{"id":"ropivacaine-hydrocloride","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Bradycardia"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Neurological toxicity (at high doses)"}]},"_chembl":{"chemblId":"CHEMBL1077896","moleculeType":"Small molecule","molecularWeight":"274.41"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"As an amide-type local anesthetic, ropivacaine selectively inhibits sodium influx into nerve fibers, which stabilizes the neuronal membrane and prevents depolarization. This action reversibly blocks pain signal transmission along peripheral nerves. Ropivacaine is structurally similar to bupivacaine but has a lower propensity for cardiotoxicity and central nervous system toxicity.","oneSentence":"Ropivacaine hydrochloride is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:37:18.268Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Local and regional anesthesia for surgical procedures"},{"name":"Acute pain management via peripheral nerve blocks"},{"name":"Epidural anesthesia"}]},"trialDetails":[{"nctId":"NCT07449442","phase":"NA","title":"SII Levels Following iPACK Block With Adductor Canal Block in Knee Arthroplasty","status":"NOT_YET_RECRUITING","sponsor":"Poznan University of Medical Sciences","startDate":"2026-04-01","conditions":"Knee Osteoarthritis","enrollment":60},{"nctId":"NCT06094946","phase":"","title":"Parturient Satisfaction With Epidural Analgesia by PCEA or Manual Boluses","status":"NOT_YET_RECRUITING","sponsor":"Women's Hospital HUS","startDate":"2024-12","conditions":"Labor Pain","enrollment":100},{"nctId":"NCT03339284","phase":"PHASE4","title":"QLB and Laparoscopic Nephrectomy, Postoperative Pain and Recovery","status":"UNKNOWN","sponsor":"Tampere University Hospital","startDate":"2017-12-04","conditions":"Postoperative Pain, Chronic Pain Post-Proceduraal, Nausea and Vomiting, Postoperative","enrollment":90}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["0.2% ropivacaine"],"phase":"marketed","status":"active","brandName":"Ropivacaine Hydrocloride","genericName":"Ropivacaine Hydrocloride","companyName":"Women's Hospital HUS","companyId":"women-s-hospital-hus","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ropivacaine hydrochloride is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. Used for Local and regional anesthesia for surgical procedures, Acute pain management via peripheral nerve blocks, Epidural anesthesia.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}