{"id":"rosuvastatin-ranitidine","safety":{"commonSideEffects":[{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Myalgia"},{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Elevated liver enzymes"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Rosuvastatin inhibits HMG-CoA reductase to reduce LDL cholesterol and cardiovascular risk, while ranitidine blocks histamine H2 receptors on gastric parietal cells to reduce acid secretion. The combination is designed to provide cardiovascular protection while mitigating gastrointestinal side effects that may occur with statin monotherapy.","oneSentence":"This is a fixed-dose combination of rosuvastatin (a statin that lowers cholesterol) and ranitidine (an H2-receptor antagonist that reduces stomach acid).","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:06:16.606Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypercholesterolemia with gastrointestinal intolerance or risk"}]},"trialDetails":[{"nctId":"NCT00930670","phase":"PHASE4","title":"Evaluation of the Influence of Statins and Proton Pump Inhibitors on Clopidogrel Antiplatelet Effects","status":"COMPLETED","sponsor":"Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec","startDate":"2009-06","conditions":"Coronary Artery Disease","enrollment":320}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Rosuvastatin-ranitidine","genericName":"Rosuvastatin-ranitidine","companyName":"Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec","companyId":"centre-de-recherche-de-l-institut-universitaire-de-cardiologie-et-de-pneumologie","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Rosuvastatin is a statin used to treat coronary artery disease, and it is often combined with other medications. Ranitidine, a histamine H2 receptor antagonist, is a small molecule that works by blocking the histamine H2 receptor, which is involved in stomach acid production.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}