{"id":"routine-paediatric-vaccine-hepatitis-a","safety":{"commonSideEffects":[{"rate":"10–30","effect":"Injection site pain, erythema, or swelling"},{"rate":"5–15","effect":"Fever"},{"rate":"5–10","effect":"Headache"},{"rate":"5–10","effect":"Fatigue"},{"rate":"3–8","effect":"Loss of appetite"}]},"_chembl":{"chemblId":"CHEMBL2109163","moleculeType":"Vaccine component"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The vaccine contains inactivated hepatitis A virus antigen that triggers both humoral (antibody) and cellular immune responses. This leads to the production of anti-HAV antibodies that neutralize the virus upon exposure, preventing infection and disease. The vaccine is typically given as a two-dose series to establish long-term immunity.","oneSentence":"Hepatitis A vaccine stimulates the immune system to produce antibodies against hepatitis A virus, providing protection against infection.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:32:53.289Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of hepatitis A infection in pediatric patients"}]},"trialDetails":[{"nctId":"NCT02482636","phase":"PHASE2","title":"Baby Vaccine Study (Sched3)","status":"COMPLETED","sponsor":"University of Oxford","startDate":"2015-08","conditions":"Infectious Diseases","enrollment":189},{"nctId":"NCT00483574","phase":"PHASE3","title":"Study of the Safety of Menactra® Vaccine When Administered With Other Pediatric Vaccines to Healthy Toddlers","status":"COMPLETED","sponsor":"Sanofi Pasteur, a Sanofi Company","startDate":"2007-05","conditions":"Meningococcal Meningitis, Measles, Mumps","enrollment":1378}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Hepatitis A"],"phase":"phase_3","status":"active","brandName":"Routine paediatric vaccine - Hepatitis A","genericName":"Routine paediatric vaccine - Hepatitis A","companyName":"Sanofi Pasteur, a Sanofi Company","companyId":"sanofi","modality":"Biologic","firstApprovalDate":"","aiSummary":"Hepatitis A vaccine stimulates the immune system to produce antibodies against hepatitis A virus, providing protection against infection. Used for Prevention of hepatitis A infection in pediatric patients.","enrichmentLevel":3,"visitCount":2,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}