLETED","sponsor":"Washington University School of Medicine","startDate":"2022-09-20","conditions":"Pain","enrollment":36},{"nctId":"NCT07325630","phase":"PHASE2","title":"Perioprative Study of IBI363 in Patients With MHC-II-Negative Locally Advanced Gastric Cancer","status":"RECRUITING","sponsor":"Zhejiang Cancer Hospital","startDate":"2025-11-03","conditions":"IBI363 + Chemotherapy","enrollment":60},{"nctId":"NCT04481750","phase":"PHASE1","title":"Study of Oral Edaravone in Healthy Adult Males","status":"COMPLETED","sponsor":"Tanabe Pharma Corporation","startDate":"2018-03-20","conditions":"Healthy Adult Subjects","enrollment":74},{"nctId":"NCT07038629","phase":"PHASE2","title":"Chemoradiation Plus Iparomlimab Consolidation in Older With ESCC","status":"RECRUITING","sponsor":"Tianjin Medical University Cancer Institute and Hospital","startDate":"2025-03-01","conditions":"Esophageal Cancer","enrollment":52},{"nctId":"NCT07315854","phase":"PHASE2","title":"Iparomlimab and Tuvonralimab (QL1706) Combined With Chemotherapy for Previously Untreated Advanced or Metastatic Gastric or Gastroesophageal Junction Cancer","status":"RECRUITING","sponsor":"Beijing Friendship Hospital","startDate":"2025-11-04","conditions":"Gastric Cancer (GC), Gastroesophageal Junction Cancer, Advanced Gastric Cancer","enrollment":32},{"nctId":"NCT07315035","phase":"PHASE2","title":"QL1706-SOX vs SOX Alone as Neoadjuvant Therapy for Resectable Diffuse-Type Gastric Cancer","status":"NOT_YET_RECRUITING","sponsor":"The First Affiliated Hospital with Nanjing Medical University","startDate":"2026-01-01","conditions":"Gastric Cancer Stage III","enrollment":74},{"nctId":"NCT07304258","phase":"PHASE2","title":"A Prospective, Phase II Clinical Study of HIPEC Combined With NIPS and Tislelizumab Conversion Therapy for Gastric Cancer With Peritoneal Metastasis With Positive Cytology Alone or PCI Score ≤10","status":"NOT_YET_RECRUITING","sponsor":"Hebei Medical University","startDate":"2025-12-12","conditions":"Gastric Cancer Peritoneal Metastases","enrollment":30},{"nctId":"NCT07297914","phase":"PHASE2, PHASE3","title":"Framework for Optimizing, Refining, and Unifying Management of HSCT in Pediatric ALL","status":"NOT_YET_RECRUITING","sponsor":"Bambino Gesù Hospital and Research Institute","startDate":"2026-01-15","conditions":"Acute Lymphoblastic Leukemia (ALL), Stem Cell Transplant, Graft -Versus-host-disease","enrollment":1000},{"nctId":"NCT07285824","phase":"NA","title":"Virtual McKenzie Exercises and Centralization of Pain: A Pilot Study","status":"NOT_YET_RECRUITING","sponsor":"Evidence In Motion","startDate":"2025-12","conditions":"Chronic Pain, Low Back Pain","enrollment":40},{"nctId":"NCT06236009","phase":"PHASE1","title":"A First-In-Human Study of TAK-004 in Healthy Adults","status":"COMPLETED","sponsor":"Takeda","startDate":"2024-11-01","conditions":"Healthy Volunteers","enrollment":121},{"nctId":"NCT06584227","phase":"PHASE2","title":"Adebrelimab and Chidamide for Pancreatic Cancer","status":"RECRUITING","sponsor":"Liu Xiufeng","startDate":"2024-09-10","conditions":"Pancreatic Cancer, Adult","enrollment":45},{"nctId":"NCT07263386","phase":"PHASE2","title":"A Phase II, Multicenter, Randomized, Controlled Clinical Study Comparing the Efficacy and Safety of Sintilimab Plus SOX Versus