{"id":"ropivacaine-ketorelac-and-epinephrine","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Nausea"},{"rate":"5-10%","effect":"Vomiting"},{"rate":"5-10%","effect":"Dizziness"},{"rate":"5-10%","effect":"Headache"},{"rate":"5-10%","effect":"Hypertension"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Ropivacaine works by inhibiting the sodium channels in nerve fibers, which prevents the transmission of pain signals to the brain. Ketorolac, on the other hand, blocks the production of prostaglandins, which are chemical mediators of pain and inflammation. Epinephrine helps to constrict blood vessels, which reduces bleeding and prolongs the duration of action of ropivacaine.","oneSentence":"Ropivacaine is a local anesthetic that blocks nerve impulses, while ketorolac is a nonsteroidal anti-inflammatory drug (NSAID) that reduces pain and inflammation, and epinephrine is a vasoconstrictor that helps to prolong the duration of action of ropivacaine.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:32:42.236Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Postoperative pain management"},{"name":"Pain management during labor and delivery"}]},"trialDetails":[{"nctId":"NCT01782781","phase":"PHASE3","title":"Local Infiltration Analgesia After Abdominal Hysterectomy","status":"COMPLETED","sponsor":"Göteborg University","startDate":"2012-11","conditions":"Pain","enrollment":60},{"nctId":"NCT00653926","phase":"NA","title":"Local Infiltration Analgesia Following Unicompartmental Knee Arthroplasty","status":"COMPLETED","sponsor":"Region Örebro County","startDate":"2005-09","conditions":"Postoperative Pain","enrollment":40}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Narop, Toradol and adrenaline"],"phase":"phase_3","status":"active","brandName":"ropivacaine, ketorelac and epinephrine","genericName":"ropivacaine, ketorelac and epinephrine","companyName":"Region Örebro County","companyId":"region-rebro-county","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ropivacaine is a local anesthetic that blocks nerve impulses, while ketorolac is a nonsteroidal anti-inflammatory drug (NSAID) that reduces pain and inflammation, and epinephrine is a vasoconstrictor that helps to prolong the duration of action of ropivacaine. Used for Postoperative pain management, Pain management during labor and delivery.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}