{"id":"risperidone-and-zotepine-for-delirium","safety":{"commonSideEffects":[{"rate":null,"effect":"Extrapyramidal symptoms (tremor, rigidity, akathisia)"},{"rate":null,"effect":"Sedation"},{"rate":null,"effect":"Orthostatic hypotension"},{"rate":null,"effect":"Weight gain"},{"rate":null,"effect":"Metabolic syndrome risk"},{"rate":null,"effect":"QT prolongation"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Both agents are second-generation antipsychotics that antagonize dopamine D2 receptors in the mesolimbic and mesocortical pathways, reducing psychotic symptoms and agitation. Zotepine additionally has potent 5-HT2A antagonism and noradrenergic activity, while risperidone's serotonergic blockade contributes to mood stabilization. This combination approach targets multiple neurotransmitter systems implicated in delirium pathophysiology.","oneSentence":"Risperidone and zotepine are atypical antipsychotics that block dopamine D2 and serotonin 5-HT2A receptors to reduce agitation, hallucinations, and delirium symptoms.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:05:23.333Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Delirium (acute confusion and agitation in hospitalized patients)"}]},"trialDetails":[{"nctId":"NCT00622011","phase":"PHASE4","title":"Risperidone and Zotepine in the Treatment of Delirium","status":"TERMINATED","sponsor":"Changhua Christian Hospital","startDate":"2008-01","conditions":"Delirium","enrollment":5}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["risperidone( Risperdal), zotepine( Lodopine)"],"phase":"marketed","status":"active","brandName":"Risperidone and Zotepine for delirium","genericName":"Risperidone and Zotepine for delirium","companyName":"Changhua Christian Hospital","companyId":"changhua-christian-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Risperidone and zotepine are atypical antipsychotics that block dopamine D2 and serotonin 5-HT2A receptors to reduce agitation, hallucinations, and delirium symptoms. Used for Delirium (acute confusion and agitation in hospitalized patients).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}