{"id":"ropivacaine-0-2-for-l-espb","safety":{"commonSideEffects":[{"rate":null,"effect":"Systemic toxicity (CNS effects: dizziness, tinnitus, seizures)"},{"rate":null,"effect":"Cardiovascular effects (hypotension, bradycardia)"},{"rate":null,"effect":"Local tissue irritation or infection at injection site"},{"rate":null,"effect":"Transient nerve injury"}]},"_chembl":{"chemblId":"CHEMBL1077896","moleculeType":"Small molecule","molecularWeight":"274.41"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Ropivacaine is an amide-type local anesthetic that reversibly inhibits sodium influx through voltage-gated sodium channels in nerve cell membranes. This prevents depolarization and action potential generation in sensory and motor nerves. When administered via L-ESPB (Lateral Erector Spinae Plane Block), it provides regional anesthesia to the thoracic and abdominal wall by blocking nerve conduction in the relevant dermatomes.","oneSentence":"Ropivacaine is a local anesthetic that blocks sodium channels in nerve fibers, preventing the initiation and propagation of action potentials to produce regional anesthesia.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:05:39.645Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Regional anesthesia via lateral erector spinae plane block for thoracic and abdominal wall anesthesia"}]},"trialDetails":[{"nctId":"NCT07288983","phase":"NA","title":"PENG Block vs Suprainguinal FICB vs Lumbar ESPB for Analgesia After Hip Surgery","status":"RECRUITING","sponsor":"Poznan University of Medical Sciences","startDate":"2026-02-06","conditions":"Hip Osteoarthritis","enrollment":93},{"nctId":"NCT07180979","phase":"PHASE4","title":"PENG vs L-ESPB With S-ESPB for Analgesia in Total Hip Arthroplasty","status":"NOT_YET_RECRUITING","sponsor":"Poznan University of Medical Sciences","startDate":"2026-03-01","conditions":"Hip Osteoarthritis, Hip Arthropathy, Hip Pain Chronic","enrollment":90},{"nctId":"NCT07023094","phase":"PHASE4","title":"PENG With LFCB vs. ESP Blocks for Pediatric Hip Surgery","status":"RECRUITING","sponsor":"Poznan University of Medical Sciences","startDate":"2025-06-16","conditions":"Hip Disease, Hip Dysplasia, Hip Arthropathy","enrollment":60}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Ropivacaine 0.2% for L-ESPB","genericName":"Ropivacaine 0.2% for L-ESPB","companyName":"Poznan University of Medical Sciences","companyId":"poznan-university-of-medical-sciences","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ropivacaine is a local anesthetic that blocks sodium channels in nerve fibers, preventing the initiation and propagation of action potentials to produce regional anesthesia. Used for Regional anesthesia via lateral erector spinae plane block for thoracic and abdominal wall anesthesia.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}