{"id":"rotateq-existing-formulation","safety":{"commonSideEffects":[{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Vomiting"},{"rate":null,"effect":"Fever"},{"rate":null,"effect":"Irritability"}]},"_chembl":{"chemblId":"CHEMBL6068358","moleculeType":"Vaccine component"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"RotaTeq contains five live reassortant rotavirus strains (derived from human and bovine rotavirus parents) that replicate in the intestinal tract and induce both humoral and mucosal immunity against rotavirus. The vaccine generates antibodies and cellular immune responses that protect against infection by wild-type rotavirus strains, preventing severe diarrheal disease in infants and young children.","oneSentence":"RotaTeq is a live attenuated rotavirus vaccine that stimulates immune responses to prevent rotavirus gastroenteritis.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:32:52.777Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of rotavirus gastroenteritis in infants and children"}]},"trialDetails":[{"nctId":"NCT01600092","phase":"PHASE3","title":"A Study of the Immunogenicity, Tolerability, and Safety of a New Formulation of RotaTeq™ in Infants (V260-035)","status":"COMPLETED","sponsor":"Merck Sharp & Dohme LLC","startDate":"2013-04-29","conditions":"Rotavirus Gastroenteritis","enrollment":1020}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["V260"],"phase":"phase_3","status":"active","brandName":"RotaTeq™ existing formulation","genericName":"RotaTeq™ existing formulation","companyName":"Merck Sharp & Dohme LLC","companyId":"merck-sharp-dohme-llc","modality":"Biologic","firstApprovalDate":"","aiSummary":"RotaTeq is a live attenuated rotavirus vaccine that stimulates immune responses to prevent rotavirus gastroenteritis. Used for Prevention of rotavirus gastroenteritis in infants and children.","enrichmentLevel":3,"visitCount":2,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}