SOX Alone as Adjuvant Therapy for PD-L1-Positive, Stage pN3 Gastric Cancer","status":"RECRUITING","sponsor":"The First Affiliated Hospital with Nanjing Medical University","startDate":"2025-10-23","conditions":"Gastric Adenocarcinoma","enrollment":460},{"nctId":"NCT07204106","phase":"NA","title":"Efficacy Study of Dexmedetomidine Nasal Spray Combined With Propofol for Deep Sedation in ERCP","status":"COMPLETED","sponsor":"Shiyou Wei","startDate":"2025-10-02","conditions":"Dexmedetomidine Induced Sedation, Nasal Administration, Sprays","enrollment":180},{"nctId":"NCT03449108","phase":"PHASE2","title":"LN-145 or LN-145-S1 in Treating Patients With Relapsed or Refractory Ovarian Cancer, Triple Negative Breast Cancer (TNBC), Anaplastic Thyroid Cancer, Osteosarcoma, or Other Bone and Soft Tissue Sarcomas","status":"ACTIVE_NOT_RECRUITING","sponsor":"M.D. Anderson Cancer Center","startDate":"2018-04-27","conditions":"Bone Sarcoma, Dedifferentiated Chondrosarcoma, Giant Cell Tumor of Bone","enrollment":30},{"nctId":"NCT07154979","phase":"NA","title":"Oliceridine Dose for Tracheal Intubation Hemodynamic Elevation: Up-and-Down Trial","status":"COMPLETED","sponsor":"Shiyou Wei","startDate":"2025-09-04","conditions":"Oliceridine","enrollment":58},{"nctId":"NCT06755593","phase":"NA","title":"Effectiveness of Intravascular Laser Therapy on Sleep Quality in Patients With Chronic Low Back Pain: A Randomized Controlled Trial","status":"COMPLETED","sponsor":"Le Hoang Minh Quan","startDate":"2024-04-01","conditions":"Sleep Disorders, Sciatica","enrollment":66},{"nctId":"NCT07228819","phase":"NA","title":"Sustainability Via Active Garden Education Wellness Implementation Strategies in Early Care and Education","status":"ENROLLING_BY_INVITATION","sponsor":"Arizona State University","startDate":"2025-10-02","conditions":"Implementation Science, Diet, Food, and Nutrition, Child Care","enrollment":871},{"nctId":"NCT06874959","phase":"NA","title":"Evaluation of the Pain Relief Effect of Battlefield Acupuncture on Patients With Chronic Low Back Pain Due to Lumbar Spine Degeneration.","status":"COMPLETED","sponsor":"University of Medicine and Pharmacy at Ho Chi Minh City","startDate":"2025-03-15","conditions":"Spondylosis Lumbar","enrollment":60},{"nctId":"NCT07169240","phase":"PHASE1","title":"Evaluation of Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of BT-114143 Injection in Healthy Subjects","status":"COMPLETED","sponsor":"ScinnoHub Pharmaceutical Co., Ltd.","startDate":"2023-02-06","conditions":"Healthy Subjects (HS)","enrollment":84},{"nctId":"NCT04385290","phase":"PHASE1, PHASE2","title":"Combination of Midostaurin and Gemtuzumab Ozogamicin in First-line Standard Therapy for Acute Myeloid Leukemia (MOSAIC)","status":"RECRUITING","sponsor":"Technische Universität Dresden","startDate":"2020-09-04","conditions":"Acute Myeloid Leukemia","enrollment":214},{"nctId":"NCT07156513","phase":"NA","title":"Persistent Post-Lumbar Surgery Pain Syndrome (PSPS) Type II is a Common Condition Encountered in Pain Units, With Limited Available Therapeutic Options. Epidural Pulsed Radiofrequency (PRF) Administered Via Catheter Has Demonstrated Greater Efficacy Compared to the Transforaminal Approach. This Rand","status":"COMPLETED","sponsor":"Puerta de Hierro University