{"id":"rivastigmine-prevention-of-delirium","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Nausea"},{"rate":"5-10%","effect":"Vomiting"},{"rate":"5-10%","effect":"Diarrhea"},{"rate":"5-10%","effect":"Fatigue"},{"rate":"5-10%","effect":"Headache"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"By inhibiting the enzyme acetylcholinesterase, rivastigmine allows acetylcholine to accumulate in the brain, stimulating cholinergic receptors and enhancing neurotransmission. This mechanism is thought to be beneficial in the treatment of Alzheimer's disease and other neurodegenerative disorders, including delirium prevention.","oneSentence":"Rivastigmine is a cholinesterase inhibitor that works by increasing the concentration of acetylcholine in the brain, which helps to improve cognitive function and prevent delirium.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:32:33.655Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of delirium"}]},"trialDetails":[{"nctId":"NCT04189666","phase":"PHASE1, PHASE2","title":"Rivastigmine Patch Compared to Melatonin Patch in Prevention of Postoperative Delirium","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2019-11-18","conditions":"Delirium","enrollment":180},{"nctId":"NCT00257868","phase":"PHASE3","title":"Rivastigmine for the Prevention of Postoperative Delirium in Patients Undergoing Cardiac Surgery","status":"COMPLETED","sponsor":"University Hospital, Basel, Switzerland","startDate":"2006-01","conditions":"Delirium","enrollment":120}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":5,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Rivastigmine prevention of delirium","genericName":"Rivastigmine prevention of delirium","companyName":"University Hospital, Basel, Switzerland","companyId":"university-hospital-basel-switzerland","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Rivastigmine is a cholinesterase inhibitor that works by increasing the concentration of acetylcholine in the brain, which helps to improve cognitive function and prevent delirium. Used for Prevention of delirium.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}