{"id":"rutin-vitamin-c","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dizziness"}]},"_chembl":null,"_dailymed":{"setId":"8bf57652-5750-4111-acef-45c5fdc676af","title":"SKINUVA BRUISE (ARNICA MONTANA, BROMELAIN, GRAPE SEED EXTRACT, VITAMIN C, RUTIN, ZINC OXIDE, CELLULOSE) CAPSULE [MD MEDICAL DESIGNS, INC.]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Rutin is a bioflavonoid that acts as a potent antioxidant and strengthens capillary walls by stabilizing collagen and reducing vascular permeability. Vitamin C (ascorbic acid) enhances this effect by regenerating rutin's antioxidant capacity and serving as a cofactor for collagen synthesis. Together, they reduce oxidative damage and improve microvascular function.","oneSentence":"Rutin and Vitamin C work synergistically as antioxidants to reduce oxidative stress and strengthen vascular integrity through free radical scavenging and collagen stabilization.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T02:49:21.784Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Venous insufficiency and capillary fragility"},{"name":"Hemorrhoids"},{"name":"Varicose veins"},{"name":"General antioxidant support"}]},"trialDetails":[{"nctId":"NCT07310407","phase":"PHASE2","title":"Rutin and Vitamin C in Patients With Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD)","status":"NOT_YET_RECRUITING","sponsor":"Ain Shams University","startDate":"2026-01-01","conditions":"NAFLD","enrollment":120},{"nctId":"NCT06271135","phase":"NA","title":"Assessing the Quality of Life of Patients With Rosacea","status":"COMPLETED","sponsor":"Medical University of Bialystok","startDate":"2017-05-08","conditions":"Rosacea","enrollment":160},{"nctId":"NCT04955145","phase":"PHASE3","title":"Evaluation of The Effect of Rutin and Vitamin C on the Oxidative Stress in Hemodialysis Patients","status":"UNKNOWN","sponsor":"Ain Shams University","startDate":"2021-06-20","conditions":"End Stage Renal Disease","enrollment":105},{"nctId":"NCT03437902","phase":"PHASE2, PHASE3","title":"Impact of Rutin and Vitamin C Combination on Oxidative Stress, Insulin Sensitivity and Lipid Profile in Type 2 Diabetic Patients","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2018-02-24","conditions":"Type 2 Diabetes Mellitus","enrollment":53}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":194,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Ruta C"],"phase":"marketed","status":"active","brandName":"Rutin + Vitamin C","genericName":"Rutin + Vitamin C","companyName":"Ain Shams University","companyId":"ain-shams-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Rutin and Vitamin C work synergistically as antioxidants to reduce oxidative stress and strengthen vascular integrity through free radical scavenging and collagen stabilization. Used for Venous insufficiency and capillary fragility, Hemorrhoids, Varicose veins.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}