Hospital","startDate":"2021-01-02","conditions":"Persistent Spinal Pain Syndrome Type II, Failed Back Surgery Syndrome, Chronic Low Back Pain","enrollment":131},{"nctId":"NCT05944081","phase":"","title":"Postmarket Clinical Follow-Up Study on Arcadius XP L® Interbody Fusion Device","status":"WITHDRAWN","sponsor":"Aesculap AG","startDate":"2024-03-15","conditions":"Chronic Low-back Pain, Degenerative Disc Disease, Spondylolysis Lumbar","enrollment":""},{"nctId":"NCT07007182","phase":"PHASE2","title":"Conversion Therapy Plus Surgery and Radiotherapy for Retroperitoneal Nodal Metastases in Gastric Cancer","status":"NOT_YET_RECRUITING","sponsor":"Jinbo Yue","startDate":"2025-10-01","conditions":"Gastric Adenocarcinoma, Stomach Neoplasms","enrollment":54},{"nctId":"NCT07151209","phase":"PHASE2","title":"Immunotherapy Combined With Anti-angiogenic Therapy and Chemotherapy for Potentially Resectable MSI-H, dMMR Locally Advanced Gastric or Gastroesophageal Junction Adenocarcinoma","status":"NOT_YET_RECRUITING","sponsor":"The First Affiliated Hospital with Nanjing Medical University","startDate":"2025-09","conditions":"Gastric or Gastroesophageal Junction Adenocarcinoma","enrollment":20},{"nctId":"NCT07151651","phase":"NA","title":"A Comparison Between Biportal and Uniportal Endoscopic Lumbar Discectomy","status":"NOT_YET_RECRUITING","sponsor":"Sohag University","startDate":"2025-09-01","conditions":"Lumbar Disc Herniation","enrollment":60},{"nctId":"NCT03199729","phase":"NA","title":"Aging and Mixed Perturbation Training to Reduce Falls in Locomotion","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of Illinois at Chicago","startDate":"2017-08-01","conditions":"Older Adults","enrollment":600},{"nctId":"NCT05884593","phase":"NA","title":"Analysis of Pedicle Screw Accuracy to Plan Using Medtronic Mazor Robotic System","status":"ACTIVE_NOT_RECRUITING","sponsor":"Ohio State University","startDate":"2021-03-05","conditions":"Spinal Deformity, Spinal Infection, Trauma","enrollment":50},{"nctId":"NCT03115983","phase":"NA","title":"LimiFlex Clinical Trial for the Treatment of Degenerative Spondylolisthesis With Spinal Stenosis","status":"ACTIVE_NOT_RECRUITING","sponsor":"Empirical Spine, Inc.","startDate":"2017-07-17","conditions":"Degenerative Spondylolisthesis, Lumbar Spinal Stenosis","enrollment":299},{"nctId":"NCT03453216","phase":"NA","title":"Impact of Another Person's Presence on Brain and Behavioral Performance","status":"TERMINATED","sponsor":"Hôpital le Vinatier","startDate":"2019-07-01","conditions":"Behavior and Behavior Mechanisms","enrollment":112},{"nctId":"NCT05094609","phase":"PHASE1","title":"Phase 1 Trial of ChAd68 and Ad5 Adenovirus COVID-19 Vaccines Delivered by Aerosol","status":"COMPLETED","sponsor":"McMaster University","startDate":"2022-01-03","conditions":"COVID-19, SARS-CoV2 Infection","enrollment":36},{"nctId":"NCT06966440","phase":"NA","title":"Adjuvant Pancreatic Therapy Guided by MRD","status":"RECRUITING","sponsor":"Ruijin Hospital","startDate":"2025-06-01","conditions":"Pancreatic Adenocarcinoma Resectable","enrollment":856},{"nctId":"NCT03645928","phase":"PHASE2","title":"Study of Autologous Tumor Infiltrating Lymphocytes in Patients With Solid Tumors","status":"RECRUITING","sponsor":"Iovance Biotherapeutics, Inc.","startDate":"2019-05-07","conditions":"Metastatic