{"id":"ropivacaine-0-75-in-peng-block","safety":{"commonSideEffects":[{"rate":null,"effect":"Transient neurological symptoms"},{"rate":null,"effect":"Systemic toxicity (CNS and cardiac)"},{"rate":null,"effect":"Local tissue irritation"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Bradycardia"}]},"_chembl":{"chemblId":"CHEMBL1077896","moleculeType":"Small molecule","molecularWeight":"274.41"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Ropivacaine is an amide-type local anesthetic that reversibly inhibits sodium influx through voltage-gated sodium channels in nerve cell membranes. By blocking sodium channel conductance, it prevents depolarization and action potential generation in sensory and motor nerves. The PENG (Pectineus Fascia Iliopsoas Nerve Groove) block is a regional anesthesia technique that delivers ropivacaine to anesthetize the femoral nerve and its branches for lower limb anesthesia and analgesia.","oneSentence":"Ropivacaine is a local anesthetic that blocks sodium channels in nerve fibers, preventing the initiation and propagation of action potentials to produce regional anesthesia.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:05:42.721Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Regional anesthesia via PENG block for lower limb surgery and postoperative analgesia"}]},"trialDetails":[],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Ropivacaine 0,75% in PENG block","genericName":"Ropivacaine 0,75% in PENG block","companyName":"University of Liege","companyId":"university-of-liege","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ropivacaine is a local anesthetic that blocks sodium channels in nerve fibers, preventing the initiation and propagation of action potentials to produce regional anesthesia. Used for Regional anesthesia via PENG block for lower limb surgery and postoperative analgesia.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}