{"id":"s-1","safety":{"commonSideEffects":[{"rate":"30–50%","effect":"Nausea and vomiting"},{"rate":"20–40%","effect":"Diarrhea"},{"rate":"20–30%","effect":"Anorexia"},{"rate":"20–30%","effect":"Fatigue"},{"rate":"10–25%","effect":"Bone marrow suppression (leukopenia, thrombocytopenia)"},{"rate":"5–15%","effect":"Hand-foot syndrome"},{"rate":"5–10%","effect":"Stomatitis"}]},"_chembl":null,"_dailymed":{"setId":"7be4d4f0-d1f3-468a-9a04-b9742cc16790","title":"FS-106 S PRAY (CHLORHEXIDINE GLUCONATE) SOLUTION [IBA]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"S-1 combines three components: tegafur (a prodrug of fluorouracil), gimeracil (an inhibitor of dihydropyrimidine dehydrogenase that prolongs fluorouracil half-life), and oteracil potassium (which reduces gastrointestinal toxicity). Together, these enhance and stabilize fluorouracil-mediated inhibition of thymidylate synthase, a key enzyme in DNA synthesis, leading to cancer cell death.","oneSentence":"S-1 is an oral combination of tegafur, gimeracil, and oteracil potassium that inhibits thymidylate synthase and enhances fluorouracil activity to suppress cancer cell DNA synthesis.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:37:26.690Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Gastric cancer"},{"name":"Colorectal cancer"},{"name":"Pancreatic cancer"},{"name":"Biliary tract cancer"}]},"trialDetails":[{"nctId":"NCT07495501","phase":"","title":"Patient Satisfaction During Lomber Transforaminal Epidural Steroid Injection: The Role of Sedation, Anxiety, and Pain","status":"NOT_YET_RECRUITING","sponsor":"Mersin University","startDate":"2026-04-01","conditions":"Lumbar Disc Disease, Radiculopathy Lumbar, Radicular 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