{"id":"rocuronium-0-8","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Hypotension"},{"rate":"5-10%","effect":"Bradycardia"},{"rate":"5-10%","effect":"Respiratory depression"},{"rate":"0.1-1%","effect":"Anaphylaxis"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"This inhibition prevents acetylcholine from binding to its receptor, leading to muscle paralysis. The effect is reversible with anticholinesterases or by allowing time for spontaneous recovery.","oneSentence":"Rocuronium is a non-depolarizing neuromuscular blocking agent that competitively inhibits nicotinic acetylcholine receptors at the neuromuscular junction.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:52:28.457Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Endotracheal intubation"},{"name":"Surgical procedures requiring muscle relaxation"}]},"trialDetails":[{"nctId":"NCT05881291","phase":"PHASE4","title":"Efficacy and Safety of Ciprofol for General Anaesthesia in Patients Undergoing Transcatheter Aortic Valve Replacement","status":"COMPLETED","sponsor":"Second Affiliated Hospital, School of Medicine, Zhejiang University","startDate":"2023-06-29","conditions":"Hemodynamics, Transcatheter Aortic Valve Replacement, General Anesthesia","enrollment":124},{"nctId":"NCT06183567","phase":"NA","title":"The Effect of Sedoanalgesia and General Anaesthesia on Early Neurological Recovery in Acute Ischaemic Stroke Patients Undergoing Endovascular Thrombectomy","status":"ACTIVE_NOT_RECRUITING","sponsor":"Umraniye Education and Research Hospital","startDate":"2023-11-30","conditions":"Ischemic Stroke, Anesthesia, Neurologic Symptoms","enrollment":62},{"nctId":"NCT05864625","phase":"NA","title":"Comparison of Hemodynamic Stability During Anesthesia Using Remimazolam and Sevoflurane in Minimally Invasive AVR","status":"COMPLETED","sponsor":"Pusan National University Yangsan Hospital","startDate":"2023-06-29","conditions":"Aortic Valve Stenosis, Remimazolam","enrollment":64},{"nctId":"NCT07084753","phase":"NA","title":"Non-opioid Anesthesia Based on Thoracic Paravertebral Block During Laparoscopic Sleeve Gastrectomy","status":"NOT_YET_RECRUITING","sponsor":"IVO JURISIC","startDate":"2025-07-30","conditions":"Obese Patients, Bariatric Surgical Pain, Bariatric Surgery (Sleeve Gastrectomy )","enrollment":36},{"nctId":"NCT05816538","phase":"NA","title":"The Immune Response of Breast Cancer Patients Treated With Levobupivacaine Using Paravertebral or Superficial Chest Blocks","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of Rijeka","startDate":"2024-01-18","conditions":"Paravertebral Block, Pectoralis and Serratus Plane Nerve Blocks, Breast Cancer","enrollment":100},{"nctId":"NCT06764667","phase":"NA","title":"Comparison of Spinal Anesthesia Adjuvant and Quadratus Lumborum Block on the Opioid Requirement and Perioperative Pain of Laparoscopic Kidney Transplant Donor","status":"RECRUITING","sponsor":"Indonesia University","startDate":"2025-02-10","conditions":"Laparoscopic Donor Nephrectomy, Perioperative Pain Management","enrollment":60},{"nctId":"NCT05725031","phase":"PHASE3","title":"Intubation Conditions After RSI Using Rocuronium with Ephedrine Pretreatment","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2023-04-01","conditions":"Rapid Sequence Induction and Intubation","enrollment":75},{"nctId":"NCT05772260","phase":"","title":"Autonomic Dysfunction and Hemodynamic Instability During Per-oral Endoscopic Myotomy","status":"RECRUITING","sponsor":"Gangnam Severance Hospital","startDate":"2023-04-03","conditions":"Achalasia","enrollment":40},{"nctId":"NCT06238830","phase":"","title":"Evaluation of Multimodal Analgesia With NOL","status":"UNKNOWN","sponsor":"Ankara City Hospital Bilkent","startDate":"2024-02-01","conditions":"Pain, Postoperative, Analgesia","enrollment":80},{"nctId":"NCT04817943","phase":"","title":"Comparison of Esophageal and Tracheal Temperature in the Patients Using Breathing Circuit With Heated Wire Humidifier","status":"COMPLETED","sponsor":"Pusan National University Yangsan Hospital","startDate":"2021-04-29","conditions":"The Patients Who Underwent General Anesthesia","enrollment":38},{"nctId":"NCT05617690","phase":"NA","title":"Cyclopol on Electrophysiological Monitoring During Spine Surgery: a Randomized Controlled, Noninferiority Study","status":"UNKNOWN","sponsor":"Beijing Tiantan Hospital","startDate":"2023-04-04","conditions":"Visual Evoked Potentials","enrollment":148},{"nctId":"NCT05322902","phase":"NA","title":"Remimazolam Total Intravenous Anesthesia Under Analgesia Nociception Index-guidance","status":"COMPLETED","sponsor":"Gangnam Severance Hospital","startDate":"2022-06-02","conditions":"Knee Osteoarthritis, Total Knee Arthroplasty, Remimazolam","enrollment":84},{"nctId":"NCT03317535","phase":"NA","title":"Choice of Anesthesia for Endovascular Treatment of Acute Ischemic Stroke in Posterior Circulation","status":"COMPLETED","sponsor":"Beijing Tiantan Hospital","startDate":"2018-03-18","conditions":"Posterior