{"id":"ro7234292","safety":{"commonSideEffects":[{"rate":null,"effect":"Infusion-related reactions"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Vomiting"},{"rate":null,"effect":"Fatigue"},{"rate":null,"effect":"Diarrhea"}]},"_chembl":{"chemblId":"CHEMBL4297581","moleculeType":"Oligonucleotide"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"CLDN18.2 is a tight junction protein aberrantly expressed on the surface of gastric cancer and other malignancies. By binding to CLDN18.2, RO7234292 triggers antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP), leading to direct tumor cell killing. This mechanism allows the immune system to recognize and eliminate cancer cells expressing this antigen.","oneSentence":"RO7234292 is a monoclonal antibody that targets and inhibits Claudin 18.2 (CLDN18.2), a tumor-associated antigen expressed on gastric and other cancer cells.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:32:33.204Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Gastric cancer (gastric adenocarcinoma)"},{"name":"Gastroesophageal junction cancer"}]},"trialDetails":[{"nctId":"NCT05686551","phase":"PHASE2","title":"GENERATION HD2. A Study to Evaluate the Safety, Biomarkers, and Efficacy of Tominersen Compared With Placebo in Participants With Prodromal and Early Manifest Huntington's Disease","status":"ACTIVE_NOT_RECRUITING","sponsor":"Hoffmann-La Roche","startDate":"2023-02-03","conditions":"Huntington Disease","enrollment":301},{"nctId":"NCT04000594","phase":"PHASE1","title":"A Study to Investigate the Pharmacokinetics and Pharmacodynamics of RO7234292 (RG6042) in CSF and Plasma, and Safety and Tolerability Following Intrathecal Administration in Patients With Huntington's Disease","status":"COMPLETED","sponsor":"Hoffmann-La Roche","startDate":"2019-09-02","conditions":"Huntingtons Disease","enrollment":12},{"nctId":"NCT03761849","phase":"PHASE3","title":"A Study to Evaluate the Efficacy and Safety of Intrathecally Administered RO7234292 (RG6042) in Participants With Manifest Huntington's Disease","status":"COMPLETED","sponsor":"Hoffmann-La Roche","startDate":"2019-01-23","conditions":"Huntingtons Disease","enrollment":899},{"nctId":"NCT03842969","phase":"PHASE3","title":"An Open-Label Extension Study to Evaluate Long-Term Safety and Tolerability of RO7234292 (RG6042) in Huntington's Disease Participants Who Participated in Prior Roche and Genentech Sponsored Studies","status":"COMPLETED","sponsor":"Hoffmann-La Roche","startDate":"2019-04-23","conditions":"Huntington Disease","enrollment":236},{"nctId":"NCT03342053","phase":"PHASE2","title":"A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7234292 (ISIS 443139) in Huntington's Disease Patients Who Participated in Prior Investigational Studies of RO7234292 (ISIS 443139)","status":"COMPLETED","sponsor":"Hoffmann-La Roche","startDate":"2018-01-02","conditions":"Huntington's Disease","enrollment":46}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Tominersen"],"phase":"phase_3","status":"active","brandName":"RO7234292","genericName":"RO7234292","companyName":"Hoffmann-La Roche","companyId":"hoffmann-la-roche","modality":"Small molecule","firstApprovalDate":"","aiSummary":"RO7234292 is a monoclonal antibody that targets and inhibits Claudin 18.2 (CLDN18.2), a tumor-associated antigen expressed on gastric and other cancer cells. Used for Gastric cancer (gastric adenocarcinoma), Gastroesophageal junction cancer.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}