{"id":"rizatriptan-co-administered-with-acetaminophen","safety":{"commonSideEffects":[{"rate":"9-10","effect":"Dizziness"},{"rate":"7-8","effect":"Somnolence"},{"rate":"5-6","effect":"Asthenia/fatigue"},{"rate":"2-3","effect":"Chest pain/pressure"},{"rate":"2-3","effect":"Paresthesia"},{"rate":"3-5","effect":"Nausea"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Rizatriptan is a triptan that acts as a selective 5-HT1B/1D receptor agonist, causing vasoconstriction of dilated cranial blood vessels and reducing the release of inflammatory neuropeptides involved in migraine pathophysiology. Acetaminophen complements this mechanism by inhibiting prostaglandin synthesis, providing additive pain relief. The combination targets migraine through both vascular and analgesic pathways.","oneSentence":"Rizatriptan selectively binds to serotonin 5-HT1B/1D receptors to constrict cranial blood vessels and inhibit neuropeptide release, while acetaminophen provides additional analgesic and antipyretic effects through COX inhibition.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:32:31.218Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute migraine with or without aura"}]},"trialDetails":[{"nctId":"NCT00300924","phase":"PHASE3","title":"A Study of Rizatriptan Co-Administered With Acetaminophen for the Treatment of Acute Migraine","status":"COMPLETED","sponsor":"Diamond Headache Clinic","startDate":"2006-03","conditions":"Migraine","enrollment":200}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Rizatriptan co-administered with Acetaminophen","genericName":"Rizatriptan co-administered with Acetaminophen","companyName":"Diamond Headache Clinic","companyId":"diamond-headache-clinic","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Rizatriptan selectively binds to serotonin 5-HT1B/1D receptors to constrict cranial blood vessels and inhibit neuropeptide release, while acetaminophen provides additional analgesic and antipyretic effects through COX inhibition. Used for Acute migraine with or without aura.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}