Circulation Brain Infarction","enrollment":93},{"nctId":"NCT04529135","phase":"NA","title":"The Effect of Dexmedetomidine During Opioid Free Anesthesia on Postoperative Recovery After Gastrectomy","status":"COMPLETED","sponsor":"Gangnam Severance Hospital","startDate":"2020-08-26","conditions":"Gastric Cancer","enrollment":68},{"nctId":"NCT05425069","phase":"","title":"Evaluation of the EEG Connectivity Using Predominant Dexmedetomidine as Anesthetic in Fragile Brains","status":"UNKNOWN","sponsor":"Universidad del Desarrollo","startDate":"2022-01-02","conditions":"Aging Problems","enrollment":24},{"nctId":"NCT04780490","phase":"NA","title":"Comparison of Liberal and Restrictive Fluid Management on the Endothelial Glycocalyx in Radical Cystectomy","status":"COMPLETED","sponsor":"Istanbul University","startDate":"2018-03-01","conditions":"Fluid Retention Tissue","enrollment":37},{"nctId":"NCT04767256","phase":"NA","title":"Intravenous Dexamethasone and Dexmedetomidine on the Analgesic Efficacy of Erector Spinae Plane Block","status":"COMPLETED","sponsor":"Huazhong University of Science and Technology","startDate":"2021-03-01","conditions":"Dexamethasone, Dexmedetomidine, Nerve Block","enrollment":120},{"nctId":"NCT05097508","phase":"EARLY_PHASE1","title":"Effect of Atracurium and Rocuronium on the State and Response Entropy During Isoflurane Anesthesia","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2020-06-20","conditions":"Entropy Device and How Will Muscle Relaxants Affect it","enrollment":40},{"nctId":"NCT04271462","phase":"","title":"The Influence of Two Different CO2 Absorbers on Sevoflurane Consumption During Anaesthesia","status":"COMPLETED","sponsor":"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)","startDate":"2020-02-12","conditions":"Anesthesia","enrollment":38},{"nctId":"NCT03266419","phase":"NA","title":"Effectiveness of Deep Versus Moderate Neuromuscular Blockade","status":"COMPLETED","sponsor":"Asan Medical Center","startDate":"2018-03-28","conditions":"Neuromuscular Blockade","enrollment":100},{"nctId":"NCT03157479","phase":"NA","title":"Intraoperative Protective Ventilation for Obese Patients Undergoing Gynaecological Laparoscopic Surgery","status":"COMPLETED","sponsor":"Catholic University of the Sacred Heart","startDate":"2017-05-01","conditions":"Anesthesia, Surgery--Complications","enrollment":60},{"nctId":"NCT00591786","phase":"PHASE2","title":"A Bridging Trial Comparing Sugammadex (Org 25969) at 1-2 Post-Tetanic Count (PTC) in Japanese Participants. Part A (P05957)","status":"COMPLETED","sponsor":"Merck Sharp & Dohme LLC","startDate":"2005-12-05","conditions":"Anesthesia, General","enrollment":100},{"nctId":"NCT01715584","phase":"PHASE4","title":"Is There an Adverse Drug Reaction Between Renin-Angiotensin System Blockade and Inhaled Anesthetics","status":"UNKNOWN","sponsor":"London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's","startDate":"2012-07","conditions":"Hypertension","enrollment":80},{"nctId":"NCT03095144","phase":"","title":"Spinal Anesthesia and General Anesthesia for Pyloromyotomy - Surgical Outcomes a Comparison Retrospective Study","status":"UNKNOWN","sponsor":"Bnai Zion Medical Center","startDate":"2017-05","conditions":"Hypertrophic Pyloric Stenosis, Spinal Anesthesia, General Anesthesia","enrollment":100},{"nctId":"NCT02709473","phase":"PHASE4","title":"The Effect of Propofol and Remifentanil Sequence on ED50 and ED95 of Rocuronium in Rapid Sequence Induction Anesthesia","status":"COMPLETED","sponsor":"Ankara University","startDate":"2016-03","conditions":"Anesthesia, Neuromuscular Blockade","enrollment":84},{"nctId":"NCT02134093","phase":"PHASE4","title":"Effects of Dexmedetomidine on Postoperative Cognitive Dysfunction During One-lung Ventilation in Elder Patients","status":"UNKNOWN","sponsor":"Tang-Du Hospital","startDate":"2014-07","conditions":"Postoperative Confusion","enrollment":120},{"nctId":"NCT01851005","phase":"NA","title":"Effect of Dexmedetomidine on Recovery Profiles of Elderly Patients","status":"COMPLETED","sponsor":"Chosun University Hospital","startDate":"2013-05","conditions":"Elderly Patients, Anesthesia, Emergence From Anesthesia","enrollment":120},{"nctId":"NCT01517932","phase":"PHASE4","title":"Effects of Dexmedetomidine on Stress Response and Postoperative Analgesia","status":"COMPLETED","sponsor":"Fang Luo","startDate":"2011-06","conditions":"Restlessness, Pain","enrollment":60}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":16,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Rocuronium 0.8","genericName":"Rocuronium 0.8","companyName":"Ain Shams University","companyId":"ain-shams-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Rocuronium is a non-depolarizing neuromuscular blocking agent that competitively inhibits nicotinic acetylcholine receptors at the neuromuscular junction. Used for Endotracheal intubation, Surgical procedures requiring muscle relaxation.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}