{"id":"risperidone-and-ramelteon","safety":{"commonSideEffects":[{"rate":null,"effect":"Extrapyramidal symptoms (tremor, rigidity)"},{"rate":null,"effect":"Sedation"},{"rate":null,"effect":"Weight gain"},{"rate":null,"effect":"Prolactin elevation"},{"rate":null,"effect":"Headache"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Risperidone blocks dopamine D2 and serotonin 5-HT2A receptors, reducing psychotic symptoms and agitation in schizophrenia and bipolar disorder. Ramelteon selectively agonizes melatonin MT1 and MT2 receptors to regulate circadian rhythm and promote sleep, addressing the common comorbid insomnia in psychiatric patients.","oneSentence":"This combination uses risperidone (a dopamine antagonist) to manage psychotic symptoms and ramelteon (a melatonin receptor agonist) to improve sleep disturbances.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:05:16.852Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Schizophrenia with comorbid insomnia"},{"name":"Bipolar disorder with sleep disturbance"}]},"trialDetails":[{"nctId":"NCT03075657","phase":"PHASE4","title":"Study of add-on Ramelteon Therapy on Sleep and Circadian Rhythm Disruption in Patients With Schizophrenia","status":"COMPLETED","sponsor":"All India Institute of Medical Sciences, Bhubaneswar","startDate":"2017-05-01","conditions":"Schizophrenia","enrollment":120}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":8,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Risperidone and Ramelteon","genericName":"Risperidone and Ramelteon","companyName":"All India Institute of Medical Sciences, Bhubaneswar","companyId":"all-india-institute-of-medical-sciences-bhubaneswar","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination uses risperidone (a dopamine antagonist) to manage psychotic symptoms and ramelteon (a melatonin receptor agonist) to improve sleep disturbances. Used for Schizophrenia with comorbid insomnia, Bipolar disorder with sleep disturbance.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}