Melanoma, Squamous Cell Carcinoma of the Head and Neck, Non-small Cell Lung Cancer","enrollment":245},{"nctId":"NCT07018063","phase":"PHASE2","title":"Neoadjuvant Nab-Paclitaxel Plus Oxaliplatin, S-1, and Sintilimab in Early-Onset Resectable Gastric Cancer","status":"NOT_YET_RECRUITING","sponsor":"zhoujing","startDate":"2025-10-01","conditions":"Gastric (Cardia, Body) Cancer, Stomach Adenocarcinoma, Locally Advanced","enrollment":35},{"nctId":"NCT06959602","phase":"NA","title":"Antibacterial Efficacy and Outcomes of Root Canal Irrigation Methods","status":"ENROLLING_BY_INVITATION","sponsor":"National and Kapodistrian University of Athens","startDate":"2025-04-01","conditions":"Pulp Necrosis, Apical Periodontitis, Endodontic Treatment","enrollment":66},{"nctId":"NCT06988956","phase":"PHASE2","title":"Nimotuzumab Plus Definite Chemoradiotherapy(dCRT) in Elderly Patients With Esophageal Squamous Cell Carcinoma","status":"RECRUITING","sponsor":"The First Affiliated Hospital with Nanjing Medical University","startDate":"2024-03-31","conditions":"Esophageal Squamous Cell Carcinoma","enrollment":95},{"nctId":"NCT06611397","phase":"NA","title":"Discogen for Low Back Pain","status":"RECRUITING","sponsor":"Columbia University","startDate":"2025-03-15","conditions":"Disc Herniation","enrollment":5},{"nctId":"NCT05105490","phase":"","title":"Post Market Observational Trial for the PerQdisc Nucleus Replacement Device","status":"WITHDRAWN","sponsor":"Spinal Stabilization Technologies","startDate":"2021-12-31","conditions":"Degenerative Disc Disease, Chronic Low-back Pain","enrollment":""},{"nctId":"NCT06532617","phase":"PHASE2","title":"Cadonilimab Combined With S-1 or Capecitabine as Second-line Treatment for Advanced Pancreatic Cancer","status":"RECRUITING","sponsor":"Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine","startDate":"2024-09-19","conditions":"Pancreatic Neoplasms","enrollment":30},{"nctId":"NCT06422858","phase":"PHASE2","title":"Sequential Tegafur-gimeracil-oteracil Potassium Capsule (s-1) and Serplulimab Following Concurrent Chemoradiotherapy for Esophageal Squamous Cell Carcinoma","status":"RECRUITING","sponsor":"Zhejiang Cancer Hospital","startDate":"2024-05-20","conditions":"Locally Advanced Inoperable Esophageal Squamous Cell Carcinoma","enrollment":37},{"nctId":"NCT06939452","phase":"PHASE2","title":"A Single-arm, Multicenter Exploratory Clinical Trial of Anlotinib Combined With TQB2450 and the SOX Regimen as First-line Treatment for Advanced Gastric Cancer With Low PD-L1 Expression","status":"RECRUITING","sponsor":"Yongxu Jia","startDate":"2023-06-07","conditions":"Advanced Gastric or Gastroesophageal Junction (G/GEJ) Adenocarcinoma","enrollment":37},{"nctId":"NCT06914687","phase":"PHASE2","title":"Efficacy of Tirellizumab Combined With Oral, Intravenous and Abdominal Chemotherapy in Peritoneal Metastatic Gastric/Gastroesophageal Junction Adenocarcinoma","status":"NOT_YET_RECRUITING","sponsor":"Fudan University","startDate":"2025-03-30","conditions":"Gastric Adenocarcinoma, Gastric Adenocarcinoma or Gastroesophageal Junction Adenocarcinoma or Esophageal Carcinoma, Peritoneal Metastasis","enrollment":30},{"nctId":"NCT06779318","phase":"PHASE4","title":"Maintenance Chemotherapy With S-1 vs. Observation