{"id":"rituximab-injection-truxima","brandName":"RiTUXimab Injection [Truxima]","genericName":"RiTUXimab Injection [Truxima]","companyId":"laida-cuevas-palomares","companyName":"Laida Cuevas Palomares","phase":"marketed","status":"active","modality":"Small molecule","aliases":[],"developmentCodes":[],"firstApprovalDate":null,"firstApprovalCountry":null,"aiSummary":"Rituximab Injection (Truxima) is a biosimilar monoclonal antibody targeting CD20-positive B cells, used primarily in the treatment of non-Hodgkin's lymphoma and chronic lymphocytic leukemia. It has no FDA label or clinical trials listed, indicating limited regulatory approval and research activity.","enrichmentLevel":3,"visitCount":0,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Rituximab targets the CD20 antigen expressed on the surface of B lymphocytes. Upon binding, it triggers multiple mechanisms of B cell destruction including antibody-dependent cellular cytotoxicity (ADCC), complement-dependent cytotoxicity (CDC), and direct induction of apoptosis. This results in rapid depletion of B cells, reducing autoimmune and malignant B cell populations.","oneSentence":"Rituximab is a chimeric monoclonal antibody that binds to CD20 on B cells, leading to their depletion through antibody-dependent cellular cytotoxicity and direct apoptosis.","_ai_confidence":"high"},"administration":{},"safety":{"commonSideEffects":[{"rate":"30-50","effect":"Infusion reactions"},{"rate":"10-20","effect":"Fever"},{"rate":"10-20","effect":"Chills"},{"rate":"15-25","effect":"Infections"},{"rate":"5-15","effect":"Neutropenia"},{"rate":"5-10","effect":"Anemia"},{"rate":"5-10","effect":"Thrombocytopenia"},{"rate":"10-15","effect":"Fatigue"}]},"trials":[],"indications":{"approved":[{"name":"Non-Hodgkin's lymphoma (B-cell)"},{"name":"Chronic lymphocytic leukemia (CLL)"},{"name":"Rheumatoid arthritis"},{"name":"Granulomatosis with polyangiitis (GPA)"},{"name":"Microscopic polyangiitis (MPA)"}]},"commercial":null,"patents":[],"timeline":[],"rwe":[],"competitors":[],"ownershipHistory":[],"trialDetails":[],"genericFilers":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"labelChanges":[],"nice":null,"revenue":null,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}