{"id":"ropivacaine-0-2-for-s-espb","safety":{"commonSideEffects":[{"rate":null,"effect":"Systemic toxicity (CNS effects: dizziness, tinnitus, seizures)"},{"rate":null,"effect":"Cardiovascular effects (hypotension, bradycardia, arrhythmias)"},{"rate":null,"effect":"Local tissue irritation or injection site reactions"},{"rate":"rare","effect":"Allergic reactions"}]},"_chembl":{"chemblId":"CHEMBL1077896","moleculeType":"Small molecule","molecularWeight":"274.41"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Ropivacaine is an amide-type local anesthetic that reversibly inhibits sodium influx through voltage-gated sodium channels in nerve cell membranes. This prevents depolarization and action potential generation in sensory and motor nerves. When administered via serratus anterior plane block (S-ESPB), it provides regional anesthesia to the chest wall and surrounding structures.","oneSentence":"Ropivacaine is a local anesthetic that blocks sodium channels in nerve fibers, preventing the initiation and propagation of action potentials to produce regional anesthesia.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:05:41.059Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Regional anesthesia via serratus anterior plane block (S-ESPB) for chest wall procedures and pain management"}]},"trialDetails":[{"nctId":"NCT07288983","phase":"NA","title":"PENG Block vs Suprainguinal FICB vs Lumbar ESPB for Analgesia After Hip Surgery","status":"RECRUITING","sponsor":"Poznan University of Medical Sciences","startDate":"2026-02-06","conditions":"Hip Osteoarthritis","enrollment":93},{"nctId":"NCT07288970","phase":"NA","title":"ACB With S-ESPB Versus ACB With iPACK for Knee Arthroplasty","status":"RECRUITING","sponsor":"Poznan University of Medical Sciences","startDate":"2025-12-25","conditions":"Knee Osteoarthritis","enrollment":80},{"nctId":"NCT07180979","phase":"PHASE4","title":"PENG vs L-ESPB With S-ESPB for Analgesia in Total Hip Arthroplasty","status":"NOT_YET_RECRUITING","sponsor":"Poznan University of Medical Sciences","startDate":"2026-03-01","conditions":"Hip Osteoarthritis, Hip Arthropathy, Hip Pain Chronic","enrollment":90},{"nctId":"NCT07023094","phase":"PHASE4","title":"PENG With LFCB vs. ESP Blocks for Pediatric Hip Surgery","status":"RECRUITING","sponsor":"Poznan University of Medical Sciences","startDate":"2025-06-16","conditions":"Hip Disease, Hip Dysplasia, Hip Arthropathy","enrollment":60}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Ropivacaine 0.2% for S-ESPB","genericName":"Ropivacaine 0.2% for S-ESPB","companyName":"Poznan University of Medical Sciences","companyId":"poznan-university-of-medical-sciences","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ropivacaine is a local anesthetic that blocks sodium channels in nerve fibers, preventing the initiation and propagation of action potentials to produce regional anesthesia. Used for Regional anesthesia via serratus anterior plane block (S-ESPB) for chest wall procedures and pain management.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}