After Adjuvant Therapy for Resected Pancreatic Cancer With High Risk of Recurrence/Metastasis","status":"NOT_YET_RECRUITING","sponsor":"The First Affiliated Hospital with Nanjing Medical University","startDate":"2025-07","conditions":"Pancreatic Cancer, Postoperative Adjuvant Therapy, Maintenance Therapy","enrollment":464},{"nctId":"NCT05375708","phase":"PHASE2","title":"Systemic Therapy in Combination with Stereotactic Radiotherapy in Patients with Metastatic Colorectal Cancer Up to 10 Metastatic Sites","status":"SUSPENDED","sponsor":"UMC Utrecht","startDate":"2025-12-01","conditions":"Metastatic Colorectal Cancer, Oligometastatic Disease","enrollment":93},{"nctId":"NCT05223088","phase":"PHASE2","title":"Tislelizumab Combined With Apatinib and Oxaliplatin Plus S1 as Neoadjuvant Therapy for Borrmann IV、Large Borrmann III Type and Bulky N Positive Advanced Gastric Cancer","status":"COMPLETED","sponsor":"Fujian Cancer Hospital","startDate":"2021-10-31","conditions":"Immunotherapy, Gastrict Cancer","enrollment":40},{"nctId":"NCT06870474","phase":"NA","title":"Psychoeducational Intervention Against Support Groups for Caregivers","status":"COMPLETED","sponsor":"University of Salamanca","startDate":"2019-01-10","conditions":"Dementia","enrollment":35},{"nctId":"NCT06204900","phase":"NA","title":"A Post-marketing Study to Evaluate a Novel Surgical Monitoring Technique Using the EARP Nerve Cuff in TLIF Surgery.","status":"RECRUITING","sponsor":"Retropsoas Technologies, LLC","startDate":"2024-06-07","conditions":"Transforaminal Lumbar Interbody Fusion Surgery","enrollment":30},{"nctId":"NCT06833099","phase":"","title":"The Prediction of Recurrence Lumbar Disc Herniation At L5-S1 Level Through Machine Learning Models Based on Endoscopic Discectomy Via the Interlaminar Approach","status":"COMPLETED","sponsor":"Jinyu Chen","startDate":"2020-01-01","conditions":"Recurrent Lumbar Disc Herniation","enrollment":309},{"nctId":"NCT06615505","phase":"PHASE2","title":"ASCEND: A Clinical Trial to Evaluate the Safety and Effectiveness of VIA Disc NP, a Supplement for Degenerated Intervertebral Discs","status":"RECRUITING","sponsor":"VIVEX Biologics, Inc.","startDate":"2024-10-04","conditions":"Degenerative Disc Disease, Disc Degeneration, Lumbar Discogenic Pain","enrollment":110},{"nctId":"NCT06792305","phase":"NA","title":"The Sequence of Fixation in Tile C1.2 and C1.3 Vertical Shear Pelvic Ring Injuries.","status":"RECRUITING","sponsor":"Ain Shams University","startDate":"2024-12-01","conditions":"Pelvic Ring Fractures, Pelvic Ring Injury","enrollment":30},{"nctId":"NCT06774222","phase":"PHASE2","title":"A Study of Fruquintinib Plus Chemotherapy for Postoperative Treatment of HER2-Negative Gastric Cancer With Poor TRG","status":"RECRUITING","sponsor":"Henan Cancer Hospital","startDate":"2023-09-12","conditions":"Gastric/Gastroesophageal Junction Adenocarcinoma","enrollment":69},{"nctId":"NCT06657690","phase":"PHASE2","title":"Irinotecan Liposome Combined with S-1 in PD-1/L1 Inhibitor Refractory Recurrent or Metastatic NPC","status":"RECRUITING","sponsor":"Sun Yat-sen University","startDate":"2024-11-01","conditions":"Recurrent or Metastatic Nasopharyngeal Carcinoma","enrollment":56},{"nctId":"NCT03337607","phase":"NA","title":"Radial Extracorporeal Shock Wave Therapy