{"id":"rsi-succinylcholine","safety":{"commonSideEffects":[{"rate":null,"effect":"Hyperkalemia"},{"rate":null,"effect":"Malignant hyperthermia"},{"rate":null,"effect":"Muscle fasciculations and postoperative myalgia"},{"rate":null,"effect":"Bradycardia"},{"rate":null,"effect":"Increased intracranial pressure"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Succinylcholine mimics acetylcholine and binds to nicotinic receptors on the motor end plate, causing initial depolarization and visible fasciculations followed by sustained depolarization that prevents repolarization and muscle contraction. This results in rapid onset paralysis lasting several minutes, making it useful for rapid sequence intubation and short procedures. The drug is metabolized by plasma cholinesterase, allowing for relatively quick recovery.","oneSentence":"Succinylcholine is a depolarizing neuromuscular blocking agent that binds to acetylcholine receptors at the neuromuscular junction, causing sustained depolarization and muscle paralysis.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:06:20.936Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Rapid sequence intubation and anesthesia induction"},{"name":"Short surgical procedures requiring muscle relaxation"},{"name":"Emergency airway management"}]},"trialDetails":[{"nctId":"NCT07428434","phase":"NA","title":"Which Rapid Sequence Induction Technique Should be Used in Urgent Surgery in Children?","status":"NOT_YET_RECRUITING","sponsor":"Tunis University","startDate":"2026-03-01","conditions":"Rapid Sequence Induction (RSI), Full Stomach, Pediatric","enrollment":100},{"nctId":"NCT05539391","phase":"NA","title":"Optimisation Strategy for Emergency Tracheal Intubation","status":"RECRUITING","sponsor":"University Hospital, Bordeaux","startDate":"2023-01-14","conditions":"Emergencies, Out-of-hospital Setting, Tracheal Intubation","enrollment":1500},{"nctId":"NCT06029049","phase":"PHASE4","title":"Comparison of Intubation Conditions During Rapid Sequence Induction Obtained With Modified Time Principal Induction With a Standard Intubation Dose of Rocuronium Versus Succinylcholine","status":"RECRUITING","sponsor":"The University of Texas Health Science Center, Houston","startDate":"2023-09-13","conditions":"Anesthesia","enrollment":152},{"nctId":"NCT01474252","phase":"PHASE4","title":"Comparison of Intubation Duration Between Rapid Sequence Intubation (RSI) Technique and Non-RSI Technique","status":"COMPLETED","sponsor":"Siriraj Hospital","startDate":"2008-07","conditions":"Tracheal Intubation Morbidity","enrollment":224},{"nctId":"NCT00462644","phase":"NA","title":"Evaluation of Etomidate on Adrenal Function in Trauma Patients","status":"COMPLETED","sponsor":"University of Tennessee","startDate":"2006-02","conditions":"Adrenal Insufficiency","enrollment":30}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":95,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"RSI succinylcholine","genericName":"RSI succinylcholine","companyName":"The University of Texas Health Science Center, Houston","companyId":"the-university-of-texas-health-science-center-houston","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Succinylcholine is a depolarizing neuromuscular blocking agent that binds to acetylcholine receptors at the neuromuscular junction, causing sustained depolarization and muscle paralysis. Used for Rapid sequence intubation and anesthesia induction, Short surgical procedures requiring muscle relaxation, Emergency airway management.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}