{"id":"ritodrine","rwe":[{"pmid":"41835753","year":"2026","title":"Unilateral Pulmonary Edema Associated With Prolonged Lateral Decubitus Positioning During Tocolytic Therapy in Pregnancy: A Case Report.","finding":"","journal":"Cureus","studyType":"Clinical Study"},{"pmid":"41794314","year":"2026","title":"Comparative effectiveness of intravenous remifentanil, epidural anesthesia and a two-step analgesic approach for external cephalic version: a large prospective single-center cohort study.","finding":"","journal":"American journal of obstetrics and gynecology","studyType":"Clinical Study"},{"pmid":"41725325","year":"2026","title":"Practical technique and clinical management guide for external cephalic version.","finding":"","journal":"Obstetrics & gynecology science","studyType":"Clinical Study"},{"pmid":"41720891","year":"2026","title":"Association between betamimetics tocolysis duration and maternal adverse events: a national real-world data analysis from Japan.","finding":"","journal":"Scientific reports","studyType":"Clinical Study"},{"pmid":"41695005","year":"2026","title":"Two Cases of Catheter-Related Bloodstream Infection: A Previously Unreported Complication of Long-Term Ritodrine Tocolysis.","finding":"","journal":"Cureus","studyType":"Clinical Study"}],"tags":[{"label":"ritodrine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Beta-2 adrenergic receptor","category":"target"},{"label":"ADRB2","category":"gene"},{"label":"ADRB3","category":"gene"},{"label":"G02CA01","category":"atc"},{"label":"Off-Patent","category":"patent"},{"label":"Generic Available","category":"availability"},{"label":"Mature","category":"status"},{"label":"Premature labor","category":"indication"},{"label":"Hospira","category":"company"},{"label":"Approved 1990s","category":"decade"},{"label":"Adrenergic Agents","category":"pharmacology"},{"label":"Adrenergic Agonists","category":"pharmacology"},{"label":"Adrenergic beta-2 Receptor Agonists","category":"pharmacology"},{"label":"Adrenergic beta-Agonists","category":"pharmacology"},{"label":"Neurotransmitter Agents","category":"pharmacology"},{"label":"Peripheral Nervous System Agents","category":"pharmacology"},{"label":"Reproductive Control Agents","category":"pharmacology"},{"label":"Sympathomimetics","category":"pharmacology"},{"label":"Tocolytic Agents","category":"pharmacology"}],"phase":"marketed","safety":{"safetySignals":[{"llr":331.321,"date":"","count":84,"signal":"Premature baby","source":"DrugCentral FAERS","actionTaken":"Reported 84 times (LLR=331)"},{"llr":313.198,"date":"","count":66,"signal":"Low birth weight baby","source":"DrugCentral FAERS","actionTaken":"Reported 66 times (LLR=313)"},{"llr":253.444,"date":"","count":87,"signal":"Exposure during pregnancy","source":"DrugCentral FAERS","actionTaken":"Reported 87 times (LLR=253)"},{"llr":252.185,"date":"","count":78,"signal":"Foetal exposure during pregnancy","source":"DrugCentral 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It is used to treat premature labor and was FDA approved in 1991. As an off-patent medication, it is available as a generic from multiple manufacturers. Key safety considerations include its short half-life of 2.6 hours and moderate bioavailability of 30%. Lavopa's commercial status allows for generic competition.","approvals":[{"date":"1991-01-22","orphan":false,"company":"HOSPIRA","regulator":"FDA"}],"brandName":"Lavopa","ecosystem":[{"indication":"Premature labor","otherDrugs":[],"globalPrevalence":null}],"mechanism":{"target":"Beta-2 adrenergic receptor","novelty":"Follow-on","targets":[{"gene":"ADRB2","source":"DrugCentral","target":"Beta-2 adrenergic receptor","protein":"Beta-2 adrenergic receptor"},{"gene":"ADRB3","source":"DrugCentral","target":"Beta-3 adrenergic receptor","protein":"Beta-3 adrenergic receptor"}],"modality":"Small Molecule","drugClass":"ritodrine","explanation":"","oneSentence":"","technicalDetail":"Ritodrine is a beta-2 adrenergic agonist that stimulates the beta-2 receptor, leading to increased levels of cyclic AMP (cAMP) and subsequent relaxation of uterine smooth muscle."},"commercial":{"launchDate":"1991","_launchSource":"DrugCentral (FDA 1991-01-22, HOSPIRA)"},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/2390","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=RITODRINE","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=RITODRINE","fields":["publications"],"source":"PubMed/NCBI"},{"id":4,"url":"https://www.fda.gov/drugs/drug-approvals-and-databases/orange-book-data-files","fields":["patents","exclusivity","genericManufacturers"],"source":"FDA Orange Book"}],"_enrichedAt":"2026-03-30T15:35:55.803648","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T03:15:40.448720+00:00","fieldsConflicting":2,"overallConfidence":0.8},"biosimilars":[],"competitors":[{"drugName":"acebutolol","drugSlug":"acebutolol","fdaApproval":"1984-12-28","genericCount":3,"patentStatus":"Off-patent — generic 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