for Chronic Non-specific Low Back Pain","status":"COMPLETED","sponsor":"First Affiliated Hospital of Zhejiang University","startDate":"2017-11-13","conditions":"Low Back Pain","enrollment":150},{"nctId":"NCT06746545","phase":"PHASE2","title":"A Prospective, Open-label, Single-arm Phase II Clinical Study of Fruquintinib Combined With S-1 for the Treatment of Metastatic Colorectal Cancer.","status":"NOT_YET_RECRUITING","sponsor":"Fujian Cancer Hospital","startDate":"2025-02-01","conditions":"Colorectal Cancer","enrollment":30},{"nctId":"NCT06674525","phase":"PHASE1","title":"Evaluation of 626 in Healthy Adult Subjects","status":"RECRUITING","sponsor":"Sunshine Guojian Pharmaceutical (Shanghai) Co., Ltd.","startDate":"2024-12-02","conditions":"Healthy Subjects (HS)","enrollment":50},{"nctId":"NCT02867839","phase":"PHASE3","title":"Adjuvant Chemotherapy With S-1 Plus Oxaliplatin Versus S-1 Alone in Locally Advanced Gastric Cancer","status":"TERMINATED","sponsor":"Peking University Cancer Hospital & Institute","startDate":"2017-04-24","conditions":"Gastric Cancer","enrollment":29},{"nctId":"NCT06038461","phase":"PHASE1, PHASE2","title":"An Open, Single-center Clinical Study of Surufatinib Combined With Temozolomide and S-1 in the First-line Treatment of Advanced Neuroendocrine Tumors","status":"RECRUITING","sponsor":"Cancer Institute and Hospital, Chinese Academy of Medical Sciences","startDate":"2023-09-15","conditions":"Neuroendocrine Tumors","enrollment":40},{"nctId":"NCT01285557","phase":"PHASE3","title":"Diffuse Gastric and Esophagogastric Junction Cancer S-1 Trial","status":"TERMINATED","sponsor":"Taiho Oncology, Inc.","startDate":"2011-04-14","conditions":"Metastatic Diffuse Gastric Cancer Including Carcinoma of the Gastro-esophageal Junction","enrollment":361},{"nctId":"NCT00651742","phase":"PHASE2","title":"Phase 2 Study of S-1 in Advanced or Metastatic Pancreatic Cancer","status":"COMPLETED","sponsor":"Taiho Oncology, Inc.","startDate":"2006-01-09","conditions":"Locally Advanced or Metastatic Pancreatic Cancer","enrollment":28},{"nctId":"NCT02969122","phase":"NA","title":"Treatment Strategy for Stage IV Gastric Cancer with Positive Peritoneal Cytology As the Only Non-curable Factor","status":"TERMINATED","sponsor":"Peking University","startDate":"2016-11","conditions":"Stomach Neoplasm","enrollment":59},{"nctId":"NCT00398307","phase":"PHASE1","title":"Evaluating Patients With Varying Degrees of Renal Function","status":"COMPLETED","sponsor":"Taiho Oncology, Inc.","startDate":"2006-02","conditions":"Renal Impairment","enrollment":24},{"nctId":"NCT00400023","phase":"PHASE1","title":"A Phase 1, Open-Label, Randomized, Cross-Over, Pharmacokinetic Study Evaluating the Effect of S-1 on Advanced Solid Tumors","status":"COMPLETED","sponsor":"Taiho Oncology, Inc.","startDate":"2006-09","conditions":"Tumors","enrollment":12},{"nctId":"NCT00398424","phase":"PHASE1","title":"Evaluating Patients With Impaired Hepatic Function","status":"COMPLETED","sponsor":"Taiho Oncology, Inc.","startDate":"2006-02","conditions":"Impaired Hepatic Function","enrollment":24},{"nctId":"NCT00651833","phase":"PHASE2","title":"Phase 2 Study of S-1 in Combination With Cisplatin as 1st Line Therapy in Advanced Non-Small Cell Lung Cancer","status":"COMPLETED","sponsor":"Taiho