{"id":"ropivacine-and-chloroprocaine-mixture","safety":{"commonSideEffects":[{"rate":null,"effect":"Systemic toxicity (CNS effects: tremor, seizure)"},{"rate":null,"effect":"Cardiovascular effects (hypotension, arrhythmia)"},{"rate":null,"effect":"Allergic reactions"},{"rate":null,"effect":"Local tissue irritation or necrosis"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Ropivacaine and chloroprocaine are both amide and ester local anesthetics, respectively, that work by inhibiting sodium influx through voltage-gated sodium channels in nerve cell membranes. This prevents depolarization and propagation of action potentials, thereby blocking pain sensation in the infiltrated tissue. The combination may provide complementary pharmacokinetic profiles, with chloroprocaine offering rapid onset and ropivacaine providing longer duration.","oneSentence":"This mixture of two local anesthetics blocks sodium channels in nerve fibers to prevent pain signal transmission.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:06:03.839Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Local and regional anesthesia"}]},"trialDetails":[{"nctId":"NCT01719237","phase":"PHASE4","title":"Trial Comparing the Onset and Duration of Ultrasound Guided Supraclavicular Nerve Blocks Using Ropivacaine Versus Ropivacaine-Chloroprocaine Mixture","status":"COMPLETED","sponsor":"University of New Mexico","startDate":"2009-08","conditions":"Pain","enrollment":60}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Ropivacine and Chloroprocaine mixture","genericName":"Ropivacine and Chloroprocaine mixture","companyName":"University of New Mexico","companyId":"university-of-new-mexico","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This mixture of two local anesthetics blocks sodium channels in nerve fibers to prevent pain signal transmission. Used for Local and regional anesthesia.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}