{"id":"ropivacaine-0-2-for-lfcb","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site reactions (pain, erythema)"},{"rate":null,"effect":"Systemic toxicity (CNS effects: dizziness, tinnitus, seizures)"},{"rate":null,"effect":"Cardiovascular effects (hypotension, bradycardia, arrhythmias)"},{"rate":"rare","effect":"Allergic reactions"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Ropivacaine is an amide-type local anesthetic that reversibly inhibits sodium influx through voltage-gated sodium channels in nerve fibers, thereby preventing depolarization and nerve impulse transmission. This results in local loss of sensation in the area where it is administered. The 0.2% concentration is a dilute formulation suitable for infiltration and regional anesthesia techniques.","oneSentence":"Ropivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:05:49.743Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Local infiltration anesthesia"},{"name":"Regional anesthesia (nerve blocks, epidural, peripheral nerve blocks)"}]},"trialDetails":[{"nctId":"NCT07023094","phase":"PHASE4","title":"PENG With LFCB vs. ESP Blocks for Pediatric Hip Surgery","status":"RECRUITING","sponsor":"Poznan University of Medical Sciences","startDate":"2025-06-16","conditions":"Hip Disease, Hip Dysplasia, Hip Arthropathy","enrollment":60}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Ropivacaine 0.2% for LFCB","genericName":"Ropivacaine 0.2% for LFCB","companyName":"Poznan University of Medical Sciences","companyId":"poznan-university-of-medical-sciences","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ropivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials. Used for Local infiltration anesthesia, Regional anesthesia (nerve blocks, epidural, peripheral nerve blocks).","enrichmentLevel":3,"visitCount":2,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}