Oncology, Inc.","startDate":"2005-02","conditions":"Advanced Non-Small Cell Lung Cancer","enrollment":60},{"nctId":"NCT00652561","phase":"PHASE2","title":"Phase 2 Study of S-1 as 2nd Line Therapy in Advanced Non-Small Cell Lung Cancer","status":"COMPLETED","sponsor":"Taiho Oncology, Inc.","startDate":"2005-02","conditions":"Advanced Non-Small Cell Lung Cancer","enrollment":57},{"nctId":"NCT00652054","phase":"PHASE2","title":"Phase 2 Study of S-1 as 2nd Line Therapy in Metastatic Pancreatic Cancer","status":"COMPLETED","sponsor":"Taiho Oncology, Inc.","startDate":"2005-06","conditions":"Metastatic Pancreatic Cancer","enrollment":39},{"nctId":"NCT06564298","phase":"PHASE2","title":"A Study on the Combination of Sintilimab, Ramucirumab and Chemotherapy for First-line Treatment of Gastric Cancer With Liver Metastasis","status":"NOT_YET_RECRUITING","sponsor":"The First Affiliated Hospital with Nanjing Medical University","startDate":"2024-08","conditions":"Stomach Neoplasms","enrollment":39},{"nctId":"NCT06555471","phase":"PHASE2","title":"A Single-arm, Phase II Exploratory Study of Sintilimab in Combination With Chemoradiotherapy in Elderly Patients With Locally Advanced Gastric Cancer","status":"RECRUITING","sponsor":"The First Affiliated Hospital with Nanjing Medical University","startDate":"2024-08-06","conditions":"Gastric Cancer","enrollment":40},{"nctId":"NCT06497634","phase":"NA","title":"Effect of Spinal Needle Type on Optic Nerve Sheath Diameter","status":"NOT_YET_RECRUITING","sponsor":"Bagcilar Training and Research Hospital","startDate":"2024-08-15","conditions":"Spinal Anesthesia, Intracranial Pressure Change, Optic Nerve Sheath Diameter","enrollment":165},{"nctId":"NCT06515678","phase":"","title":"Impact of Antihypertensive Therapy on Recurrence Risk of Ovarian Cancer for Bevacizumab-associated Hypertension","status":"ACTIVE_NOT_RECRUITING","sponsor":"Groupe Hospitalier Pitie-Salpetriere","startDate":"2024-05-20","conditions":"Ovarian Cancer, Antiangiogenic-Associated Hypertension, Adjuvant Bevacizumab","enrollment":9464},{"nctId":"NCT06097039","phase":"","title":"Fetuin-A, a Promising Serum Biomarker for Diagnosis of Non-Alcoholic Fatty Liver Disease","status":"COMPLETED","sponsor":"Zagazig University","startDate":"2023-01-01","conditions":"Non-Alcoholic Fatty Liver Disease","enrollment":100},{"nctId":"NCT06511765","phase":"PHASE3","title":"Anesthetic Block of the Erector Muscles of the Lumbar Spine to Relieve Acute Lumbar Pain: Pilot Study","status":"NOT_YET_RECRUITING","sponsor":"Elsan","startDate":"2024-09-01","conditions":"Lumbago","enrollment":40},{"nctId":"NCT06496789","phase":"PHASE2","title":"Neoadjuvant Serplulimab in Combination With Chemotherapy in Locally Advanced Gastric or Gastro-esophageal Junction Cancer","status":"RECRUITING","sponsor":"Tianjin Medical University Cancer Institute and Hospital","startDate":"2023-05-27","conditions":"Gastric Adenocarcinoma","enrollment":35},{"nctId":"NCT06490107","phase":"PHASE2","title":"Durvalumab Combined With S-1 as Adjuvant Therapy of Resectable BTC","status":"ACTIVE_NOT_RECRUITING","sponsor":"Cancer Institute and Hospital, Chinese Academy of Medical Sciences","startDate":"2024-05-24","conditions":"Biliary Tract Cancer","enrollment":40},{"nctId":"NCT06435169","phase":"","title":"Comparative Presence of Piriformis Syndrome in Patients With Lumbar Disc Bulging and Protrusion","status":"COMPLETED","sponsor":"Yuzuncu Yil University","startDate":"2024-03-04","conditions":"Piriformis Syndrome","enrollment":76},{"nctId":"NCT06422156","phase":"PHASE2","title":"SBRT Combined With Nimotuzumab and Mono-chemotherapy in Locally Advanced Pancreatic Cancer","status":"NOT_YET_RECRUITING","sponsor":"Peking University Third Hospital","startDate":"2024-06-01","conditions":"Advanced Pancreatic Cancer","enrollment":73},{"nctId":"NCT06197529","phase":"NA","title":"Is Nociceptive Processing Evoked by Heat Homeostatically Regulated: A Contact-heat Evoked Potentials Study","status":"COMPLETED","sponsor":"Aalborg University","startDate":"2023-11-21","conditions":"Healthy","enrollment":18},{"nctId":"NCT06396585","phase":"PHASE2","title":"The Efficacy and Safety of Tislelizumab Combined With Anlotinib and S1 Plus Oxaliplatin as Neoadjuvant Therapy for the Locally Advanced Adenocarcinoma of Esophagogastric Junction","status":"NOT_YET_RECRUITING","sponsor":"Fujian Cancer Hospital","startDate":"2024-08-01","conditions":"Immunotherapy Gastroesophageal Junction","enrollment":28},{"nctId":"NCT03358563","phase":"EARLY_PHASE1","title":"Pilot Trial of Chemohormonal Therapy Followed by Prostatectomy in High Risk Prostate Cancer","status":"COMPLETED","sponsor":"University of Wisconsin, Madison","startDate":"2018-01-17","conditions":"Prostate Cancer","enrollment":30},{"nctId":"NCT05412277","phase":"NA","title":"VIA Disc Nucleus Pulposus Older Patients Pilot","status":"ACTIVE_NOT_RECRUITING","sponsor":"VIVEX Biologics, Inc.","startDate":"2022-10-17","conditions":"Degenerative Disc Disease, Low Back Pain, Disc Degeneration","enrollment":21},{"nctId":"NCT05201287","phase":"NA","title":"VIA Disc NP Pilot for Patients With Symptomatic Degenerated Discs","status":"ACTIVE_NOT_RECRUITING","sponsor":"VIVEX Biologics, Inc.","startDate":"2021-12-30","conditions":"Degenerative Disc Disease, Low Back Pain, Disc Degeneration","enrollment":35},{"nctId":"NCT05338463","phase":"PHASE4","title":"Fespixon Cream for the Treatment of Chronic Diabetic Foot Ulcers (TEXAS 1A, 2A) in Dialysis Patients","status":"COMPLETED","sponsor":"Cathay General Hospital","startDate":"2021-12-01","conditions":"Chronic Diabetic Foot Ulcer","enrollment":5},{"nctId":"NCT06341595","phase":"PHASE2","title":"Concurrent Chemoradiotherapy Combined With Sintilimab as Neoadjuvant Therapy for GC Patients With PALM","status":"RECRUITING","sponsor":"The First Affiliated Hospital with Nanjing Medical University","startDate":"2024-04-01","conditions":"Gastric Cancer, Gastric Cancer Metastatic to Regional Lymph Nodes","enrollment":40}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":28,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["S-1"],"phase":"phase_3","status":"active","brandName":"S-1 single","genericName":"S-1 single","companyName":"Sun Yat-sen University","companyId":"sun-yat-sen-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"S-1 is an oral combination chemotherapy agent that inhibits thymidylate synthase and other folate metabolism enzymes to disrupt DNA synthesis in cancer cells. Used for Gastric cancer, Colorectal cancer, Pancreatic cancer.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}